Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice

Abstract

The anthelmintic effect of tinidazole (100 mg/kg per day for 3 successive days) was tested in male Swiss CF-1 mice infected with second-stage Toxocara canis larvae at challenge doses of 250, 500, 1000, and 1500 embryonated eggs per mouse. The drug was given orally on days 3-5 postinfection (p.i.) to one-half of the animals, and all mice were killed on day 40 p.i. The number of larvae recovered from each mouse's brain and skeletal muscle was then scored in both groups. Tinidazole yielded a highly significant reduction in the total recovery of larvae from the test animals' brains at the second and third inoculum levels but no statistically significant reduction at the highest larval dose as compared with the values obtained in the untreated control animals.

Quality of Medicines Commonly Used in the Treatment of Soil Transmitted Helminths and Giardia in Ethiopia: A Nationwide Survey

“…Literature reports indicate that TNZ, a 5-nitroimidazole compound (S1-1 Supporting information), also has some anthelmintic efficacy [9] , although it is therapeutically mainly used against protozoan infections and infections caused by anaerobic bacteria in humans. As such TNZ is often used by the same patients treated with STH drugs [10] , [11] .…”

Oral treatment with a potential probiotic (Enterococcus faecalisCECT 7121) appears to reduce the parasite burden of mice infected withToxocara canis

“…Mice can be experimentally infected with To. canis and, since humans and rodents are paratenic hosts for the parasite, serve as a useful model of human toxocariasis (Minvielle et al, 1997(Minvielle et al, , 1999a. The numbers of larvae in the liver and lungs of infected mice peak about 48 h post-infection (Basualdo et al, 1995).…”

Toxocariasis in Children: An Update on Clinical Manifestations, Diagnosis, and Treatment

“…59 Other treatments include tinidazole which has been shown to be highly effective in arresting the progression of T. canis larvae to the neurotropic phase of infection. 60 Ivermectin, a member of the macrocyclic lactone endectocides, is a broad-spectrum anthelmintic. When it was tested on 17 consecutive patients with common toxocariasis, it resulted in a 40% reduction in clinical manifestations, but no significant decrease in blood eosinophil count.…”