Anodic oxidation and hydrothermal treatment of titanium results in a surface that causes increased attachment and altered cytoskeletal morphology of rat bone marrow stromal cells
            <i>in vitro</i>

Takebe, Jun; Itoh, Sozo; Okada, Jiro; Ishibashi, Kanji

doi:10.1002/1097-4636(20000905)51:3<398::aid-jbm14>3.0.co;2-#

Cited by 140 publications

(94 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Okumura et al (2001) suggest that the lack of vinculin-containing adhesion sites in the osteoblasts on HA is because they are of a more differentiated phenotype. The differential phenotype theory is also cited in other studies (Schwartz and Boyan, 1994;Takebe et al, 2000). The results from this study, however, indicated that this might not have been the case.…”

Section: C Baxter Et Al Fibroblast and Osteoblast Adhesionmentioning

confidence: 44%

“…HA is thought to be biocompatible surface coating that can accelerate properties of bone healing (Chou et al, 1999). Takebe et al (2000) show that cells on HA have a flattened spreading morphology with numerous filopodia and that they are intimately associated with the surface, but that cell adhesion is greater on commercially pure titanium at 60 and 120 minutes after introduction. Okumura et al (2001) also demonstrate that fewer vinculin containing adhesion plaques are present in osteoblasts on HA at 12 and 24 hours, when compared to titanium.…”

Section: C Baxter Et Al Fibroblast and Osteoblast Adhesionmentioning

confidence: 99%

See 1 more Smart Citation

Fibroblast and osteoblast adhesion and morphology on calcium phosphate surfaces

Baxter

Frauchiger²,

Textor³

et al. 2002

eCM

113

View full text Add to dashboard Cite

Implant loosening in bone fixation is an unresolved complication associated with internal fixation. It is generally accepted that this problem can be overcome by modifying the implant/bone interface for improved osseointegration. This is achieved, in part, by hydroxyapatite (HA) or tricalcium phosphate coatings. Unfortunately, the benefits of these coatings are constrained by not only the generally low strength of their adhesion to the implant surface but also the limited cohesion within their layers. Anodic Plasmachemical treatment (APC) has been developed to incorporate electrolytes and produce coatings with various microtopographies and strong adhesion to implants. In this in vitro study fibroblast and osteoblast morphologies and adhesion to various substrates were evaluated using qualitative and quantitative methods. The substrates were Thermanox plastic and commercially pure titanium. The latter were surface-treated using several different methods: conventional anodisation, plasma spraying of HA and anodic plasma-chemical (APC) treatment in an electrolyte solution containing either calcium and phosphate (APCCaP) or phosphoric acid (APC-P). Both osteoblasts and fibroblasts showed extensive cell spreading, total cell area and greatest amount of adhesion, with defined adhesion patterns on the Thermanox plastic, anodised titanium, and the two APC-CaP substrates. With fibroblasts, almost no cell spreading and very low adhesion, was observed in cells cultured on the APC-P and HA surfaces. The extent of cell spreading correlated with the area of focal adhesions as assessed by the amount of vinculin labelling. The Thermanox plastic, anodised titanium, and the two APCCaP substrates were the most cytocompatible substrates with regard to this in vitro evaluation.

show abstract

Section: C Baxter Et Al Fibroblast and Osteoblast Adhesionmentioning

confidence: 44%

Section: C Baxter Et Al Fibroblast and Osteoblast Adhesionmentioning

confidence: 99%

Fibroblast and osteoblast adhesion and morphology on calcium phosphate surfaces

Baxter

Frauchiger²,

Textor³

et al. 2002

eCM

113

View full text Add to dashboard Cite

show abstract

“…MAO can make titanium implant surface bioactive, porous, and nanocrystallized. Takebe et al [152] reported that the thin HA layer formed by anodization and hydrothermal treatment on the surface of cpTi implant materials showed desirable cellular behavior. The thin HA layer on the 76 X cpTi surface affects cellular attachment and spreading, and a thin HA layer appears to be more osteoconductive to cellular attachment than untreated cpTi as illustrated in Fig.…”

Section: Anodic Oxidationmentioning

confidence: 99%

Surface modification of titanium, titanium alloys, and related materials for biomedical applications

Liu

Chu

Ding

2004

Materials Science and Engineering: R: Reports

3,032

1,477

View full text Add to dashboard Cite

Titanium and titanium alloys are widely used in biomedical devices and components, especially as hard tissue replacements as well as in cardiac and cardiovascular applications, because of their desirable properties, such as relatively low modulus, good fatigue strength, formability, machinability, corrosion resistance, and biocompatibility. However, titanium and its alloys cannot meet all of the clinical requirements. Therefore, in order to improve the biological, chemical, and mechanical properties, surface modification is often performed. This article reviews the various surface modification technologies pertaining to titanium and titanium alloys including mechanical treatment, thermal spraying, sol-gel, chemical and electrochemical treatment, and ion implantation from the perspective of biomedical engineering. Recent work has shown that the wear resistance, corrosion resistance, and biological properties of titanium and titanium alloys can be improved selectively using the appropriate surface treatment techniques while the desirable bulk attributes of the materials are retained. The proper surface treatment expands the use of titanium and titanium alloys in the biomedical fields. Some of the recent applications are also discussed in this paper. #

show abstract

“…A group of researchers reported that desirable cellular behaviour such as cell growth, cell attachment, etc. can be obtained from the thin HA layer on the surface of CP-Ti which was produced by anodization and subsequently followed by hydrothermal treatment (Takebe et al, 2000). It is observed that cellular attachment and spreading are affected by this thin HA layer on the CP-Ti surface.…”

Section: Anodic Oxidationmentioning

confidence: 99%