Mechanisms of Acupuncture in the Regulation of Oxidative Stress in Treating Ischemic Stroke

Su, Xin-Tong; Wang, Lu; Ma, Si‐Ming; Cao, Yan; Yang, Nana; Lin, Lu-Lu; Fisher, Marc; Yang, Jing‐Wen; Liu, Cun‐Zhi

doi:10.1155/2020/7875396

Cited by 113 publications

(81 citation statements)

References 103 publications

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“…Indeed, the use of antioxidants in animals has been successful in treating stroke [ 398 ]; furthermore, several clinical trials show that co-antioxidants exert protections in stroke, including flavonoid and melatonin [ 399 , 400 ]. Moreover, clinical trials show that also acupuncture stimulates the inherent antioxidant enzyme system and inhibits the disproportionate generation of ROS, by regulating a series of molecular signaling pathways in redox modulation [ 401 ]. Acupuncture therapy has the potential in alleviating oxidative stress caused by cerebral ischemia, which may be associated with the neuroprotective effect of acupuncture [ 401 ].…”

Section: Aging Oxidative Stress and Vascular Diseasesmentioning

confidence: 99%

“…Moreover, clinical trials show that also acupuncture stimulates the inherent antioxidant enzyme system and inhibits the disproportionate generation of ROS, by regulating a series of molecular signaling pathways in redox modulation [ 401 ]. Acupuncture therapy has the potential in alleviating oxidative stress caused by cerebral ischemia, which may be associated with the neuroprotective effect of acupuncture [ 401 ]. In conclusion, reducing stroke frequency by preventive measures, as well as cerebrovascular dementia, is essential to avoid the natural trend of increase in the human, economic and social burden of these diseases.…”

Section: Aging Oxidative Stress and Vascular Diseasesmentioning

confidence: 99%

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The Role of Oxidative Stress in Cardiovascular Aging and Cardiovascular Diseases

Izzo

Vitillo

Pietro

et al. 2021

Life

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Aging can be seen as process characterized by accumulation of oxidative stress induced damage. Oxidative stress derives from different endogenous and exogenous processes, all of which ultimately lead to progressive loss in tissue and organ structure and functions. The oxidative stress theory of aging expresses itself in age-related diseases. Aging is in fact a primary risk factor for many diseases and in particular for cardiovascular diseases and its derived morbidity and mortality. Here we highlight the role of oxidative stress in age-related cardiovascular aging and diseases. We take into consideration the molecular mechanisms, the structural and functional alterations, and the diseases accompanied to the cardiovascular aging process.

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Section: Aging Oxidative Stress and Vascular Diseasesmentioning

confidence: 99%

Section: Aging Oxidative Stress and Vascular Diseasesmentioning

confidence: 99%

The Role of Oxidative Stress in Cardiovascular Aging and Cardiovascular Diseases

Izzo

Vitillo

Pietro

et al. 2021

Life

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“…The frequently applied local points were Bai-hui (GV20), Si-shen-cong (EX-HN1), Shen-ting (GV24), Feng-chi (GB20), Shui-gou (GV26), and Ben-shen (GB13), whereas the frequently chosen distant points were Nei-guan (PC6), Zu-san-li (ST36), San-yin-jiao (SP6), and Tai-xi (KI3). According to the meridian system of acupuncture based on TCM, the GV Meridian plays an essential role in modulating cerebral function including cognition (Su et al, 2020b). The primary acupoints selected are those who belong to DV Meridian and distribute on the craniofacial region, whereas the auxiliary acupoints are those essential acupoints that can lift spirit, clear mind, or promote resuscitation and distribute on the limbs.…”

Section: Applicability For Clinical Practicementioning

confidence: 99%

Effectiveness and Safety of Acupuncture for Vascular Cognitive Impairment: A Systematic Review and Meta-Analysis

Sun

Zhang

et al. 2021

Front. Aging Neurosci.

