Anredera cordifolia (Ten.) v. Steenis

Sukandar, Elin Yulinah; Ayuningtyas, Dhyan Kusuma

doi:10.1201/9781315187853-22

Cited by 4 publications

(9 citation statements)

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“…In the Binahong leaf extract, there is saponin, which can increase the expression of TGF-α (transforming growth factor-alpha) and TGF-β (transforming growth factor-beta). 19 , 45 TGF-β can activate fibroblasts and TGF-α can activate Osterix, which will function in osteoblast differentiation. 19 , 45 Saponin is also antiseptic and it can affect cell membrane integrity and cause the lysis of pathogens, especially fungi.…”

Section: Discussionmentioning

confidence: 99%

“… 19 , 45 TGF-β can activate fibroblasts and TGF-α can activate Osterix, which will function in osteoblast differentiation. 19 , 45 Saponin is also antiseptic and it can affect cell membrane integrity and cause the lysis of pathogens, especially fungi. 46 …”

Section: Discussionmentioning

confidence: 99%

“…However, the characteristics of Binahong, which are its abilities to grow easily and rapidly in varied climates, can also be advantages because Binahong can be used as an alternative medicine that is also highly-sustainable. 19 , 20 Binahong is known to have pharmacological properties, such as antiinflammatory, antibacterial, antifungal, antiviral, and antioxidant properties. 19 , 21 It could also improve kidney function, counter hyperlipidemia, reduce hypertension, become anticancer, act as an analgesic, and help wound healing, including tooth socket wounds.…”

Section: Introductionmentioning

confidence: 99%

“… 19 , 20 Binahong is known to have pharmacological properties, such as antiinflammatory, antibacterial, antifungal, antiviral, and antioxidant properties. 19 , 21 It could also improve kidney function, counter hyperlipidemia, reduce hypertension, become anticancer, act as an analgesic, and help wound healing, including tooth socket wounds. 19 , 21 Binahong also has been used in traditional medicine by placing its leaves over wounds and it has shown an affinity in accelerating wound healing.…”

Section: Introductionmentioning

confidence: 99%

“… 19 , 21 It could also improve kidney function, counter hyperlipidemia, reduce hypertension, become anticancer, act as an analgesic, and help wound healing, including tooth socket wounds. 19 , 21 Binahong also has been used in traditional medicine by placing its leaves over wounds and it has shown an affinity in accelerating wound healing. 21 , 22 This is due to the presence of the secondary metabolites contained in the Binahong leaf extract such as tannins, saponins, flavonoids, alkaloids, anthraquinones, phenolic acids, triterpenes, steroids, and glycosides.…”

Section: Introductionmentioning

confidence: 99%

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Effects of 3% binahong (Anredera cordifolia) leaf extract gel on alveolar bone healing in post-extraction tooth socket wound in Wistar rats (Rattus norvegicus)

Hanafiah

Dohude

et al. 2022

F1000Res

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Background: Binahong (Anredera cordifolia (Ten.) STEENIS) is a widely available herbal plant in Indonesia and has been intensely researched for its healing abilities due to its biological activities, but few have studied its capability in accelerating hard tissue healing in post-extraction tooth sockets. The purpose of this study was to analyse the effects of 3% binahong leaf extract gel on alveolar bone healing in post-extraction sockets in Wistar rats. Methods: In this study, 48 male Wistar rats were randomly allocated to twelve groups. After the extraction of the left mandibular incisor, sockets in Group I to IV were given 3% binahong leaf extract gel, group V to VIII were given a control gel, and group IX to XII were given Gengigel® for 14 days. The residual socket volume (RSV) and fibroblast proliferation were observed on the 3rd, 7th, and 14th day post-extraction, while the osteoblast and osteocyte proliferation were observed on the 7th, 14th, and 28th day post-extraction. The RSV data were analysed using repeated measure ANOVA and one-way ANOVA, while the histopathological data were analysed using one-way ANOVA. Results: The results showed that the binahong group had the lowest RSV and the highest fibroblast proliferation compared to the other groups on the 7th day (p<0.05) and the highest osteoblast and osteocyte proliferation compared to the other groups on the 14th day (p<0.05). Conclusion: The experiment showed that 3% binahong leaf extract gel could accelerate wound closure, which was characterized by a greater decrease in the RSV value in comparison to the other treatment groups and could enhance alveolar bone healing by increasing the proliferation of fibroblasts, osteoblasts, and osteocytes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of 3% binahong (Anredera cordifolia) leaf extract gel on alveolar bone healing in post-extraction tooth socket wound in Wistar rats (Rattus norvegicus)

