Anthelmintic activity of Azadirachta indica A. Juss against sheep gastrointestinal nematodes

Costa, C.T.C.; Beviláqua, Cláudia Maria Leal; Maciel, M.V.; Camurça-Vasconcelos, A.L.F.; Morais, Selene Maia de; Monteiro, Maurílio de Abreu; Farias, V.M.; Silva, M.V. da; Souza, M.M.C.

doi:10.1016/j.vetpar.2006.01.002

Cited by 52 publications

(31 citation statements)

References 13 publications

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“…Iqbal et al (2010) noted 29% and 40% reduction in EPG in sheep treated with powder or methanolic extract of A. indica seeds. In this study the daily treatment of heifers with neem cake not significantly decreased EPG as compared with the control group, results similar to those obtained by Chagas et al (2008) that found no effect of treatment with ground dried leaves of A. indica and Costa et al (2006) feeding sheep with dry, crushed leaves of A. indica.…”

Section: Parasitological Datasupporting

confidence: 89%

Weight gain and control of endo- and ectoparasites of beef heifers treated with allopathic, herbal and homeopathic drugs

Catto

Bianchin

Feijó

et al. 2013

Rev. Bras. Parasitol. Vet.

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The aim of this study was to evaluate the efficacy of herbal, homeopathic and allopathic treatments for parasites in beef heifers during two experimental cycles of 318 and 313 days. Treatments: NC -negative control (untreated); HH -treated with homeopathic preparation Homeo bovis Parasitário  ; PC -(positive control) -treated with 10% moxidectina  and an acaricide formulation of cypermethrin, chlorpyrifos and piperonyl butoxide  ; HF -treated with homeopathic preparation Fator C&MC  ; and FN -treated with neem cake (torta de neem  ) and with neem oil (óleo de neem  ). Parasite egg count (EPG), horn fly (Haematobia irritans) and tick (Rhipicephalus (Boophilus) microplus) assessment and animal weighting were performed at 28-day intervals. Blood samples were collected at the first cycle to assess the immune response. Horn fly infestation was not affected by any treatment (P>0.05). The mean number of ticks, which was low in both cycles, was lower (P<0.05) in the first cycle in animals that received PC treatment. In both experimental cycles, the mean EPG of the PC-treated animals was lower (P<0.05) than the animals receiving other treatments. Treatments had no effect on the immune response (P>0.05). The animals treated with allopathic drugs were 22 to 30 kg heavier (P<0.05) than untreated animals or animals treated with alternative drugs.Keywords: Beef cattle, tick, nematodes, horn fly, anthelmintics, alternative control. ResumoO objetivo do trabalho foi avaliar a eficácia de tratamentos fitoterápicos, homeopáticos e alopáticos contra ecto e endoparasitas na recria de novilhas, em dois ciclos experimentais subsequentes de 318 e 313 dias. Tratamentos: CN -controle negativo -não tratado; tratamento HH -tratado com homeopático Homeo bovis Parasitário  ; tratamento CP -controle positivo -tratado com moxidectina 10%  e uma formulação acaricida contendo cypermetrina, clorpirifós e butóxido de piperonila  ; tratamento HF -tratado com homeopático Fator C&MC  e tratamento FN -tratados com torta de neem  e com óleo de neem  . A contagem de ovos nas fezes (OPG), a infestação por Haematobia irritans, Rhipicephalus (Boophilus) microplus e pesagem dos animais foram realizadas em intervalos de 28 dias. No primeiro ciclo foi coletado sangue para avaliar a resposta imume. A infestação por mosca-dos-chifres não foi influenciada por nenhum dos tratamentos (P>0,05). Nos dois ciclos o número médio de carrapatos foi baixo e apenas no primeiro foi menor (P>0.05) no tratamento CP em relação aos demais. A média de OPG no tratamento CP foi mais baixa que nos demais tratamentos nos dois ciclos experimentais (P<0,05). Não houve efeito de tratamentos na resposta imune. Os animais do tratamento CP ganharam entre 22 a 30 kg de peso vivo a mais (P<0,05) que os não tratados ou tratados com medicamentos alternativos.

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Section: Parasitological Datasupporting

confidence: 89%

Weight gain and control of endo- and ectoparasites of beef heifers treated with allopathic, herbal and homeopathic drugs

Catto

Bianchin

Feijó

et al. 2013

Rev. Bras. Parasitol. Vet.

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“…Outros autores como Costa, et al (2006) e Chagas e Vieira (2007) ao administrarem folhas de Neem para ovinos e caprinos respectivamente, 0,1g/kg a 0,2g/kg por 3 meses e 30g/animal/dia por um período de 28 dias, também não observaram diferença significativa entre os grupos tratados e os grupos controles.…”

Section: Resultsunclassified

Efeito do neem (Azadirachta Indica) no controle de nematódeos gastrintestinais em ovinos suplementados a pasto no período seco

Igarashi

Carvalho

Bucci³

et al. 2013

Sem. Ci. Agr.

