Health Benefits and Pharmacological Properties of Carvone

Abstract

Carvone is a monoterpene ketone contained in the essential oils of several aromatic and medicinal plants of the Lamiaceae and Asteraceae families. From aromatic plants, this monoterpene is secreted at different concentrations depending on the species, the parts used, and the extraction methods. Currently, pharmacological investigations showed that carvone exhibits multiple pharmacological properties such as antibacterial, antifungal, antiparasitic, antineuraminidase, antioxidant, anti-inflammatory, and anticancer activities. These studies were carried out in vitro and in vivo and involved a great deal of knowledge on the mechanisms of action. Indeed, the antimicrobial effects are related to the action of carvone on the cell membrane and to ultrastructural changes, while the anti-inflammatory, antidiabetic, and anticancer effects involve the action on cellular and molecular targets such as inducing of apoptosis, autophagy, and senescence. With its multiple mechanisms, carvone can be considered as natural compounds to develop therapeutic drugs. However, other investigations regarding its precise mechanisms of action as well as its acute and chronic toxicities are needed to validate its applications. Therefore, this review discusses the principal studies investigating the pharmacological properties of carvone, and the mechanism of action underlying some of these properties. Moreover, further investigations of major pharmacodynamic and pharmacokinetic studies were also suggested.

<em>In-vitro</em> Study of Chemical Composition, Antimicrobial and Antioxidant Properties of <em>Adiantum capillus-veneris</em> L. Essential Oil

“…The CAS number of this article is 5-75-8006. Based on a pre-clinical experimental study, this substance has a statistically significant sedative effect against increased excitement [13,31,32]. Carvacrol is a monoterpene phenolic compound with a structure of 5-isopropyl -2-methyl phenol and a chemical formula of C10H14O [33].…”

Mechanisms, Anti-Quorum-Sensing Actions, and Clinical Trials of Medicinal Plant Bioactive Compounds against Bacteria: A Comprehensive Review

“…Therefore, researchers have been searching for alternatives to conventional antibiotics. Within this context, natural substances, particularly those extracted from medicinal plants, constitute a source of drugs against various pathologies, including diabetes, cancer, inflammation, and pathologies linked to stress and microbial infections [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. The antibacterial activity of these natural products is linked to different mechanisms of action, such as the increase in membrane permeability, the decrease in membrane integrity, and the disruption of efflux pumps [ 10 , 13 , 18 , 19 ].…”

Antioxidant, Antidiabetic, and Antibacterial Potentials and Chemical Composition of Salvia officinalis and Mentha suaveolens Grown Wild in Morocco

“…Despite this, only around 5%–15% of the roughly 250,000 higher plants have ever been studied for pharmacological activities [ 2 ]. Numerous studies conducted over the last few decades have shown that research on therapeutic plants is critical and bioactive phytochemicals or bionutrients are abundant in medicinal plants; these phytochemicals have a critical role in avoiding chronic illnesses such as cancer [ 3 – 5 ], diabetes [ 6 – 9 ], and coronary heart disease [ 10 – 12 ]. Dietary fiber, detoxifying agents, antioxidants, anticancer, neuropharmacological agents, and immune-stimulating agents are the key groups of phytochemicals having disease-preventive properties [ 13 ].…”