Anti-anxiety studies on extracts of Passiflora incarnata Linneaus

Dhawan, Kamaldeep; Kumar, Suresh; Sharma, Anupam

doi:10.1016/s0378-8741(01)00339-7

Cited by 150 publications

(120 citation statements)

References 13 publications

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“…This data is supported by the earlier work of Dhawan et al (2001), eliminating chrysin, apigenin, quercetin, hesperidin and orientin as candidate mediators of this effect by adopting a progressive fractionation of Passiflora incarnata to isolate a fraction found to elicit the greatest anxiolytic activity using an elevated plus-maze model of anxiety in Swiss mice. The final fraction contained -sitosterol and a single unidentified flavone (Dhawan et al, 2001) which may therefore be either vicenin-2 or spinosin.…”

Section: II Anti-inflammatory Activitysupporting

confidence: 71%

The Occurrence, Fate and Biological Activities ofC-glycosyl Flavonoids in the Human Diet

Courts

Williamson

2013

Critical Reviews in Food Science and Nutrition

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Section: II Anti-inflammatory Activitysupporting

confidence: 71%

The Occurrence, Fate and Biological Activities ofC-glycosyl Flavonoids in the Human Diet

Courts

Williamson

2013

Critical Reviews in Food Science and Nutrition

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“…Anxiety is one of the most common mental disorders affecting mankind. Its prevalence is increasing in recent years due to the rather tense "man's zest to win nature" (Dhawan et al, 2001); that is, the rather tense lifestyle imposed on man by the competitive and inhumane atmosphere pervading everyday life. Anxiolytic substances, mostly belonging to the benzodiazepine group, occupy a prominent position in the ranking of the drugs most utilized drugs by man (Uhlenhuth et al, 1999) to minimize stress, tension, and anxiety (Argyropoulos & Nutt, 1999).…”

Section: Discussionmentioning

confidence: 99%

Anxiolytic Properties ofMyrica nagiBark Extract

Khan¹,

sagrawat²,

Upmanyu³

et al. 2008

Pharmaceutical Biology

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Myrica nagi Hook (syn. Myrica esculenta Buch. & Ham) (Myricaceae) is commonly known as box berry. The bark of Myrica nagi is used in the treatment of mental illness by different ethnic groups of the rural region of Orissa (India). In the present work, the anxiolytic and antidepressant effects of an ethanol extract of M. nagi were analyzed at three different dosages (100, 200, and 400 mg/kg, p.o.) by elevated plus-maze, light/dark exploration test, tail suspension test, and the forced swimming model. Oral administration of the ethanol extract (100, 200, and 400 mg/kg, p.o.) of M. nagi showed significant (p < 0.01) and dose-dependent anxiolytic activity by increasing time spent in the open arms of the elevated plus-maze and in the lit box indicating an anxiolytic effect. Nevertheless this treatment was unable to exhibit an effect identical to antidepressants in the tail suspension and forced swimming tests. Altogether, these results suggest an anxiolytic effect of the ethanol extract of M. nagi.

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“…The principal bioactive compounds described in this genus are C-glycosil flavonoids (vitexin, isovitexin, orientin, isoorientin and apigenin) and β-carbolinic alkaloids (harman, harmin, harmalin, harmol and harmalol) (Blumenthal et al, 2000). Some reports have pointed out the harman alkaloids (Alonso, 1998) as the bioactive constituents of Passiflora incarnata Linneu, one of the species of Passiflora that have been extensively studied chemically and biologically (Dhawan et al, 2001;Soulimani et al, 1997). Others indicate the flavonoid chrysin (Wolfman et al, 1994;Zanoli et al, 2000) or even maltol (Aoyagi et al, 1974) as the putative substances responsible for the tranquilizer activities.…”

Section: Introductionmentioning

confidence: 99%