Anterior segment optical coherence tomography imaging and histopathologic findings of an overhanging filtering bleb

Kim, W K; Seong, Gong Je; Lee, Christopher Seungkyu; Kim, Y G; Kim, C Y

doi:10.1038/eye.2008.166

Cited by 15 publications

(10 citation statements)

References 5 publications

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“…In a clinical situation, AS-OCT was applicable for determining which blebs were suitable for needling [ 67 ] and which could be used to evaluate the bleb change after laser suture lysis [ 68 ]. Moreover, it provided detailed information when planning bleb revision surgery for overhanging filtering bleb [ 69 ]. In author's opinion, AS-OCT may also be helpful for distinguishing the “real” tube erosion of glaucoma implant surgery because of its noncontact nature ( Figure 13 ).…”

Section: Glaucoma: Assessment Of the Filtering Bleb And Tubementioning

confidence: 99%

Clinical Applications of Anterior Segment Optical Coherence Tomography

Lim

2015

Journal of Ophthalmology

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Anterior segment optical coherence tomography (AS-OCT) was recently developed and has become a crucial tool in clinical practice. AS-OCT is a noncontact imaging device that provides the detailed structure of the anterior part of the eyes. In this review, the author will discuss the various clinical applications of AS-OCT, such as the normal findings, tear meniscus measurement, ocular surface disease (e.g., pterygium, pinguecula, and scleromalacia), architectural analysis after cataract surgery, post-LASIK keratectasia, Descemet's membrane detachment, evaluation of corneal graft after keratoplasty, corneal deposits (corneal dystrophies and corneal verticillata), keratitis, anterior segment tumors, and glaucoma evaluation (angle assessment, morphological analysis of the filtering bleb after trabeculectomy, or glaucoma drainage device implantation surgery). The author also presents some interesting cases demonstrated via AS-OCT.

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Section: Glaucoma: Assessment Of the Filtering Bleb And Tubementioning

confidence: 99%

Clinical Applications of Anterior Segment Optical Coherence Tomography

Lim

2015

Journal of Ophthalmology

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“…Patients also generally complain of poor cosmesis [ 4 ]. Excision of overhanging filtering blebs is recommended for patients with seriously compromised comfort and visual function [ 1 , 2 , 5 ]. However, how it developed is debated.…”

Section: Introductionmentioning

confidence: 99%

Histopathology and treatment of a huge overhanging filtering bleb

Ouyang

Duan

2016

BMC Ophthalmol

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BackgroundThe giant filtering bleb encroaching onto the corneal surface is a rare occurrence in our and other’s clinical experience (Kapoor and Syed, Int. Ophthalmol 31(5):403–404, 2011), even in patients having had a trabeculectomy with mitomycin C, and how it developed is debated. In this paper, we report a patient who developed a huge overhanging filtering bleb after trabeculectomy, and present our intraoperative photographs, histopathology and immunohistochemistry results.Case presentationA 62-year-old female visited our hospital due to the giant filtering bleb encroaching onto the corneal surface which was about 6 mm × 8 mm × 3 mm. We dissected the filtering bleb from the cornea and present the histopathology and immunohistochemistry results of it.ConclusionThe results from histopathology and immunohistochemistry in this study are consistent with the filtering cicatrix hypothesis. However, our finding that the overhanging blebs had tight connections with the corneal tissue or corneoscleral limbus, rather than simply leaning on it, might be highly related to their development and still needs to be further studied.Electronic supplementary materialThe online version of this article (doi:10.1186/s12886-016-0353-7) contains supplementary material, which is available to authorized users.

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“…Guthoff et al demonstrated the use of AS‐OCT in selecting blebs for needling and analysis after laser suture lysis . Kim et al showed AS‐OCT can be implemented in surgically correcting overhanging filtering blebs . AS‐OCT can also be used to monitor filtering blebs and tubes in the early post‐operative stage…”

Section: Resultsmentioning

confidence: 99%

Anterior segment optical coherence tomography and its clinical applications

Wang

Cornish

Grigg

et al. 2019

Clinical and Experimental Optometry

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Anterior segment optical coherence tomography (AS-OCT) has become one of the cornerstones of non-contact imaging modalities for assessing such structures as the cornea, anterior chamber angle, aqueous outflow pathway, sclera, and ocular surface structures. As such, it has a broad range of clinical applications, which have been independently reported in the literature. This paper aims to present a review of extant literature on the utility of AS-OCT and its efficacy in clinical applications, and to evaluate the quality of available evidence. The following databases were searched from inception to 24 June 2018: Medline via Ovid, Cochrane Central Register of Controlled Trials, PubMed, World Health Organization International Clinical Trials Registry Platform, EMBASE, and CINAHL. Bibliographies of identified papers were hand searched. Inclusion criteria: articles describing or assessing the use of OCT for visualising the AS. The authors excluded studies without an identified primary outcome variable. One author independently selected studies, extracted data, and assessed for risk of bias using PRISMA guidelines. This review included 82 studies, of which there were 11 cohort studies, 37 case series, 10 case studies, 21 comparative observational studies, and three non-systematic review articles. Primary outcome variables included anterior chamber angle, angle opening distance, angle recess area, trabecular iris angle, trabeculairis space area, corneal thickness, tear meniscus height, tear meniscus area, tear meniscus volume, and the morphology of AS structures, including the ocular surface, blebs, flaps, and graft sites. This review attempts to encompass the breadth and depth of evidence for AS-OCT in the arena of diagnostics, therapeutics, and prognostics. At the same time, it brings to light the dearth of high-level evidence on this topic, suggesting the important role of randomised controlled trials and meta-analyses for the future validation of this technology.

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Anterior segment optical coherence tomography imaging and histopathologic findings of an overhanging filtering bleb

Cited by 15 publications

References 5 publications

Clinical Applications of Anterior Segment Optical Coherence Tomography

Clinical Applications of Anterior Segment Optical Coherence Tomography

Histopathology and treatment of a huge overhanging filtering bleb

Anterior segment optical coherence tomography and its clinical applications

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