Anti-Apoptotic Mechanisms of Acupuncture in Neurological Diseases: A Review

Cai, Wa; Wei-dong, SU

doi:10.1142/s0192415x1850026x

Cited by 37 publications

(22 citation statements)

References 90 publications

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“…From the historical perspective, Baihui is the most often-chosen principle acupoint in treating neurological diseases like ischemic stroke and dementia. Nowadays, various basic studies have also confirmed that scalp acupuncture at Baihui plays multiple neuroprotective roles including antiapoptosis, anti-inflammatory, and perfusion augmentation in the pathophysiological process of laboratory models of ischemic stroke, not only regulating oxidative stress [ 24 , 100 – 102 ]. It has also been reported that acupuncture at Dazhui could enhance the activity of SOD and GSH-Px [ 78 , 92 ], improve perfusion in the ischemic zone, and promote the proliferation of neuronal stem cells [ 101 , 103 ].…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of Acupuncture in the Regulation of Oxidative Stress in Treating Ischemic Stroke

Wang

et al. 2020

Oxidative Medicine and Cellular Longevity

111

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Ischemic stroke is the major type of cerebrovascular disease usually resulting in death or disability among the aging population globally. Oxidative stress has been closely linked with ischemic stroke. Disequilibrium between excessive production of reactive oxygen species (ROS) and inherent antioxidant capacity leads to subsequent oxidative damage in the pathological progression of ischemic brain injury. Acupuncture has been applied widely in treating cerebrovascular diseases from time immemorial in China. This review mainly lays stress on the evidence to illuminate the possible mechanisms of acupuncture therapy in treating ischemic stroke through regulating oxidative stress. We found that by regulating a battery of molecular signaling pathways involved in redox modulation, acupuncture not only activates the inherent antioxidant enzyme system but also inhibits the excessive generation of ROS. Acupuncture therapy possesses the potential in alleviating oxidative stress caused by cerebral ischemia, which may be linked with the neuroprotective effect of acupuncture.

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Section: Discussionmentioning

confidence: 99%

Mechanisms of Acupuncture in the Regulation of Oxidative Stress in Treating Ischemic Stroke

Wang

et al. 2020

Oxidative Medicine and Cellular Longevity

111

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“…It is known that Bcl-2 is a tumor suppressor gene which significantly inhibits apoptosis, while Bax is an apoptotic gene which inhibits Bcl-2. It has been reported that the Bcl-2/Bax ratio is a key factor that determines the degree of apoptosis [18]. The results of this study showed that morphine pretreatment significantly raised mRNA levels of p-p38, p-GSK-3β, p-Cx43, Bcl-2 and Bcl-2/Bax, while Bax mRNA levels were decreased.…”

Section: Studiesmentioning

confidence: 46%

Morphine pretreatment reduces myocardial ischemiareperfusion injury in heart failure rats via GSK-3β/Cx43 signaling proteins and apoptosis-related gene, Bcl-2/Bax

Zhu¹,

Geng²,

Han³

et al. 2020

Trop. J. Pharm Res

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Purpose: To investigate the effect of morphine preconditioning on myocardial ischemia reperfusion injury in heart failure rats, and the mechanism(s) of action involvedMethods: Seventy-two healthy male Sprague-Dawley rats were assigned to 4 groups: sham, model, morphine-preconditioning and SB203580 inhibitor groups, each with 18 rats. The expressions of P-p38, p-glycogen synthetase kinase-3, and p-gap junction protein 43 in rat myocardial cells were assayed by Western blotting. The mRNA expression levels of Bcl-2 and Bax, and Bcl-2/Bax were determined using real-time fluorescence quantitative PCR.Results: The expression levels of P-p38, p-glycogen synthetase kinase-3, p-gap junction protein 43, Bcl-2 mRNA and Bcl-2/Bax were significantly higher in the pretreatment group than in the model group, while Bax mRNA was significantly lower (p < 0.05). Moreover, the mRNA expression levels of P-p38, pglycogen synthetase kinase-3, p-gap junction protein, Bcl-2, and Bcl-2/Bax in inhibitor-treated rats decreased significantly, when compared to the values for pretreatment rats; furthermore, Bax mRNA was markedly upregulated (p < 0.05).Conclusion: Morphine preconditioning significantly inhibits the expressions of GSK-3β and Cx43 signaling proteins, as well as apoptosis-related gene, Bcl-2 and Bax. In addition, it inhibits the apoptosis of rat cardiomyocytes, and reduces myocardial injury, after ischemia reperfusion, via activation of the p38 MARK signaling pathway. This provides a new strategy for clinical reduction of myocardial injury after ischemia-reperfusion. Keywords: Morphine, Pretreatment, GSK-3β/Cx43 signaling protein, Bcl-2/Bax, Heart failure, Ischemiareperfusion injury

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“…Later, acupuncture was introduced to other regions, including Asia, Europe, and the United States [ 54 ]. It was proven to be effective for a variety of neurological diseases, including PD [ 6 , 24 ]. PD is a chronic neurodegenerative disease characterized by selective loss of dopaminergic neurons in the substantia nigra, resulting in abnormal motor behavior.…”

Section: Discussionmentioning

confidence: 99%

Electroacupuncture alleviates Parkinson disease and regulates the expression of brain-gut peptides

Min

et al. 2020

Exp. Anim.

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The non-motor symptoms (NMS) of Parkinson’s disease (PD) are found in more than 90% of patients with PD. Here, we explored the effects of electroacupuncture (EA) stimulation at Zhong wan (CV-12), Qihai (RN-7), Zusanli (ST-36) and Taichong (LR-3) on NMS and brain-gut peptides of PD. We found that EA intervention alleviated the motor deficit induced by 6-OHDA in rats indicated by the decreased abnormal involuntary movements (AIMs) scores and the net number of rotations and increased cylinder test grade. It also improved the spatial memory and attenuated anxiety-like and depression of PD model rats. EA treatment significantly inhibited neuronal apoptosis in PD model animals, as demonstrated by the increased number of TH positive cells and reduced number of apoptotic cells in the substantia nigra. The expression of cleaved caspase-3 and cleaved PARP in PD model rats was markedly suppressed by EA stimulation. Moreover, EA remarkably inhibited the inflammatory response in PD model rats, as revealed by the decreased levels of TNF-α, IL-1β, and COX-2 mRNA expression. It also attenuated the oxidative stress in rats, as indicated by the increased levels of SOD and GSH and the decreased level of MDA. EA treatment contributed to alleviating PD by regulating brain-gut peptides in rats, such as NPY, CCK, SST, GAS, and PYY. In conclusion, EA stimulation at CV-12, RN-7, ST-36, and LR-3 effectively alleviates the NMS of PD partly through regulating the levels of brain-gut peptides.

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Anti-Apoptotic Mechanisms of Acupuncture in Neurological Diseases: A Review

Cited by 37 publications

References 90 publications

Mechanisms of Acupuncture in the Regulation of Oxidative Stress in Treating Ischemic Stroke

Mechanisms of Acupuncture in the Regulation of Oxidative Stress in Treating Ischemic Stroke

Morphine pretreatment reduces myocardial ischemiareperfusion injury in heart failure rats via GSK-3β/Cx43 signaling proteins and apoptosis-related gene, Bcl-2/Bax

Electroacupuncture alleviates Parkinson disease and regulates the expression of brain-gut peptides

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