Ileum transcriptional response to prolonged supplementation with phytogenic product containing menthol, carvacrol and carvone

Bajagai, Yadav S.; Petranyi, Friedrich; Horyanto, Darwin; Batacan, Romeo; Lobo, Edina; Ren, Xipeng; Whitton, Maria M.; Yu, Sung J.; Kayal, Advait; Stanley, Dragana

doi:10.1016/j.heliyon.2022.e09131

Cited by 2 publications

(3 citation statements)

References 63 publications

(71 reference statements)

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“…The industry invested in alternative and natural antimicrobial products capable of controlling pathogens, such as biochar (Willson et al 2019), zeolite (Prasai et al 2017) or plant-derived complex phytogenic products (Bajagai et al 2020;Flees et al 2021;Greene et al 2021;Wang et al 2021). Recently, using a mixed phytogenic alternative product, RNAseq analysis showed that herb-based antibiotic alternative triggers ileum gene expression response significantly matching the response to doxycycline and geldanamycin (Bajagai et al 2022), indicating a broad spectrum of the antibiotic alternative products. The main products of the livestock industry, such as meat, milk or eggs, are meant for human consumption; however, byproducts such as manure play a significant role in other areas of agriculture.…”

Section: Amr From the Agriculturementioning

confidence: 99%

Rapid growth of antimicrobial resistance: the role of agriculture in the problem and the solutions

Stanley

Batacan

Bajagai

2022

Appl Microbiol Biotechnol

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The control of infectious diseases has always been a top medical priority. For years during the so-called antibiotic era, we enjoyed prolonged life expectancy and the benefits of superior pathogen control. The devastating failure of the medical system, agriculture and pharmaceutical companies and the general population to appreciate and safeguard these benefits is now leading us into a grim post-antibiotic era. Antimicrobial resistance (AMR) refers to microorganisms becoming resistant to antibiotics that were designed and expected to kill them. Prior to the COVID-19 pandemic, AMR was recognised by the World Health Organization as the central priority area with growing public awareness of the threat AMR now presents. The Review on Antimicrobial Resistance, a project commissioned by the UK government, predicted that the death toll of AMR could be one person every 3 seconds, amounting to 10 million deaths per year by 2050. This review aims to raise awareness of the evergrowing extensiveness of antimicrobial resistance and identify major sources of this adversity, focusing on agriculture’s role in this problem and its solutions. Keypoints • Widespread development of antibiotic resistance is a major global health risk. • Antibiotic resistance is abundant in agricultural produce, soil, food, water, air and probiotics. • New approaches are being developed to control and reduce antimicrobial resistance.

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Section: Amr From the Agriculturementioning

confidence: 99%

Rapid growth of antimicrobial resistance: the role of agriculture in the problem and the solutions

Stanley

Batacan

Bajagai

2022

Appl Microbiol Biotechnol

Self Cite

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“…Studies investigating transcriptomic effects of the PFA supplementation in birds reported elevated expression of antioxidant genes [ 13 ], increased endocytosis and autophagy [ 14 ], inhibition of steroid hormones [ 15 ], and an increase in fat and carbohydrate metabolism-related pathways [ 16 ]. The outcomes of these studies indicated a high level of PFA interference with disease and metabolism-related pathways and interference with the efficiency of numerous medical drugs and supplements [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…To our knowledge, this is the first ileum gene expression study based on this phytogenic blend in layer birds. A similar ileum transcriptomic study on the effects of different blends of phytogens has reported an increase in the range of beneficial roles such as vasculogenesis, homeostasis, engulfment of tumour cells, the function of muscle, autophagy, obesity, gut health immune system and much more [ 14 ]. Industry-based trials have less control over environmental and biosecurity conditions and usually come with a very high number of birds per shed, up to 100,000 birds, which causes issues with sample size.…”

Section: Introductionmentioning

confidence: 99%

Phytogenic Blend Improves Intestinal Health and Reduces Obesity, Diabetes, Cholesterol and Cancers: A Path toward Customised Supplementation

Bajagai

Petranyi

et al. 2022

Antibiotics

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Poultry production is among the most challenging industries for pathogen control. High animal density and abundance of faecal material demand strict biosecurity measures and continual vigilance in monitoring animal health parameters. Despite this vigilance, dealing with disease outbreaks is a part of farmers’ routines. Phytogenic feed additives comprised of herbs, spices, essential oils, and oleoresins have potent antimicrobial and anti-inflammatory actions. Related studies are gaining substantial interest in human and animal health worldwide. In this study, a commercial blend phytogenic feed additive was supplemented to layers in an industrial free-range production system with 20,000 birds in both control and treatment groups. At the end of the trial, the ileum tissue was sampled for RNAseq transcriptomic analysis to study the host reaction to the supplement. Phytogenic supplement significantly inhibited four cholesterol-related pathways and reduced the Arteriosclerosis disease category towards improved cardiovascular health. The supplemented birds exhibited reduced disease susceptibility for 26 cancer categories with p-values in the range from 5.23 × 10−4 to 1.02 × 10−25. Major metabolic shifts in Lipid metabolism in combination with Carbohydrate metabolism have resulted in a decrease in the Obesity category, altering the ratio of fat and carbohydrate metabolism toward lower fat storage.

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Ileum transcriptional response to prolonged supplementation with phytogenic product containing menthol, carvacrol and carvone

Cited by 2 publications

References 63 publications

Rapid growth of antimicrobial resistance: the role of agriculture in the problem and the solutions

Rapid growth of antimicrobial resistance: the role of agriculture in the problem and the solutions

Phytogenic Blend Improves Intestinal Health and Reduces Obesity, Diabetes, Cholesterol and Cancers: A Path toward Customised Supplementation

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