Hanafiah

Dohude

et al. 2022

F1000Res

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Evaluation of the teratogenic effect of water extract of Sonchus arvensis L. and Anredera cordifolia (Ten.) Steenis leaves as a combination in Wistar rat

SULISKA¹,

MENTARI²,

SUKANDAR³

2023

jrp

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Water extract of Sonchus arvensis and Anredera cordifolia leaves as a combination has been proven for their antihypertensive activity, but there is no information about its safety for pregnant women yet. This experiment aimed to evaluate the teratogenic effect of water extract of S. arvensis and A. cordifolia leaves as a combination (1:1) at doses of 100 mg/kg bw, 400 mg/kg bw, and 1000 mg/kg bw in Wistar rats. The extract was made into suspension in sodium carboxymethyl cellulose (Na-CMC) 0.5% and given orally to pregnant rats on gestation day 6-15 as much as 1 mL/100 gram bw. Pregnant rats were sacrificed at gestation day 19. All parameters related to fetuses included the number of fetuses, fetal weight, skeletal and organ malformation were evaluated. The percentage of skeletal and organ malformation of each treatment groups was compared to the control group and analyzed with one-way ANOVA method using IBM SPSS 28. There was no significant difference in both average number and fetal weight from all treatment groups compared to the control group (P>0.05). Skeletal malformation was not found, but there were undeveloped fetuses (resorption) and some fetuses with small brains in all groups. The percentage of each treatment groups for those two conditions was not significantly different compared to the control group. Therefore, water extract of S. arvensis and A. cordifolia leaves as a combination at doses of 100 mg/kg bw, 400 mg/kg bw, and 1000 mg/kg bw contraindicated for pregnant women and those who are planning on pregnancy.

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The Potential of Binahong Leaves Extract Nanogel for Alveolar Bone Healing

Bernard,

Syafruddin Ilyas,

Olivia Avriyanti Hanafiah

2024

AMCR

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Alveolar bone defects pose a significant challenge in dental and oral health, requiring the exploration of novel therapeutic approaches for effective bone healing. The binahong (Anredera cordifolia) leaves are known for their rich bioactive compounds with diverse therapeutic properties, while nanogels, a drug delivery system, offer advantages such as controlled release and enhanced bioavailability. This review explores the potential of binahong leaf extract nanogel as a promising candidate for alveolar bone healing by discussing its preparation, characterization, and properties. Furthermore, it delves into the cellular and molecular mechanisms underlying alveolar bone healing. Based on our review, the effects of binahong leaves extract on bone cells and animal models indicate its therapeutic potential in alveolar bone healing by increasing the expression of growth factors and cells that are essential in bone healing. This review suggests that binahong leaves extract nanogel holds promise as a novel therapeutic intervention for alveolar bone healing. Further research and clinical studies are warranted to fully explore its potential.

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Anredera cordifolia (Ten.) v. Steenis

Cited by 4 publications

References 0 publications

Effects of 3% binahong (Anredera cordifolia) leaf extract gel on alveolar bone healing in post-extraction tooth socket wound in Wistar rats (Rattus norvegicus)

Effects of 3% binahong (Anredera cordifolia) leaf extract gel on alveolar bone healing in post-extraction tooth socket wound in Wistar rats (Rattus norvegicus)

Evaluation of the teratogenic effect of water extract of Sonchus arvensis L. and Anredera cordifolia (Ten.) Steenis leaves as a combination in Wistar rat

The Potential of Binahong Leaves Extract Nanogel for Alveolar Bone Healing

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