Annulative π-extension of 1-phenylsulfonyl-2/3-bromomethylindole via Zn(OTf)₂-mediated domino reaction with thiophene analogs

Recent synthetic strategies for the construction of functionalized carbazoles and their heterocyclic motifs enabled by Lewis acids

“…This reaction condition led to the production of highly complex heterocyclic compounds, 3 in high yields as cited in Scheme 11. 104 In 2021 Mohanakrishnan and his group reported the synthesis of annulated carbazole 8a 69% by reacting bromomethylindole with veratrole by using 20 mol% FeCl 3 as Lewis acid. They further studied substrate scope by having the best conditions in their hand.…”

“…This reaction condition led to the production of highly complex heterocyclic compounds, 3 in high yields as cited in Scheme 11 . 104 …”