Clinical Applications of Anterior Segment Optical Coherence Tomography

Lim, Su-Ho

doi:10.1155/2015/605729

Cited by 51 publications

(46 citation statements)

References 70 publications

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“…It allows quantitative analyses such as tear meniscus measurements and therefore may be useful and applicable for DED diagnosis and evaluation (Ibrahim et al. ; Lim ).…”

Section: Clinical Data Supporting Inflammation In Dedmentioning

confidence: 99%

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Clinical impact of inflammation in dry eye disease: proceedings of the ODISSEY group meeting

Baudouin

İrkeç

Messmer

et al. 2017

Acta Ophthalmologica

123

141

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Dry eye disease (DED) is a common, multifactorial ocular condition with major impact on vision and quality of life. It is now well recognized that the pathophysiology of chronic DED can include a cycle of inflammation involving both innate and adaptive immune responses. Recently, in vitro/in vivo models have been used to obtain a better understanding of DED‐related inflammatory processes at molecular/cellular levels although they do not truly reproduce the complex and chronic hallmarks of human DED. In clinical DED research, advanced techniques such as impression cytology, conjunctival biopsy, in vivo confocal microscopy and multiplex tear analyses have allowed an improved assessment of inflammation in DED patients. This was supported by the identification of reliable inflammatory markers including matrix metalloproteinase‐9, human leucocyte antigen‐DR or intercellular adhesion molecule‐1 in tears and impression cytology samples. One of the current therapeutic strategies focuses on breaking the inflammatory cycle perpetuating the ocular surface disease, and preclinical/clinical research has led to the development of promising anti‐inflammatory compounds. For instance, cyclosporine, already approved in the United States, has recently been authorized in Europe to treat DED associated with severe keratitis. In addition, other agents such as corticosteroids, doxycycline and essential fatty acids, through their anti‐inflammatory properties, show encouraging results. We now have a clearer understanding of the inflammatory processes involved in DED, and there is hope that the still emerging preclinical/clinical findings will be translated into new and highly effective therapies for patients in the near future.

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“…It allows quantitative analyses such as tear meniscus measurements and therefore may be useful and applicable for DED diagnosis and evaluation (Ibrahim et al. ; Lim ).…”

Section: Clinical Data Supporting Inflammation In Dedmentioning

confidence: 99%

“…This technique is a noncontact optical system that captures cross-sectional images of the cornea and anterior chamber. It allows quantitative analyses such as tear meniscus measurements and therefore may be useful and applicable for DED diagnosis and evaluation (Ibrahim et al 2010;Lim 2015).…”

Section: Imaging Techniquesmentioning

confidence: 99%

Clinical impact of inflammation in dry eye disease: proceedings of the ODISSEY group meeting

Baudouin

İrkeç

Messmer

et al. 2017

Acta Ophthalmologica

123

141

View full text Add to dashboard Cite

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“…Nanji et al reported similar findings using ultra‐high‐resolution OCT . AS‐OCT is also able to distinguish between pterygium, pseudopterygium (in which the overlying membrane remains detached from the cornea), and pinguecula (in which the overgrowth terminates at the limbus)…”

Section: Resultsmentioning

confidence: 72%

“…OCT is an imaging modality that produces two‐ and three‐dimensional cross‐sectional imaging of tissue, by conglomerating multiple axial scans into a composite B‐scan image . For AS imaging, it is advantageous to use a longer wavelength (1,050– 1,310 nm) than retinal OCT (800–900 nm), due to the resultant minimisation in scattering and higher penetration . This is important in visualising the structures in the vicinity of the iridocorneal angle, including the scleral spur and iris root …”

mentioning

confidence: 99%

Anterior segment optical coherence tomography and its clinical applications

Wang

Cornish

Grigg

et al. 2019

Clinical and Experimental Optometry

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Anterior segment optical coherence tomography (AS-OCT) has become one of the cornerstones of non-contact imaging modalities for assessing such structures as the cornea, anterior chamber angle, aqueous outflow pathway, sclera, and ocular surface structures. As such, it has a broad range of clinical applications, which have been independently reported in the literature. This paper aims to present a review of extant literature on the utility of AS-OCT and its efficacy in clinical applications, and to evaluate the quality of available evidence. The following databases were searched from inception to 24 June 2018: Medline via Ovid, Cochrane Central Register of Controlled Trials, PubMed, World Health Organization International Clinical Trials Registry Platform, EMBASE, and CINAHL. Bibliographies of identified papers were hand searched. Inclusion criteria: articles describing or assessing the use of OCT for visualising the AS. The authors excluded studies without an identified primary outcome variable. One author independently selected studies, extracted data, and assessed for risk of bias using PRISMA guidelines. This review included 82 studies, of which there were 11 cohort studies, 37 case series, 10 case studies, 21 comparative observational studies, and three non-systematic review articles. Primary outcome variables included anterior chamber angle, angle opening distance, angle recess area, trabecular iris angle, trabeculairis space area, corneal thickness, tear meniscus height, tear meniscus area, tear meniscus volume, and the morphology of AS structures, including the ocular surface, blebs, flaps, and graft sites. This review attempts to encompass the breadth and depth of evidence for AS-OCT in the arena of diagnostics, therapeutics, and prognostics. At the same time, it brings to light the dearth of high-level evidence on this topic, suggesting the important role of randomised controlled trials and meta-analyses for the future validation of this technology.

