Anti-allergic properties of Mangifera indica L. extract (Vimang) and contribution of its glucosylxanthone mangiferin

Abstract

Vimang is the brand name of formulations containing an extract of Mangifera indica L., ethnopharmacologically used in Cuba for the treatment of some immunopathological disorders, including bronchial asthma, atopic dermatitis and other allergic diseases. However, the effects of Vimang on allergic response have not been reported until now. In this study, the effects of Vimang and mangiferin, a C-glucosylxanthone isolated from the extract, on different parameters of allergic response are reported. Vimang and mangiferin showed a significant dose-dependent inhibition of IgE production in mice and anaphylaxis reaction in rats, histamine-induced vascular permeability and the histamine release induced by compound 48/80 from rat mast cells, and of lymphocyte proliferative response as evidence of the reduction of the amount of B and T lymphocytes able to contribute to allergic response. In these experiments, ketotifen, promethazine and disodium cromoglicate were used as reference drugs. Furthermore, we demonstrated that Vimang had an effect on an in-vivo model of inflammatory allergy mediated by mast cells. These results constitute the first report of the anti-allergic properties of Vimang on allergic models, as well as suggesting that this natural extract could be successfully used in the treatment of allergic disorders. Mangiferin, the major compound of Vimang, contributes to the anti-allergic effects of the extract.

Amaranthus spinosusLinn. inhibits mast cell-mediated anaphylactic reactions

“…In these assays, RPMC were pre-incubated with EAFAS (0.25-1.00 mg/ml) and ketotifen (0.1 mg/ml) at a constant temperature of 37°C for 15 min and then incubated with 0.1 ml Compound 48/80 (10 µg/ml) for 10 min. The doses of EAFAS used here were selected to cover the range of doses successfully utilized by Rivera et al (2006) and Patel et al (2009) in their analyses of these particular mitigating effects by other natural product extracts (specifically, Mangifera indica L. (Vimang) stem bark and Taxus baccata Linn. (AET) leaves, respectively).…”

2,3-Diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: A structure–activity relationship study

“…Later on, Da Re et al 13 reported the analeptic activity of synthetic aminoalkylxanthone derivatives. Since then, the biological profiles of natural and even synthetic analogues have been extensively reported in the literature, namely anti-allergic, 14,15 antifungal, 16,17 anti-inflammatory, 18,19 antimalarial, 20,21 antitumour, 22,23 hepatoprotective activity, 24 inhibition of monoamine oxidase, 25 and other enzymes, like cholinesterase 26 and angiotensin I converting-enzyme. 27 In this broad spectrum of biological activities special mention deserves also the antioxidant 11 activity demonstrated by several xanthones.…”

Antidiarrheal Activity ofLithocarpus dealbata. andUrena lobata. Extracts: Therapeutic Implications

“…The role of quercetin as a promising antidiarrheal molecule has also been verified by several other workers, Galvez (1993b), Galvez et al (1995), and Perrucci et al (2006), to name a few. Similarly, several studies in the past have revealed mangiferin acts against antiinflammatory response by inhibiting the production and release of inflammatory molecules, such as prostaglandins, mast cells, and histamine (Garcia et al, 2003;Rivera et al, 2006). These anti-inflammatory molecules have the ability to relax smooth muscles and thereby relieve the gastrointestinal tract (Katzung, 2004).…”