Anxiolytic Properties of<i>Myrica nagi</i>Bark Extract

Khan, Yaseen; sagrawat, Hemant; Upmanyu, Neeraj; Siddique, Saiful Alom

doi:10.1080/13880200802315436

Cited by 23 publications

(17 citation statements)

References 29 publications

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“…Screening of ethanol extract of M. nagi bark at doses 300 and 500 mg/kg for neuro-pharmacological [83] , which contradicts the previous report that ethanol extract of M. nagi bark exhibited significantly and dose-dependent CNS-depressant effect as evident by increased duration of immobility in animals of extract treated groups as compare to control evaluated by tail immersion test and forced swimming test [37] .…”

Section: Antidepressant Activitycontrasting

confidence: 52%

“…has been reported to exhibit a dose-dependent significant anxiolytic activity as compare to standard drug diazepam evaluated by using two in vitro animal models such as elevated plus-maze and light/dark exploration test [37] .…”

Section: Anxiolytic Activitymentioning

confidence: 99%

“…Local people of Sub-Himalayan region use decoction of bark as mouth freshener and to cure toothache [35] while paste of bark is applied on wounds, joints pains and paralysis as well as used to cure cold and headache [36] . Bark is also used in the treatment of mental illness by different ethnic groups of the rural region of Orissa [37] . Fruit are eaten raw or used to prepare refreshing drinks while its juice is used against bacterial dysentery by tribal communities of Meghalaya [38][39][40] and bark is chewed to relieve toothache and for washing putrid sores [22,41] .…”

Section: Ethnobotanymentioning

confidence: 99%

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A Review on Ethnomedicinal, Phytochemical and Pharmacological Aspects of Myrica esculenta

Shri¹

2018

pharmaceutical-sciences

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Myrica esculenta (Myricaceae) commonly known as box berry or kaphal is an important Indian medicinal plant. It is found in foothill tracks of Eastern Himalayas, Meghalaya, Nepal, China and Pakistan. Local tribes mainly use its fruits to prepare pickle and refreshing drinks. Traditionally, the bark has been used for the treatment of cough, asthma, fever, chronic bronchitis, diarrhoea, rheumatism and inflammation; roots have been used in bronchitis, asthma, cholera and flowers claimed to treat earache, diarrhoea, paralysis. Phytochemical studies of the different parts of plant revealed the presence of various bioactive phytoconstituents such as phenolic compounds, alkaloids, glycosides, triterpenoids and volatile oils. The plant is also reported to have innumerable significant pharmacological activities like analgesic, anxiolytic, antiallergic, antidiabetic, antimicrobial, antihypertensive, antiulcer, antioxidant and antiinflammatory evaluated by using various animal models. The objective of the present review article is to compile all the relevant published information regarding traditional uses, phytochemistry and therapeutic potential of M. esculenta. For this purpose various databases and books were examined. The review clearly demonstrates the importance of this plant in ethnomedicine and its immense potential in modern medicine.

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Section: Antidepressant Activitycontrasting

confidence: 52%

Section: Anxiolytic Activitymentioning

confidence: 99%

Section: Ethnobotanymentioning

confidence: 99%

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A Review on Ethnomedicinal, Phytochemical and Pharmacological Aspects of Myrica esculenta

Shri¹

2018

pharmaceutical-sciences

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“…These include Qaranfal (Syzygium aromaticum) [30], Ood (Aquilaria agalocha), Sandal (Santalum album) [31], Anisoon (Pimpinella anisum) [2], Kaiphal (Myrica nagi) [32], Badiyan (Foeniculum vulgare) [33], Bahmen (Centaurea behen) [34], Bazarulbanj (Hyoscyamus niger) [35], Habb-ul-Ghar (Laurus Nobilis) [36], Halela (Terminalia chebula) [37], Ustokhuddoos (Lavendula steochas) [38], Kalaunji (Nigella sativa) [39], Sibr (Aloe barbadensis) [40] etc.…”

Section: Saad Kufi (Cyperous Rotundus Family -Cyperaceae)mentioning

confidence: 99%

The Role of Mufarrehat (Exhilarants) in the Management of Depression: An Evidence Based Approach

