Angiotensinogen Gene M235T and T174M Polymorphisms and Susceptibility of Pre‐Eclampsia: A Meta‐Analysis

Abstract

SummaryThere are controversies in reports on the association of the angiotensinogen (AGT ) gene polymorphisms with the risk of developing pre-eclampsia (PE). We performed a meta-analysis to examine the association between the AGT polymorphisms and PE risk: M235T (31 studies involving 2555 patients and 6114 controls) and T174M (six studies involving 681 patients and 2076 controls). For the M235T polymorphism, the TT genotype increased the PE risk as compared to the MM genotype (odds ratio 1.61, 95% confidence intervals 1.22-2.14, P = 0.001). When stratified by ethnicity, the TT genotype remained significantly associated with higher PE risk in Caucasians and Mongolians but not in Africans. Similar results were also obtained under all three genetic models of the M235T polymorphism. For the T174M polymorphism, no significant association was found in the comparisons (MT vs. TT and MM vs. TT) and under any genetic models. The analysis excluding the highly significant Hardy-Weinberg equilibrium-violating studies and sensitivity analysis further strengthened the validity of these associations. No publication bias was observed in this study. This meta-analysis demonstrates that the AGT M235T polymorphism is significantly associated with PE whereas the T174M polymorphism is not.

Role of ACE and AGT gene polymorphisms in genetic susceptibility to diabetes mellitus type 2 in a Brazilian sample

“…Our findings are in agreement with prior studies that have found an association between this polymorphism and DM2 (Young et al, 1998;Mehri et al, 2010). Additionally, meta-analyses have also reported associations between the A allele of the polymorphism and the risk of cardiovascular diseases Pan, 2012, 2013;Liang et al, 2013a,b;Li et al, 2013;Chen et al, 2014), renal failure (Zhou et al, 2013b), pre-eclampsia (Lin et al, 2012), and breast cancer (Xi et al, 2011). However, a meta-analysis involving Caucasian and Asian individuals failed to detect an association between the rs699 polymorphism and diabetic nephropathy (Ding et al, 2012).…”

Polymorphisms in renin-angiotensin-aldosterone system and vascular endothelial growth factor may cross talk in preeclampsia: a pilot study of maternal and fetal dyads in Indian population

“…Previously AGT gene polymorphisms (Met235Thr (rs699) and Thr174Met (rs4762)) have been reported to be associated with severe preeclampsia. 21,22 Although the same polymorphisms have not been associated here, AGT polymorphisms play a significant role in the severity of the disease. Allele frequency of each SNP was also analyzed in fetuses of mild and severe PE and a number of variations of ACE, GNB3, ESR2 and SCNN1Bshowed significant differences between the two groups.…”

Predictive Value of Free β-hCG Multiple of the Median for Women with Preeclampsia

“…After reading the abstract for relevance, full-text papers were assessed for their suitability according to the following inclusion criteria: (1) relationship between β-hCG MoM and PE; (2) case-control design; (3) diagnosis of PE confirmed by the applicable provision of new-onset hypertension (≥140/90 mm Hg) in pregnant women who were normotensive before 20 weeks of gestation and proteinuria [≥300 mg protein in a 24-h urine collection, which usually correlates with ≥30 mg/dl (≥1 + reading on dipstick) in a random urine determination with no evidence of urinary tract infection] [20]; (4) original data must be provided. The exclusion criteria were abstracts, editorials, narrative reviews, case reports, letters to the editor, meta-analyses or other types of articles that did not involve primary study results.…”