Effect of Ethanol on Morphine State-Dependent Learning in the Mouse: Involvement of Gabaergic, Opioidergic and Cholinergic Systems

Vakili, Arsalan; Tayebi, K.; Jafari, Mohammad-Reza; Zarrindast, Mohammad Reza; Djahanguiri, B

doi:10.1093/alcalc/agh084

Cited by 25 publications

(8 citation statements)

References 37 publications

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“…Another important feature of pretraining morphineinduced amnesia in avoidance tasks is that it is abolished by pretesting administration of this drug (Izquierdo and Dias 1983;Bruins Slot and Colpaert 1999a;Khavandgar et al 2002Khavandgar et al , 2003Jafari et al 2004;Mohammad-Reza and Rezayof 2004;Vakili et al 2004). This phenomenon is called state dependence, i.e., the retrieval of learned information requires that the animal be in a state similar to that in which the memory for this information was acquired (Izquierdo et al 1981;Bruins Slot and Colpaert 1999a), and has been demonstrated after administration of several psychoactive drugs (Colpaert 1990;Jackson et al 1992;Bruins Slot et al 1999;Colpaert et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Effects of morphine on the plus-maze discriminative avoidance task: role of state-dependent learning

et al. 2005

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Section: Introductionmentioning

confidence: 99%

Effects of morphine on the plus-maze discriminative avoidance task: role of state-dependent learning

et al. 2005

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“…Several drugs have been demonstrated, in our laboratory and by other investigators, to replace the pre-testing effect of morphine on the restoration of memory, e.g. adenosine [19] , nitric oxide [20] , ␣ -adrenoceptor drugs [21] , K ATP channel modulators [22] , glucose and insulin [23] and ethanol [24] .…”

Section: Discussionmentioning

confidence: 93%

Influence of Intracerebroventricular Administration of Histaminergic Drugs on Morphine State-Dependent Memory in the Step-Down Passive Avoidance Test

Zarrindast¹,

Khalilzadeh²,

Rezayat³

et al. 2005

Pharmacology

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The effects of histaminergic drugs on morphine state-dependent memory of a passive avoidance task were examined in mice. Pre-training administration of morphine (5 mg/kg) led to state-dependent learning with impaired memory recall on the test day which was reversed by pre-test administration of the same dose of the opioid. The pre-test intracerebroventricular (i.c.v.) administration of the H₁ blocker (pyrilamine) prevented the restoration of memory by morphine. The H₂ blocker (ranitidine) was ineffective in this regard and the H₃ blocker (clobenpropit) potentiated the effect of morphine on memory recall. The pre-test i.c.v. administration of histamine alone (5, 10, and 20 µg/mouse) not only mimicked the effect of pre-test morphine treatment, but also increased this action of the opioid. The effect of histamine on memory recall was not changed by the pre-test administration of µ-opioid receptor antagonist, naloxone. In conclusion, the improvement of memory recall by morphine treatment, on the test day, seems to be, at least in part, through the release of histamine followed by the stimulation of H₁ receptors. Histamine by itself, when administered on the test day, mimicked morphine-induced memory improvement by a mechanism independent of the µ-opioid receptors.

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“…Several other drugs have been demonstrated to improve memory impairment induced by pre-training morphine, when administered on the pre-test day, e.g. adenosine [21] , nitric oxide [22] , ␣ -adrenoceptor drugs [20] , K ATP channel modulators [23] , glucose and insulin [24] , ethanol [25] and histamine [26] .…”

Section: Discussionmentioning

confidence: 99%

“…In this experiment, the first group of animals received saline (10 ml/kg) 30 min post-training and sulpiride (25,50 and 100 mg/ kg) 30 min before testing. The second group of animals received morphine (5 mg/kg, s.c.) 30 min post-training and sulpiride 45 min plus morphine 30 min before testing ( fig.…”

Section: Methodsmentioning

confidence: 99%

Effects of Clozapine and Sulpiride on Morphine State-Dependent Memory in the Step-Down Passive Avoidance Test

et al. 2006

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The effects of antipsychotic drugs sulpiride and clozapine on morphine state-dependent memory of passive avoidance task were examined in mice. Post-training administration of morphine (5 mg/kg) led to state-dependent learning with impaired memory retrieval on the test day which was reversed by pre-test administration of the same dose of the opioid (5 mg/kg). In animals where memory was impaired by post-training morphine, the administration of either sulpiride or clozapine before pre-test morphine reduced the improvement of memory produced by the opioid. Co-administration of sulpiride with clozapine did not potentiate their antagonistic response. In conclusion, the inhibition of improvement of memory retrieval by morphine treatment on the test day by the two dopamine receptor antagonists seems to be induced through two different receptor mechanisms.

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Effect of Ethanol on Morphine State-Dependent Learning in the Mouse: Involvement of Gabaergic, Opioidergic and Cholinergic Systems

Abstract: GABAergic, endogenous opioidergic and cholinergic systems are involved in the memory recall improvement by ethanol when it replaced morphine on the test day. A review of the literature suggests other possibilities such as the release of intermediate neurotransmitters.

Cited by 25 publications

References 37 publications

Effects of morphine on the plus-maze discriminative avoidance task: role of state-dependent learning

Effects of morphine on the plus-maze discriminative avoidance task: role of state-dependent learning

Influence of Intracerebroventricular Administration of Histaminergic Drugs on Morphine State-Dependent Memory in the Step-Down Passive Avoidance Test

Effects of Clozapine and Sulpiride on Morphine State-Dependent Memory in the Step-Down Passive Avoidance Test

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