Anterior spinal column augmentation with injectable bone cements

Verlaan, Jorrit‐Jan; Oner, F. Cumhur; Dhert, W.J.A.

doi:10.1016/j.biomaterials.2005.07.028

Cited by 56 publications

(34 citation statements)

References 121 publications

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“…As result, research in this particular area is being pushed forward in order to obtain further improvements (1). Minimal invasive surgery can be used to repair some damaged areas involving the procedure itself alone (endoscopy, thoroscopy and laparoscopy) or the procedure associated with injection of materials to fill defects and/or to deliver drugs.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Polymeric Solutions as Injectable Vehicles for Hydroxyapatite Microspheres

et al. 2010

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Abstract.A polymeric solution and a reinforcement phase can work as an injectable material to fill up bone defects. However, the properties of the solution should be suitable to enable the transport of that extra phase. Additionally, the use of biocompatible materials is a requirement for tissue regeneration. Thus, we intended to optimize a biocompatible polymeric solution able to carry hydroxyapatite microspheres into bone defects using an orthopedic injectable device. To achieve that goal, polymers usually regarded as biocompatible were selected, namely sodium carboxymethylcellulose, hydroxypropylmethylcellulose, and Na-alginate (ALG). The rheological properties of the polymeric solutions at different concentrations were assessed by viscosimetry before and after moist heat sterilization. In order to correlate rheological properties with injectability, solutions were tested using an orthopedic device applied for minimal invasive surgeries. Among the three polymers, ALG solutions presented the most suitable properties for our goal and a non-sterile ALG 6% solution was successfully used to perform preliminary injection tests of hydroxyapatite microspheres. Sterile ALG 7.25% solution was found to closely match non-sterile ALG 6% properties and it was selected as the optimal vehicle. Finally, sterile ALG 7.25% physical stability was studied at different temperatures over a 3-month period. It was observed that its rheological properties presented minor changes when stored at 25°C or at 4°C.

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Section: Introductionmentioning

confidence: 99%

Characterization of Polymeric Solutions as Injectable Vehicles for Hydroxyapatite Microspheres

et al. 2010

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“…Many reports about successful application of bone substitutes exist [8,12,21,[26][27][28][29]; however, in particular cases, excessive inflammatory reactions were noticed. This sporadically led to damage of the surrounding soft tissue, implant failure, and infection [7, 9-11, 30, 31]; therefore, our study tries to find out if there is coherence between implant failure and the type of used material.…”

Section: Discussionmentioning

confidence: 99%

Microvascular response to calcium phosphate bone substitutes: an intravital microscopy analysis

Roetman

Ring

Langer

et al. 2010

Langenbecks Arch Surg

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“…However the optimal relationship between cement distribution and strength properties has hitherto only been explored in an empirical manner. Studies have investigated the use of PMMA [ 44,32,18,6,10,20] while others have investigated the use of calcium phosphate cements [14,29] or calcium sulphate cements [24,22] and compared these bioresorbable/biodegradable cements to PMMA [22,35]. Page 4 Many of the studies are based on in vitro tests.…”

Section: Review Of Literaturementioning

confidence: 99%

“…The technique has been used where there is poor bone quality primarily in spinal and traumatology applications [16,26,22,44]. However, despite the apparent widespread clinical use, the practice of screw augmentation appears to be largely empirical and trial and error is most often used to establish the amount and the position of the cement.…”

Section: Review Of Literaturementioning

confidence: 99%

An approximate model for cancellous bone screw fixation

Brown¹,

Sinclair²,

Day³

et al. 2013

Computer Methods in Biomechanics and Biomedical Engineering

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This paper presents a finite element (FE) model to identify parameters that affect the performance of an improved cancellous bone screw fixation technique, and hence potentially improved fracture treatment. In cancellous bone of low apparent density it can be difficult to achieve adequate screw fixation and hence provide stable fracture fixation that enables bony healing. Data from predictive FE models indicate that cements can have significant potential to improve screw holding power in cancellous bone. These FE models are used to demonstrate the key parameters that determine pullout strength in a variety of screw, bone, and cement set-ups, and to compare the effectiveness of different configurations. The paper concludes that significant advantages, up to an order of magnitude, in screw pull-out strength in cancellous bone might be gained by the appropriate use of a currently-approved calcium phosphate cement.

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Anterior spinal column augmentation with injectable bone cements

Cited by 56 publications

References 121 publications

Characterization of Polymeric Solutions as Injectable Vehicles for Hydroxyapatite Microspheres

Characterization of Polymeric Solutions as Injectable Vehicles for Hydroxyapatite Microspheres

Microvascular response to calcium phosphate bone substitutes: an intravital microscopy analysis

An approximate model for cancellous bone screw fixation

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