Antagonism of the stimulant and depressant effects of ethanol in rats by naloxone

Prunell, M; Boada, J; Feria, Manuel; Benitez, Maria-José

doi:10.1007/bf00177918

Cited by 28 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was evidence of a small locomotor stimulant effect of 30-minute immersion in 0.1 M EtOH as reflected in a significant increase in Center speed. This is consistent with observations in the rat in which lower doses produce locomotor stimulation while higher doses suppress activity (Prunell et al, 1987). There was no indication of a more robust stimulant effect of 0.05 M immersion, see Supplemental Figure S5 .…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Behavioral effects of ethanol in the Red Swamp Crayfish (Procambarus clarkii)

Gutierrez

Creehan

Guglielmo

et al. 2021

Preprint

View full text Add to dashboard Cite

Alcohol abuse and dependence remains one of the primary preventable sources of human mortality in the United States. Model laboratory species can be used to evaluate behavioral, neuropharmacological and other biological changes associated with alcohol exposure and to identify novel treatment modalities. This report describes methods for evaluating the behavioral effects of ethyl alcohol (ethanol; EtOH) in a crayfish model. Crayfish (Procambarus clarkii) were immersed in ethanol baths with concentrations ranging from 0.1 to 1.0 molar, and for durations of 10-30 minutes. Studies evaluated hemolymph alcohol concentration, locomotor behavior in an open field and anxiety-like behavior using a Light/Dark transfer approach. EtOH immersion produced dose dependent increases in hemolymph EtOH concentration (up to 249 mg/dL) and reductions in open field locomotor behavior that depended on EtOH concentration or exposure duration. Under baseline conditions, crayfish exhibit avoidance of the open parts of the locomotor arena and a preference for the covered portion, when available. Acute EtOH immersion decreased time spent in the covered portion of the Light/Dark arena, consistent with a decrease in anxiety-like behavior. EtOH immersion once per day for 5 days did not alter the acute locomotor behavioral response, however increased activity was observed 3 days after the repeated EtOH regimen. Overall, this study shows that this inexpensive, easily maintained species can be used for behavioral pharmacological experiments designed to assess the acute and repeated effects of EtOH.

show abstract

Section: Discussionsupporting

confidence: 92%

“…It was found that 2 g/kg, p.o. increases activity in rats, whereas 4 g/kg was reported to decrease activity (Prunell et al, 1987). Similarly 2 g/kg EtOH, i.p., decreased motor activity in 20, 40 or 60 day old rats (Lamble and Rydberg, 1982) and 0.75 g/kg, i.p.…”

Section: Introductionmentioning

confidence: 99%

Behavioral effects of ethanol in the Red Swamp Crayfish (Procambarus clarkii)

Gutierrez

Creehan

Guglielmo

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Our results showed that naloxone prevented the improving effect of ethanol on memory recall. According to Prunell et al (1987) both the CNS stimulant and depressant effects of ethanol in rats have been antagonized by naloxone. However, other investigators suggested that the effects of naloxone are probably due to a non-specific analeptic action rather than blockade of opioid receptors (Saddler et al, 1985).…”

Section: Discussionmentioning

confidence: 99%

Effect of Ethanol on Morphine State-Dependent Learning in the Mouse: Involvement of Gabaergic, Opioidergic and Cholinergic Systems

Vakili¹,

Tayebi²,

Jafari³

et al. 2004

Alcohol and Alcoholism

View full text Add to dashboard Cite

show abstract

“…Though the particular alleles and gene products contributing to EtOH induced locomotor changes remain obscure (Phillips et al, 1995), opioid peptides have been implicated (Prunell et al, 1987; Kuribara et al, 1991; Sanchis-Segura and Aragon, 2002; Sanchis-Segura et al, 2005). In this study we evaluated the effect of β-E on the development of locomotor sensitization to repeated EtOH exposure using transgenic mice that vary in their capacity to synthesize the peptide.…”

Section: Introductionmentioning

confidence: 99%

Locomotor sensitization to EtOH: contribution of β-Endorphin

Dempsey¹,

Grisel²

2012

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Alcohol use disorders, like all drug addictions, involve a constellation of adaptive changes throughout the brain. Neural activity underlying changes in the rewarding properties of alcohol reflect changes in dopamine transmission in mesolimbic and nigrostriatal pathways and these effects are modulated by endogenous opioids such as β-Endorphin. In order to study the role of β-Endorphin in the development of locomotor sensitization to repeated EtOH exposure, we tested transgenic mice that vary in their capacity to synthesize this peptide as a result of constitutive modification of the Pomc gene. Our results indicate that mice deficient in β-Endorphin show attenuated locomotor activation following an acute injection of EtOH (2.0 g/kg) and, in contrast to wildtype mice, fail to demonstrate locomotor sensitization after 12 days of repeated EtOH injections. These data support the idea that β-Endorphin modulates the locomotor effects of EtOH and contributes to the neuroadaptive changes associated with chronic use.

show abstract

Antagonism of the stimulant and depressant effects of ethanol in rats by naloxone

Cited by 28 publications

References 27 publications

Behavioral effects of ethanol in the Red Swamp Crayfish (Procambarus clarkii)

Behavioral effects of ethanol in the Red Swamp Crayfish (Procambarus clarkii)

Effect of Ethanol on Morphine State-Dependent Learning in the Mouse: Involvement of Gabaergic, Opioidergic and Cholinergic Systems

Locomotor sensitization to EtOH: contribution of β-Endorphin

Contact Info

Product

Resources

About