Anthocyanins in cardioprotection: A path through mitochondria

Liobikas, Julius; Škėmienė, Kristina; Trumbeckaitė, Sonata; Borutaitė, Vilmantė

doi:10.1016/j.phrs.2016.03.036

Cited by 74 publications

(56 citation statements)

References 88 publications

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“…Anthocyanidins are polyphenols found in blueberries, red and black grapes, cranberries, raspberries, blackberries, red cabbage, red onions and eggplants. The mechanism of action of anthocyanins is related to its redox potential that allows it to act as an electron acceptor between complex I of the mitochondrial electron transport system and cyt C. 58,69 Although anthocyanins seem to be electron acceptors in complex I-mediated oxidation of NADH and provide cardioprotection, 70 the effects of this polyphenol have not been tested in the context of CKD. However, using an adenine-induced CKD model in rats recently showed that administration of anthocyanins lessened the effects of adenine-induced CKD.…”

Section: Targeting Mitochondrial Dysfunction In Ckdmentioning

confidence: 99%

Bioactive food and exercise in chronic kidney disease: Targeting the mitochondria

Mafra

Gidlund

Borges

et al. 2018

Eur J Clin Investigation

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Chronic kidney disease (CKD), which affects 10%-15% of the population, associates with a range of complications-such as cardiovascular disease, frailty, infections, muscle and bone disorders and premature ageing-that could be related to alterations of mitochondrial number, distribution, structure and function. As mitochondrial biogenesis, bioenergetics and the dynamic mitochondrial networks directly or indirectly regulate numerous intra-and extracellular functions, the mitochondria have emerged as an important target for interventions aiming at preventing or improving the treatment of complications in CKD. In this review, we discuss the possible role of bioactive food compounds and exercise in the modulation of the disturbed mitochondrial function in a uraemic milieu.

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Section: Targeting Mitochondrial Dysfunction In Ckdmentioning

confidence: 99%

Bioactive food and exercise in chronic kidney disease: Targeting the mitochondria

Mafra

Gidlund

Borges

et al. 2018

Eur J Clin Investigation

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“…Anthocyanins have been shown to be effective in the prevention of arteriosclerosis and cardiovascular diseases [25,40,41,72]. Commercial extracts of Vaccinium myrtillus (bilberry) [120,121] contain glucosides of delphinidin and cyanidin and, since 1977, have been used to inhibit platelet aggregation [122] because of their preventive effect in the initial stage of the formation of thrombi, in the treatment of some diseases related to poor microcirculation resulting from capillary fragility, and also to prevent the oxidation of the LDLs [123][124][125].…”

Section: Flavonoids -From Biosynthesis To Human Health 212mentioning

confidence: 99%

Antioxidant Capacity of Anthocyanin Pigments

Martín¹,

Kuskoski²,

Navas³

et al. 2017

Flavonoids - From Biosynthesis to Human Health

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Anthocyanins are a family of natural pigments classified into the group of flavonoids, considered to be responsible for the color and taste of many fruits and vegetables, i.e. berries. Anthocyanins are common components of the human diet. Besides their interest as colorant because of their coloring properties, the study of anthocyanin compounds stems from their wide applicability in the prevention and even in the treatment of various human diseases. However, various aspects of the pharmacological roles of anthocyanins remain in the dark, having still several obstacles to the development of robust diets or prescribing lines on consumption of anthocyanins. The chemical structure of anthocyanins determines in large measure its capacity and efficacy as an antioxidant agent. In this study, the following aspects are reviewed: the antioxidant effect of anthocyanin pigments; the oxidative stress, the bioavailability after intake and biological aspects of anthocyanins, the method for measuring the antioxidant activity of anthocyanins, the relationship between structure and activity; and the influence of the anthocyanins in the antioxidant activity of wines. Finally an overview of some potential uses in food industry is attempted mainly focusing in the anthocyanin encapsulation topic. Attention has been paid to the more recent publications in the field.

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“…Protective effects of anthocyanins against neurological disorders such as Alzheimer's disease have been reported . Antidiabetic properties have also been described, being attributed mainly to the antioxidant action of anthocyanins, and improvement of cardiovascular health has been related to their consumption . In particular, for strawberry fruits, anti‐inflammatory effects have been reported to be associated with the presence of pelargonidin‐3‐glucoside and cyanidin‐3‐glucoside …”

Section: Introductionmentioning

confidence: 99%

“…7,8 Antidiabetic properties have also been described, being attributed mainly to the antioxidant action of anthocyanins, 9 and improvement of cardiovascular health has been related to their consumption. 8,10,11 In particular, for strawberry fruits, anti-inflammatory effects have been reported to be associated with the presence of pelargonidin-3-glucoside and cyanidin-3-glucoside. 6,12 Metabolic changes in secondary metabolites of F. ananassa have been reported, showing differences between fruits obtained from either organic or conventional agricultural management.…”

Section: Introductionmentioning

confidence: 99%