Anti-adipogenic chromone glycosides from Cnidium monnieri fruits in 3T3-L1 cells

Two New Chromone Glycosides from the Roots of Saposhnikovia divaricata

“…The 1 H-NMR spectrum ( Table 1) showed three methyl singlets (d(H) 2.35, 1.34, and 1.33 (each 3H, s)) and two H-atoms singlets (d(H) 6.33 and 6.06 (each H, s)). The NMR data of aglucone moiety of 2 coincided with that of monnieriside G, which indicated that 2 has the same aglucone moiety as monnieriside G. [13] HMBCs (Figure 2) from H-3 to C(2, 4, 10, 2a), H-8 to C (6,7,9,10), H-2 0 to C(4 0 a, 4 0 b), H-3 0 to C(5, 6, 7, 4 0 ), H-4 0 a to C(2 0 , 4 0 b), and H-4 0 b to C(2 0 , 4 0 a) confirmed the skeleton of visamminol. Moreover, HMBC from H-1‴ to C(6″) demonstrated the on-link mode for the apiofuranosyl-(1 ?…”

“…The 13 C‐NMR and DEPT spectra displayed a total of 26 C‐atom resonances, of which 11 O‐bearing C‐atoms ( δ (C) 99.5 ( d ), 75.6 ( d ), 78.5 ( d ), 72.0 ( d ), 76.8 ( d ), 68.5 ( t ), 111.2 ( d ), 78.6 ( d ), 81.0 ( s ), 75.6 ( t ), and 66.2 ( t )), together with two anomeric H‐atoms ( δ (H) 4.55 ( d , J = 7.8) and 4.86 ( d , J = 2.4)) in the 1 H‐NMR spectrum, suggested the same sugar moiety presence as compound 1 . The NMR data of aglucone moiety of 2 coincided with that of monnieriside G, which indicated that 2 has the same aglucone moiety as monnieriside G . HMBCs ( Figure ) from H‐3 to C(2, 4, 10, 2a), H‐8 to C(6, 7, 9, 10), H‐2′ to C(4′a, 4′b), H‐3′ to C(5, 6, 7, 4′), H‐4′a to C(2′, 4′b), and H‐4′b to C(2′, 4′a) confirmed the skeleton of visamminol.…”

“…The positive Molish reaction indicated a glycoside. Its molecular formula was established as C 26 H 34 O 14 by HR-ESI-MS and 13 C-NMR data. The IR spectrum displayed the absorption bands of hydroxy groups at 3410 and 3177 cm À1 , and a carbonyl group at 1672 cm À1 .…”

Potential of the Cnidium monnieri fruits as an immune enhancer in Escherichia coli infection model

“…To date, a number of chemical compounds have been isolated and identified from this plant, these being mainly coumarins such as osthole, imperatorin, bergapten, isopimpinellin, xanthotoxol, xanthotoxin; cnidimonal and cnidimarin; glucosides; sesquiterpenes and so on . Moreover, both in‐vivo and in‐vitro experiments have demonstrated that C. monnieri exhibits a diverse set of potent anti‐allergic, antidermatophytic, anti‐osteoporotic anti‐adipogenic, antibacterial and antifungal activity . Our previous study has shown that C. monnieri has immune‐stimulatory effects in macrophages .…”

8-Alkylcoumarins from the Fruits of Cnidium monnieri Protect against Hydrogen Peroxide Induced Oxidative Stress Damage

“…The dried fruits of C. monnieri , known in Chinese as “Shechuangzi”, have been used as traditional remedies for the skin disease, gynecopathy, and stasis of the blood [1]. Several investigations have reported that the fruits of C. monnieri exhibited various pharmacological effects including antidermatophytic effect [2], antipruritic action [3], anti-allergic effect [4], antiosteoporosis [5], antiproliferation of vascular smooth muscle cells [6], vasorelaxation [7], antifibrotic activity in hepatic cells [8], and anti-adipogenic activity in 3T3-L1 cells [9]. In addition, the chemical constituents including coumarins [10], chromones [11], and sesquiterpens [12], have been isolated from the fruits of C. monnieri .…”