Anogenital warts in childhood

Hanson, Ralph; Glasson, M. J.; McCrossin, Ian; Rogers, Maeve; Rose, Barbara; Thompson, Catherine C.

doi:10.1016/0145-2134(89)90009-4

Cited by 61 publications

(23 citation statements)

References 31 publications

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“…2 biyopsi materyalinde HPV 2 + iken, 2 tanesinde ise hem HPV 2, hem de HPV 18 izlendi. Araştırmacılar cinsel istismar tanısının klinik değerlendirme-den ziyade hikaye ile belirlenmesi gerektiğini, çünkü sadece 2 çocuğun cinsel istismarın fizik muayene bulgularına sahip olduğunu belirtmişlerdir [18].…”

Section: Discussionunclassified

Anogenital Warts in Children and Sexual Abuse

Karateke¹

2014

Ann Clin Anal Med

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ÖzetAmaç: Bu çalışmanın amacı anogenital siğili (AGS) olan çocukların anneleri ile beraber Human Papilloma Virus (HPV) genotiplemesi yapılarak cinsel istismarı belirlemektir. Gereç ve Yöntem: Çalışmaya AGS'si olan 10 çocuk, anneleri ile beraber dâhil edildi. Çocuklarda ve annelerde HPV tiplemesi yapıldı. Ayrıca anneden 'smear' örneği alındı. Cinsel istismar düşünülen 4 çocuğa cinsel istismar testi (CSA) testi uygulandı. Bulgular: AGS'si bulunan 10 çocuğun annelerinden birinde AGS saptandı. HPV tiplemesi 4 çocukta pozitif bulunurken, bu çocukların annelerinin 3'ünde HPV tiplemesi uyumlu saptandı. Bu HPV genotiplerinin 2'si tip 6, diğeri ise tip 11 idi. Bu dört çocukta cinsel istismar 2'sinde "kesin", birinde "kuvvetle muhtemel" olarak saptanırken, diğerinde ise "mümkün" olarak tespit edildi. Tartışma: AGS'si olan ve cinsel istismar düşü-nülen çocuklarda ebeveynlerin, özellikle annenin HPV tiplemesi yapılarak cinsel istismar tanısı kolaylaşabilir. Bu değerlendirmeleri yaparken profesyonel ekiple çalışılmalı, istismar düşünülen vakalarda çocuğun daha fazla zarar gör-mesi engellenmeye çalışılmalıdır. Öte yandan anogenital siğillerin farklı bulaş yolları da olabileceğinden, tam değerlendirme yapmadan suçsuz bir aileyi zan altında bırakabilecek davranışlardan kaçınılmalıdır. Anahtar KelimelerAnogenital Siğil; Cinsel İstismar; Çocuk Abstract Aim: The aim of this study was to determine the sexual abuse in children with anogenital warts (AGW) together with their mothers by testing Human Papilloma Virus (HPV) typing. Material and Method: A total of 10 children with their mothers were included. HPV typing was performed in children and their mothers. Smear sample was taken from mothers. Child sexual abuse test was performed for 4 children in whom sexual abuse was suspected. Results: AGW was found in one of the mothers of 10 children with AGW. While HPV typing was positive in 4 children, 3 mothers was detected as "compatible" with HPV typing of their children. Two of those were type 6 and the remaining was type 11. While sexual abuse was identified to be "definite" in 2 children and "probable" in 1 child. Other was identified as "possible". Discussion: The diagnosis of sexual abuse in children with AGW and suspected sexual abuse can be facilitated by performing HPV typing in mothers of children. This requires professional teamwork to prevent any possible harm against the potential child victim of suspected sexual abuse. As other transmission routes of AGW are possible, accusing falsely innocent family before comprehensive examination should be avoided.

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Section: Discussionunclassified

Anogenital Warts in Children and Sexual Abuse

Karateke¹

2014

Ann Clin Anal Med

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“…During the second half of the 1980s, a clear picture of the presence of specific types of HPV in genital warts in children was obtained (21,22,24). These initial reports enthusiastically supported HPV typing as an important prognostic tool for HPV-infected children, particularly in those infected with HPV 16 and HPV 18, due to the highly oncogenic potential of these two HPV types (24).…”

Section: Hpv In Children: a Brief Overviewmentioning

confidence: 99%

“…These initial reports enthusiastically supported HPV typing as an important prognostic tool for HPV-infected children, particularly in those infected with HPV 16 and HPV 18, due to the highly oncogenic potential of these two HPV types (24). For this reason, at that time, several paediatric departments were requesting HPV typing in cases with genital warts in order to identify children who were at a risk of developing cancer.…”

Section: Hpv In Children: a Brief Overviewmentioning

confidence: 99%

“…At the same time, researchers evaluated the impact of the presence of HPV in the diagnosis of sexual abuse. However, early enough, it was made clear that HPV typing using molecular techniques is not sufficient to determine the source of HPV infection and pursue the possibility of sexual abuse (24,26,27). In the study by Padel et al (27), it was well established that HPV typing does not provide substantial evidence of the presence or absence of sexual transmission.…”

Section: Hpv In Children: a Brief Overviewmentioning

confidence: 99%

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The paediatric story of human papillomavirus (Review)

2014

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Human papillomavirus (HPV) is composed of a particularly heterogeneous family of DNA viruses, which has gained much attention in recent years due to the discoveries of Professor Harald zur Hausen, who first identified a connection between HPV and cervical cancer. Professor Harald zur Hausen, the ‘Father of HPV Virology’, was the recipient of the 2008 Nobel Prize. HPV can be transmitted through physical contact via autoinoculation or fomites, sexual contact, as well as vertically from the HPV-positive mother to her newborn, causing subclinical or clinical infections. In infancy and childhood, HPV-associated clinical infections include skin warts, genital warts and juvenile recurrent respiratory papillomatosis, while cervical squamous intraepithelial lesions have also been reported among adolescent girls. To date, several research teams, worldwide, have extensively investigated HPV from the paediatric point of view. This primitive effort has been performed before the recent great expansion of paediatric HPV research due to the vaccination programmes against HPV, which were introduced into clinical practice in 2006. In this review article, we present a brief overview of paediatric HPV research after the first report in 1978 involving children in the research of HPV until the time point of this great expansion. In the future, it is expected that further unresolved issues will be addressed and clarified, as the paediatric story of HPV remains a challenging research target.

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“…Perinatally transmitted infection has a long latency period, at times reaching 2 years. Most infections in children over 2 years of age are probably associated with sexual contact (Hanson, Glasson, McCrossin, & Rogers, 1989).…”

Section: Condylomata Accuminata (Genital Warts)mentioning

confidence: 99%