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Efeito do neem (Azadirachta AbstractThe aim of this study was to evaluated the effect of Azadirachta indica (Neem) extracts upon the productive response and control of gastrointestinal nematodes in Santa Inês sheep during the dry season grazing. Twenty four sheep, were divided in three groups according to the following treatments: SPControl (Animals receiving protein supplement); SP-Oil (Animals receiving protein supplement and Neem oil extract) and SP -Leaf (Animals receiving protein supplement and Neem dry leaves). The animals received daily protein supplement, while the oil and the dry leaves treatments were offered at interval of 15 days, a total of 4 doses ministred. Each day of supply of oil and leaves, feces samples were

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“…The neem tree (Azadirachta indica) is known for its medicinal properties and has been recommended for use against gastro-intestinal nematodes and related problems in many parts of the world (Biswas et al, 2002;Subapriya and Nagini, 2005). However, when leaves of the neem tree were offered to parasitised sheep, either fresh or dried, no anthelmintic effect was recorded against H. contortus (Githiori et al, 2004;Costa et al, 2006). In contrast, in another study, Chandrawathani et al (2006) reported the effectiveness of neem in reducing worm numbers of the same nematode in the abomasa of small ruminants fed on fresh neem leaves on a daily basis.…”

Section: Studies On the Whole Plant: Strengths And Limitationsmentioning

confidence: 99%

“…Possibly due to cost implications and design limitations, condensed tannin content and plant description was not included in any of the studies previously mentioned (Chandrawathani et al, 2002 and2006;Githiori et al, 2004;Costa et al, 2006). This would have helped towards accounting for the potential inconsistencies among the different studies.…”

Section: Studies On the Whole Plant: Strengths And Limitationsmentioning

confidence: 99%

Medicinal plants for helminth parasite control: facts and fiction

Athanasiadou

Githiori

Kyriazakis

2007

Animal

190

123

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The use of medicinal plants for the prevention and treatment of gastro-intestinal parasitism has its origin in ethnoveterinary medicine. Although until recently the majority of the evidence on the antiparasitic activity of medicinal plants was anecdotal and lacked scientific validity, there is currently an increasing number of controlled experimental studies that aim to verify and quantify such plant activity. There are indeed a large number of plants whose anthelmintic activity has been demonstrated under controlled experimentation, either through feeding the whole plant or administering plant extracts to parasitised hosts. However, contrary to traditional expectation, there are also a great number of plants with purported antiparasitic properties, which have not been reproduced under experimental conditions. In this paper, we discuss the source of such inconsistencies between ethnoveterinary wisdom and scientific experimentation. We focus on the strengths and weaknesses of the existing methodologies used in the controlled studies to determine the activity of antiparasitic plants. We discuss issues like the seasonal and environmental variability of the plant composition, and how this can affect their antiparasitic properties and highlight the importance of identifying the mechanisms of action of such plants and the target parasite species. In addition to their antiparasitic properties, medicinal plants may also have anti-nutritional properties, which can affect animal performance and behaviour. For this reason, we emphasise the need for considering additional dimensions when evaluating medicinal plants. We also question whether using similar criteria as those used for the evaluation of anthelmintics is the way forward. We propose that a holistic approach is required to evaluate the potential of medicinal plants in parasite control and maximise their benefits on parasitised hosts. Keywords: bioactive plants, ethnoveterinary medicine, medicinal plants, parasites, ruminants IntroductionFor centuries, medicinal plants have been used to combat parasitism, and in many parts of the world are still used for this purpose. In ethnoveterinary medicine, which draws inspiration from traditional practice, there seems to be a range of plant/s or plant extract suitable for treating almost every parasitic disease of livestock (International Institute of Rural Reconstruction (IIRR), 1994). For example, seeds of garlic, onion and mint have been used to treat animals that suffer from gastro-intestinal parasitism, whereas extracts of the tobacco plant have been used to treat the skin of livestock afflicted with external parasites (Guarrera, 1999). Leaves, dried flowers and oil from Chenopodium ambrosioides, a shrub that originated from Central America and has been distributed around the world, have all been used as anthelmintics since the early 1900s (Guarrera, 1999).Reports from around the world include exhaustive lists of plants that have been reported to have medicinal properties (Hammond et al., 1997;Akhtar et al., 2000;Waller ...

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Anthelmintic activity of Azadirachta indica A. Juss against sheep gastrointestinal nematodes

Cited by 52 publications

References 13 publications

Weight gain and control of endo- and ectoparasites of beef heifers treated with allopathic, herbal and homeopathic drugs

Weight gain and control of endo- and ectoparasites of beef heifers treated with allopathic, herbal and homeopathic drugs

Efeito do neem (Azadirachta Indica) no controle de nematódeos gastrintestinais em ovinos suplementados a pasto no período seco

Medicinal plants for helminth parasite control: facts and fiction

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