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“…Günümüzde ön segment OKT, gözyaşı film tabakası ve menisküsünün değerlendirilmesinde, pterjium, korneal distrofiler gibi oküler yüzey hastalıklarının değerlendirilmesinde, kontakt lensin kornea ve konjonktiva ile ilişkisinin değerlendirilmesinde, katarakt, refraktif, keratoplasti ve glokom cerrahileri sonrası oküler yüzeyin ve intraoküler yapıların değerlendiril-mesinde kullanılmaktadır [4].…”

Section: Introductionunclassified

The Effects of Gender, Age, and Refractive Error on Corneal and Conjunctival Epithelial and Overall Thicknesses

Erşan

Kara²,

Arıkan³

et al. 2016

J Clin Exp Invest

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ÖZETAmaç: Sağlıklı kişilerde kornea, konjonktiva epitel ve total kalınlıklarının ön segment optik koherens tomografi (OKT) ile değerlendirilmesi.Yöntemler: Anterior Segment 5 Line Raster protokolü ile Cirrus HD-OKT görüntülemesi yapılan 134 sağlıklı kişinin 134 gözü retrospektif olarak bu çalışmaya dahil edildi. Korneal, konjonktival epitel ve total kalınlıkları OKT görüntüleri üzerinden ölçüldü. Cinsiyet ve yaşa göre oluşturulan alt gruplar arasında bu dört OKT parametresinin ortalamaları karşılaştırıldı. Bulgular:Ortalama kornea epitel ve total kalınlığı sırasıyla 51,30±4.60 µm, 532,47±37,30 µm idi. Ortalama konjonktiva epitel ve total kalınlığı sırasıyla 47,20±8,03 µm, 237,07±40,62 µm idi. Tüm ölçümler erkeklerde kadınlara göre kalın olsa da anlamlı fark sadece kornea epitelinde gözlendi (p=0,043). Spearman korelasyon analizinde santral kornea kalınlığı ve konjonktiva epitel kalınlığı ile yaş (sırasıyla p=0,006 ve p= 0,005) ve kırma kusuru (sırasıyla p=0,040 ve p=0,033) arasında negatif korelasyon görüldü.Sonuç: Ön segment OKT ile ölçülen bazı oküler yüzey parametreleri cinsiyet, yaş ve kırma kusuruyla ilişkilidir. Bu yüz-den kornea ve konjonktivanın değerlendirileceği sonraki çalışmalarda cinsiyet, yaş ve kırma kusuru benzer olan kontrol grupları kullanılmalıdır. Methods: This retrospective study included 134 eyes of 134 healthy individuals who were undergone a Cirrus HD-OCT examination using the Anterior Segment 5 Line Raster protocol. Corneal, conjunctival epithelial and overall thicknesses were measured on OCT images. The average values of four OCT parameters were compared between sexes and among the six subgroups with respect to age. Results:The average corneal epithelial and overall thicknesses were 51.30±4.60 µm and 532.47±37.30 µm, respectively. The average conjunctival epithelial and overall thicknesses were 47.20±8.03 µm and 237.07±40.62 µm, respectively. All of the measurements were thicker in males compared to females, however the significant difference was found for only corneal epithelium (p=0.043). Using the Spearman correlation coefficient, central corneal and conjunctival epithelial thicknesses showed significant negative correlations with age (p=0.006, p=0.005, respectively) and refraction (p=0.040, p=0.033, respectively). Conclusion:Ocular surface parameters measured by anterior segment OCT were gender, age, and refraction-related. Thus, further studies conducted to evaluate the corneal and conjunctival thicknesses should involve gender, age, and refraction-matched control groups. J Clin Exp Invest 2016; 7 (1): 78-82

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Clinical Applications of Anterior Segment Optical Coherence Tomography

Cited by 51 publications

References 70 publications

Clinical impact of inflammation in dry eye disease: proceedings of the ODISSEY group meeting

Clinical impact of inflammation in dry eye disease: proceedings of the ODISSEY group meeting

Anterior segment optical coherence tomography and its clinical applications

The Effects of Gender, Age, and Refractive Error on Corneal and Conjunctival Epithelial and Overall Thicknesses

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