Anthocyanins suppress the secretion of proinflammatory mediators and oxidative stress, and restore ion pump activities in demyelination

Carvalho, Fabiano B.; Gutierres, Jessié Martins; Bohnert, Crystiani; Zago, Adriana Maria; Abdalla, Fátima Husein; Vieira, Juliano Marchi; Palma, Heloísa Einloft; Oliveira, Sara Marchesan; Spanevello, Rosélia Maria; Duarte, Marta Maria Medeiros Frescura; Lopes, Sonia T.A.; Aiello, Graciane; Amaral, Marta; Pippi, Ney Luís; Andrade, Cínthia Melazzo de

doi:10.1016/j.jnutbio.2014.11.006

Cited by 62 publications

(35 citation statements)

References 117 publications

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“…Anthocyanins, particularly, are recognized as an anti-inflammatory and antioxidant agent (Carvalho et al, 2015), besides of other protective effects to human body. This further justifies the use of fruits that are rich in these compounds for the development of new products, which contributes also to their added-value as well as to a healthier diet.…”

Section: Smoothie Sensory Evaluation and Bioactive Compoundsmentioning

confidence: 99%

Sensory evaluation and antioxidant capacity as quality parameters in the development of a banana, strawberry and juçara smoothie

et al. 2017

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On the present study a banana, strawberry and juçara smoothie was developed using an experimental mixture design. The juçara proportion was kept constant while the banana:strawberry ratio varied and the main responses were the sensory acceptability and the antioxidant capacity. From five formulations, only the one with the highest percentage of strawberry was rejected, most likely due to its lower sugar content and higher acidity. On general, panelists chose the sweeter formulations, which were those with a higher percentage of banana. Relating to the consistency, the best formulation was the one containing the same proportion of strawberry and banana pulp, which provided a better flow to the product. Additionally, this sample showed intermediate values of phenolic compounds and antioxidant capacity, as well as desirable physicochemical characteristics. On spite of being possible to obtain four formulations with good sensory acceptance, the one with equal amounts of banana and strawberry pulp is highlighted due to its antioxidant capacity and sensory characteristics, statistically corroborated by the desirability function.Keywords: anthocyanins; Euterpe edulis; mixture experimental design; functional food; juice.Practical Application: This study may contribute to increase the added-value of juçara fruit and the availability of a healthy product for consumers.

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Section: Smoothie Sensory Evaluation and Bioactive Compoundsmentioning

confidence: 99%

Sensory evaluation and antioxidant capacity as quality parameters in the development of a banana, strawberry and juçara smoothie

et al. 2017

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“…Cyanidin is demonstrated to be beneficial against diabetes [4,5], cancer [6][7][8], and atherosclerosis [9]. In the central nervous system, recent investigations indicate that cyanidin showed potential protections against Alzheimer's disease and multiple sclerosis [10,11]. These studies highlighted the implications of cyanidin in the treatment of neurodegenerative disorders.…”

Section: Introductionmentioning

confidence: 99%

Cyanidin Protects SH-SY5Y Human Neuroblastoma Cells from 1-Methyl-4-Phenylpyridinium-Induced Neurotoxicity

et al. 2018

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Cyanidin is an anthocyanidin extracted from a variety of fruits and vegetables. Cyanidin showed benefits against diabetes, cancer, and atherosclerosis. However, the potential neuroprotective effects of cyanidin against Parkinson’s disease (PD) have not been examined. Indicated concentrations of cyanidin (1, 3, 10, and 30 μmol/L) were incubated together with 0.5 mmol/L 1-methyl-4-phenylpyridinium (MPP+) to human neuroblastoma SH-SY5Y cells. We found cyanidin prevented MPP+-induced cell demise in a concentration-dependent manner. Cyanidin significantly reduced MPP+-induced apoptosis, this is reflected by decreased TdT-mediated dUTP nick-end labeling staining and caspase-3 expressions. Further, MPP+ increased the Bax/Bcl-2 ratio, which was partly reversed by cyanidin. We also found cyanidin attenuated the MPP+-induced mitochondrial oxidative stress as revealed by decreased MitoSOX staining. Taken together, these data for the first time indicated the neuroprotective effects of cyanidin against MPP+-induced SH-SY5Y cell death. These findings shed light on the potential implications of cyanidin for PD treatment.

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“…Several studies have identified a number of actions of anthocyanins in a phytochemical diet in the context of neuroinflammation and neurodegeneration in aging individuals. It was also recently reported in an experimental model of multiple sclerosis that anthocyanins (100 mg/kg) could effectively suppress the secretion of pro-inflammatory mediators and protect cellular components against oxidative damages that were induced by demyelination [97]. Anthocyanins also protect neuronal cells from prooxidant and pro-inflammatory damage via the modulation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and the inhibition of NF-κB pathways [98].…”

Section: Anti-inflamm-aging Propertiesmentioning

confidence: 94%

Anthocyanins and Proanthocyanidins in Natural Pigmented Rice and Their Bioactivities

Limtrakul¹,

Semmarath²,

Mapoung³

2020

Phytochemicals in Human Health

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Natural pigmented rice is mainly black, red, and dark purple and contains a variety of flavones, tannins, phenolic, sterols, oryzanols, and essential oils. Anthocyanins and proanthocyanidins belonging to plant flavonoids are thought of as the major functional components found in black, red, and purple rice and contribute to the intense color of many fruits, vegetables, and pigmented cereals such as blueberries, grapes, red cabbages, and purple sweet potatoes. Recent data have indicated the potential for isolating and characterizing the nutrition and nonnutritive components in colored fruits, vegetables, and cereals for their potential chemopreventive and pharmaceutical agents. This chapter provides up-to-date coverage of pigmented rice in terms of the bioactive constituents, isolation, extraction and analytical methods, and related bioactivities. Special focus has been placed on the anti-inflammation, anticancer, and antiaging processes of the major components found in pigmented rice, especially with regard to germ and bran extracts.

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Anthocyanins suppress the secretion of proinflammatory mediators and oxidative stress, and restore ion pump activities in demyelination

Cited by 62 publications

References 117 publications

Sensory evaluation and antioxidant capacity as quality parameters in the development of a banana, strawberry and juçara smoothie

Sensory evaluation and antioxidant capacity as quality parameters in the development of a banana, strawberry and juçara smoothie

Cyanidin Protects SH-SY5Y Human Neuroblastoma Cells from 1-Methyl-4-Phenylpyridinium-Induced Neurotoxicity

Anthocyanins and Proanthocyanidins in Natural Pigmented Rice and Their Bioactivities

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