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Background: Acupuncture may be a promising complementary therapy for vascular cognitive impairment (VCI) and has been extensively applied in China. However, its potential effects remain uncertain, and the clinical findings are inconsistent. This review aimed to systematically appraise the overall effectiveness and safety of acupuncture in treating VCI.Methods: To investigate the effects of acupuncture on VCI from inception to February 28, 2021 using randomized clinical trials (RCTs), seven electro-databases [Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Embase, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), VIP, and Wanfang] were searched. Two independent investigators identified the eligible RCTs and extracted data into predesigned forms. The risk of bias (ROB) within each individual trial was evaluated using the Cochrane Collaboration's tool. Meta-analyses were conducted for calculating comparative effects in the RevMan software (version 5.3). The strength of attained evidence was rated using the online GRADEpro approach.Results: A total of 48 RCTs involving 3,778 patients with VCI were included. The pooled data demonstrated that acupuncture was more beneficial for a global cognitive function [mean difference (MD) 1.86, 95% CI 1.19–2.54, p < 0.01] and activities of daily living (MD −3.08, 95% CI −4.81 to −1.35, p < 0.01) compared with western medicine (WM). The favorable results were also observed when acupuncture was combined with WM (MD 2.37, 95% CI 1.6–3.14, p < 0.01) or usual care (UC, MD 4.4, 95% CI 1.61–7.19, p = 0.002) in comparison with the corresponding control conditions. Meanwhile, the subgroup analysis did not indicate a statistical effect difference between manual acupuncture (MA) and electroacupuncture (EA) (inter-group I2 < 50% and p > 0.1) when comparing acupuncture with WM. There were no significant differences in the occurrence of adverse events (AEs) between the acupuncture group and the control group (p > 0.05). Owing to the poor methodological quality and considerable heterogeneity among studies, the certainty of the evidence was low or very low.Conclusions: This review suggests that acupuncture as a monotherapy or an adjuvant therapy may play a positive role in improving the cognition and daily performance of VCI patients associated with few side effects. The difference in styles may not significantly influence its effectiveness. More rigorously designed and preregistered RCTs are highly desirable to verify the therapeutic benefits and determine an optimal acupuncture paradigm. The methodological and reporting quality of future researches should be enhanced by adhering to authoritative standardized statements.Systematic Review Registration: [PROSPERO], identifier [No. CRD42017071820].

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“…These events result in the interruption of blood flow and consequently the death of the cerebral tissues. Several risk factors are known to increase the risk for IS, such as age, gender, hypertension, diabetes mellitus, hypercholesterolemia, excessive alcohol consumption, cigarette smoking, or other stressors [2, [6][7][8]. IS not only alters the homeostasis of the nervous system, but also affects other tissues and organs following the genesis of atherosclerotic and inflammatory processes causing heart failure [4].…”

Section: Introductionmentioning

confidence: 99%

MiRNA: Involvement of the MAPK Pathway in Ischemic Stroke. A Promising Therapeutic Target

et al. 2021

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Ischemic stroke (IS) is a cerebrovascular disease with a high rate of disability and mortality. It is classified as the second leading cause of death that arises from the sudden occlusion of small vessels in the brain with consequent lack of oxygen and nutrients in the brain tissue. Following an acute ischemic event, the cascade of events promotes the activation of multiple signaling pathways responsible for irreversible neuronal damage. The mitogen-activated protein kinase (MAPK) signaling pathway transmits signals from the cell membrane to the nucleus in response to different stimuli, regulating proliferation, differentiation, inflammation, and apoptosis. Several lines of evidence showed that MAPK is an important regulator of ischemic and hemorrhagic cerebral vascular disease; indeed, it can impair blood–brain barrier (BBB) integrity and exacerbate neuroinflammation through the release of pro-inflammatory mediators implementing neurovascular damage after ischemic stroke. This review aims to illustrate the miRNAs involved in the regulation of MAPK in IS, in order to highlight possible targets for potential neuroprotective treatments. We also discuss some miRNAs (miR), including miR-145, miR-137, miR-493, and miR-126, that are important as they modulate processes such as apoptosis, neuroinflammation, neurogenesis, and angiogenesis through the regulation of the MAPK pathway in cerebral IS. To date, limited drug therapies are available for the treatment of IS; therefore, it is necessary to implement preclinical and clinical studies aimed at discovering novel therapeutic approaches to minimize post-stroke neurological damage.

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Mechanisms of Acupuncture in the Regulation of Oxidative Stress in Treating Ischemic Stroke

Cited by 113 publications

References 103 publications

The Role of Oxidative Stress in Cardiovascular Aging and Cardiovascular Diseases

The Role of Oxidative Stress in Cardiovascular Aging and Cardiovascular Diseases

Effectiveness and Safety of Acupuncture for Vascular Cognitive Impairment: A Systematic Review and Meta-Analysis

MiRNA: Involvement of the MAPK Pathway in Ischemic Stroke. A Promising Therapeutic Target

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