Anwar¹,

Ahmed²,

Kabiruddin³

et al. 2017

J Psychiatry

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“…6 The bark Possess anti-inflammatory 7 anti-helmintic 8 anti-microbial, 9,10 anxiolytic, 11 while the fruits are known for their anti-oxidant properties and Antimicrobial nature 12,13 The whole plant is an effective chemo preventive agent in skin.…”

Section: Introductionmentioning

confidence: 99%

Pharmacognostic Evaluation and Determination of Secondary Plant Metabolites by HPTLC and its Antioxidant Activity in Myrica esculenta

Kumar¹,

Gupta²,

Singh³

2017

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Introduction:Myrica esculenta Buch.-Ham. (Myricaceae) is commonly known as Box Berry, Kaiphal, and Katphala in Ayurveda. As per the Ayurvedic literature the palnt is used for variety of diseases and disorders. Method: The present study deals with the pharmacognostical standardization, HPTLC analysis and antioxidant activity of methanolict extracts of the leaves of M. esculenta. The plant showed high phenolic and flavonoid content. In-vitro antioxidant study of dried leaves of Myrica esculanta was performed using methanolic extract. Results: Antioxidant activity of M. esculenta methanolic extract showed the least IC 50 value of 60 ± 1.15 μg/ml. Standard ascorbic acid showed an IC 50 value of 2.03 ± 0.06 μg/ml. The calibration curve of Gallic acid showed r 2 of 0.949 and R f of gallic acid was found to be 0.44 ± 0.006. Quantification of gallic acid in the samples of leaves of M. esculenta has been performed and the gallic acid was found to be 0.056%. Conclusion: The presence of gallic acid has not yet been reported and quantified in this species which may be utilized for the proper standardization of the drug. The present study showed new natural antioxidant that can replace the synthetic ones to be used in foods and cosmetics. Key words: Antioxidant, DPPH, Myrica Esculenta, Gallic Acid, HPTLC. anti-microbial, 9,10 anxiolytic, 11 while the fruits are known for their anti-oxidant properties and Antimicrobial nature 12,13 The whole plant is an effective chemo preventive agent in skin. Prashant14 Conventionally, foremost tribal communities of Uttarakhand exploit the bark revealing its ethonobotanical importance. It is well known to be effective in chronic cough, asthma and ear ache. When the bark powder is applied externally, it heals chronic and malignant ulcers, and also to intoxicate the fishes. 15 In Ayurveda, the plant is known to have antispasmodic, antiinflammatory, analgesic properties. 16 The antibacterial activity of fruit and bark of the plant has been performed earlier.17 Till now there are so many Synthetic antioxidants are commercially available but quite unsafe, and their toxicity is a distressing trouble. 18 The natural antioxidants, mainly phenolics and flavonoids, are safe, having prominent biological activity, so the current focuses on natural antioxidants from natural plants. Some Reagents used were from Merk (Germany) and standard gallic acid was procured from Sigma-Aldrich (Steinheim). Chromatographic ConditionsChromatography was performed on Merk HPTLC pre coated silica gel 60GF254 (20 X 20 cm) plates. Methano lic solutions of samples and standard compound gallic acid of known concentrations were applied to the layers as 6 mm-wide bands positioned 15 mm from the bot tom and 15 mm from side of the plate, using Camag Linomat V automated TLC applicator with the nitrogen flow providing a delivery speed of 150 nl/s from the application syringe. These conditions were kept constant throughout the analysis of samples. Detection and Quantification of Gallic acidFollowing sample application, l...

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Anxiolytic Properties ofMyrica nagiBark Extract

Cited by 23 publications

References 29 publications

A Review on Ethnomedicinal, Phytochemical and Pharmacological Aspects of Myrica esculenta

A Review on Ethnomedicinal, Phytochemical and Pharmacological Aspects of Myrica esculenta

The Role of Mufarrehat (Exhilarants) in the Management of Depression: An Evidence Based Approach

Pharmacognostic Evaluation and Determination of Secondary Plant Metabolites by HPTLC and its Antioxidant Activity in Myrica esculenta

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