Polymorphisms in renin-angiotensin-aldosterone system and vascular endothelial growth factor may cross talk in preeclampsia: a pilot study of maternal and fetal dyads in Indian population

Sharma, Sangeeta; Bhaskaran, Sruthi; Tripathi, Shashi Bhushan; Vaid, Neelam; Varma, Binuja

doi:10.18203/2320-6012.ijrms20161246

Cited by 2 publications

(3 citation statements)

References 11 publications

(12 reference statements)

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“…In a study conducted in Chile, no association between PE and variants of the REN gene in offspring was reported [ 85 ]. In contrast, a strong correlation between REN ( rs 11240688) and AGT ( rs 11122576 G>A) foetal polymorphism and PE development was noted in a North Indian population study [ 86 ]. This observation indicates a strong association between foetal genotypes of REN and AGT that give rise to the stimulation of maternal RAAS and the disruption of angiogenesis, thereby triggering maternal PE.…”

Section: Genetic Appraisal Of Raasmentioning

confidence: 99%

“…Contrary to this finding, the GOPEC study revealed no association between PE and haplotypes of maternal AGT when investigating the relationship between 536 foetal triads (mother-father-child) and 398 maternal triads (grandmother-grandfather-mother) of British descent [ 107 ]. The variations of AGT ( rs7079 ) revealed staggering differences when evaluating PE prevalence, particularly the severe form and is, therefore comparable to the mild form of PE [ 86 ]. South Africans of African ancestry have salt-sensitive hypertension [ 111 ] and thus could be less accommodating to RAAS inhibitors [ 20 ••].…”

Section: Genetic Appraisal Of Raasmentioning

confidence: 99%

“…A greater distribution of AGT (MT) genotype compared to preeclamptic HIV-infected women African ancestry in South Africa [ 95 ••] AGT ( rs 7079) Polymorphisms in renin-angiotensin-aldosterone system and vascular endothelial growth factor may crosstalk in preeclampsia: a pilot study of maternal and foetal dyads in Indian population. The AGT (rs7079) polymorphism revealed a significant difference when assessing the prevalence of severe PE North India (Indo European origin) [ 86 ] ACE ( rs 4305) Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals. Directly proportional relationship between the ACE rs 4305 polymorphism and hypertension European ancestry [ 128 ] ACE ( rs 4343) The gene variants of maternal/fetal renin-angiotensin system in preeclampsia: a hybrid case-parent/mother-control study.…”

Section: Genetic Appraisal Of Raasmentioning

confidence: 99%

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Genetic Appraisal of RAAS-Associated SNPs: REN (rs16853055), AGT (rs3789678) and ACE (rs4305) in Preeclamptic Women Living with HIV Infection

Govindsamy,

Singh,

Naicker

2024

Curr Hypertens Rep

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Purpose of Review The primary goal of this review article was to determine whether the three RAAS-associated SNPs, Renin-rs16853055, AGT-rs3789678 and ACE-rs4305 are genetically linked to the development of hypertension in preeclampsia. The secondary goal was to establish if there was a link between these SNPs and HIV infection. Recent Findings There is a paucity of findings related to the aforementioned SNPs and preeclampsia. There are no recent findings on the rs16853055 renin polymorphism. The rs3789678 angiotensinogen polymorphism correlated significantly with gestational hypertension. The rs4305 ACE polymorphism showed no significant association with the development of pregnancy-induced hypertension. Summary There are conflicting findings when determining the relationship between ethnicity and the predisposition of preeclampsia and hypertension in relation to the discussed RAAS-associated SNPs. To date, the association between RAAS-associated SNPs and preeclamptic women co-morbid with HIV in South Africa has revealed that certain alleles of the AGT gene are more prominent in HIV-infected PE compared to normotensive pregnant HIV-infected women.

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Section: Genetic Appraisal Of Raasmentioning

confidence: 99%

Section: Genetic Appraisal Of Raasmentioning

confidence: 99%