Antidiarrheal Activity ofLithocarpus dealbata. andUrena lobata. Extracts: Therapeutic Implications

Abstract

This study reports the antidiarrheal potential of Lithocarpus dealbata (Miq.) Rehder (Fagaceae) and Urena lobata L. (Malvaceae) used in the traditional medicine system of the Naga tribes of in India. The antidiarrheal efficacies of the seed extract of L. dealbata and leaf extract of U. lobata were evaluated in murine models by three different approaches: (i) castor oil-induced diarrhea, (ii) PGE 2 -induced enteropooling, and (iii) small intestinal transit. The 800 mg=kg dose of methanol extracts of both plants showed significant (p < 0.001) inhibitor activity against castor oil-induced diarrhea and PGE 2 -induced intrafluid accumulation. Both extracts also showed a significant (p < 0.001) reduction in the gastrointestinal motility in charcoal meal test. Acute toxicity tests did not reveal any sign of toxicity in the animals. The observed results could explain their use as antidiarrheal agents in traditional medicine.

Antidiarrheal mechanism ofCarpolobia lutealeaf fractions in rats

“…The C. lutea fractions did not produce any significant effect on intestinal fluid accumulation. It is likely that the fractions bring out the aforementioned action either through their proabsorptive property that promotes faster fluid absorption in the intestine or through an antisecretory mechanism (Yadav & Tangpu, 2007). The first speculation may gain support 29.24 ± 9.98 a 37.49 Significance relative to control: a p < 0.001; values represent mean ± S.E.M (n = 6).…”

Exploring the Pharmacognostic Characteristics and Antimicrobial Potential of Leaves of Urena Lobata Linn.

“…It is useful for wounds, toothache, gonorrhea and as food for animals as well as humans 14,16,17 . It was also reported that, the plant parts exhibits antioxidant activity 18.19 , cytotoxic activity 19 ,radical scavenging potential 20 , antimicrobial 21 , anti-motility, analgesic, anti-inflammatory, membrane sensitizing activity 22 , immunomodulatory 23,24 , hypoglycemic effect 25 , anti-diarrheal 26 , hypolipidemic 27 and anti-fertility/spermatogenesis effect 28 . …”

A revision on Urena lobata L.

“…The seed extract of U. lobata was found to reduce castor oil-induced diarrhea and prostaglandin E2 (PGE2)-induced intrafluid accumulation in rodents (Yadav & Tangpu 2007). The etha-nol extract of the aerial parts of U. lobata at 250 and 500 mg/kg was also evident to a significant anti-motility activity in charcoalmeal defecation mice (Islam et al 2012).…”