<i>Amaranthus spinosus</i>Linn. inhibits mast cell-mediated anaphylactic reactions

Patil, Savita D.; Patel, Milap R; Patel, Sachin; Surana, Sanjay J.

doi:10.3109/1547691x.2011.631609

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…The anti-H activity of the A. spinosus extract noted in the current study is in line with the I anti-inflammatory and anti-histaminergic activity of preparations from various parts of A. spinosus in animal models (Olajide et al, 2004;Zeashan et al, 2009;Patil et al, 2012) and their degranulation of rat peritoneal mast cells (Patil et al, 2012). However, A. spinosus leaf extracts also inhibited bronchospasm in laboratory rats and contraction of isolated rabbit trachea caused by carbachol (Chaudhary et al, 2012).…”

Section: Discussionsupporting

confidence: 88%

Evaluation of Surinamese Medicinal Plants for their Potential Bronchospasmolytic Effects in Isolated Guinea Pig Tracheal Chains

Mans¹,

Toelsie²,

Oedairadjs³

et al. 2015

Research J. of Medicinal Plant

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Preparations from the leaves of Kalanchoe pinnata (Lam.) Pers. (Crassulaceae), Asclepias curassavica L. (Asclepiadaceae), Amaranthus spinosus L. (Amaranthaceae), Bixa orellana L. (Bixaceae), Cymbopogon citratus L. (Poaceae), Caesalpinia pulcherrima (L.) Schwartz (Caesalpiniacese) and Solanum jamaicense Mill. (Solanaceae), as well as the peels of Punica granatum L. (Punicaceae), are popularly used in Suriname to relieve respiratory distress. To verify this claim, aqueous extracts from certain parts of these plants were assessed at 0.001-10 mg mLG for their ability to reduce the force of smooth muscle contraction of isolated 1 guinea pig trachea chains induced by acetylcholine (3×10G M) or histamine (10G M). Experiments 5 5 were carried out in Tyrode buffer mixed with 5% CO in air and at 37°C. The extract from 2 K. pinnata (10 mg mLG) reduced the force of contraction of the tracheal chains caused by both 1 acetylcholine and histamine by 40-70%. Those from P. granatum, A. spinosus, A. curassavica and B. orellana (1 and 10 mg mLG) counteracted the force of contraction by histamine by 30-70%. The 1 preparations from C. pulcherrima, C. citratus and S. jamaicense did not affect the force of contraction due to either acetylcholine or histamine. These results suggest that preparations from K. pinnata, A. spinosus, A. curassavica, B. orellana and P. granatum may elicit bronchospasmolytic effects through antagonism of the muscarinic and/or H histamininergic receptor.

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Section: Discussionsupporting

confidence: 88%

Evaluation of Surinamese Medicinal Plants for their Potential Bronchospasmolytic Effects in Isolated Guinea Pig Tracheal Chains

Mans¹,

Toelsie²,

Oedairadjs³

et al. 2015

Research J. of Medicinal Plant

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“…Ethyl acetate fraction of A. spinosus leaves completely inhibited the compound 48/80 secretagogue-induced systemic anaphylactic shock in mouse model. It also stabilized the mast cell lipid bilayer membrane, thereby preventing perturbation of membrane, release of histamine and mast cell degranulation in rat peritoneal mast cells in vitro, suggesting a role in prophylaxis and management of anaphylactic reactions [39]. Kumar et al [11] provided scientific validation that whole plant methanolic extracts of A. caudatus and A. viridis and methanolic leaf extracts of A. spinosus exhibit significant antipyretic effect by reducing yeast-induced elevated body temperature in rats and the results were comparable to standard antipyretic drug paracetamol ( Table 2).…”

Section: Anti-inflammatory and Anti-nociceptive Propertiesmentioning

confidence: 97%

Rediscovering the therapeutic potential of Amaranthus species: A review

Peter

Gandhi

2017

Egyptian Journal of Basic and Applied Sciences

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Extracts of Amaranthus have been used to treat several ailments since ancient times. However, Amaranthus spp. has seen a resurgence of interest in recent decades. Literature summarization of in vitro and in vivo studies established that Amaranthus spp. has several protective and curative properties attributed majorly to strong antioxidant activity. This comprehensive review critically analyzes folklore claims of Amaranthus with scientific evidences, delineating its phytochemical based nutrapharmaceutical properties and emphasizes clinical utility of the plant in various chronic diseases, also defining gap areas for future clinical research. Data on 13 edible Amaranthus spp. was acquired via an electronic search including regional scientific journals, theses, books and government reports. These results provide an in-depth analysis of biological effects of major bioactive ingredients present in crude extracts of specific bioparts. However, bioavailability and underlying mechanism of action of constituents isolated from Amaranthus spp. have not been worked out, thus necessitating focused research in this arena.

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