Angiotensin-converting enzymes (ACE and ACE2) are downregulated in renal tumors

Larrinaga, Gorka; Perez, Itxaro; Sanz, Begoña; Blanco, Lorena; López, José I.; Candenas, M. Luz; Pinto, Francisco M.; Gil, Javier; Irazusta, Jon; Varona, Amparo

doi:10.1016/j.regpep.2010.07.170

Cited by 24 publications

(33 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similarly to our own observations, Larrinaga et al indicated the special role of intrarenal RAS (iRAS) in renal cancer. In this study, the activity and immunoreactivity of both ACE and ACE2 was downregulated in renal cancer cells, as compared with adjacent normal kidney tissue [37]. The authors speculated about the possibility of using these enzymes as prognostic and diagnostic factors, although this hypothesis remains to be clarified [37].…”

Section: Discussionmentioning

confidence: 71%

“…In this study, the activity and immunoreactivity of both ACE and ACE2 was downregulated in renal cancer cells, as compared with adjacent normal kidney tissue [37]. The authors speculated about the possibility of using these enzymes as prognostic and diagnostic factors, although this hypothesis remains to be clarified [37]. The role of RAS in cancer pathogenesis has also been supported by the study of Dolley-Hitze et al, which was performed on renal clear-cell cancer and recognized the expression of AT1R and AT2R as negative prognostic and predictive factors [38].…”

Section: Discussionmentioning

confidence: 72%

See 1 more Smart Citation

ACE and ACE2 expression in normal and malignant skin lesions

Grzegrzółka

Swiatko

Puła

et al. 2013

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

Abstract:The renin-angiotensin system (RAS) is known mainly as a regulator of cardiovascular homeostasis. However, it has also been shown to mediate processes such as proliferation, apoptosis, angiogenesis, and carcinogenesis. Nonmelanoma skin cancers (NMSC) -including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) -are among the most common cancers. The aim of the present study was to determine the immunohistochemical expression of angiotensin-converting enzyme (ACE), angiotensin-converting enzyme 2 (ACE2), and Ki-67 antigen in archival samples of normal skin, actinic keratosis, and malignant skin lesions. Cytoplasmic-nuclear ACE immunoreactivity was observed in 99% of examined cases of both normal skin and cancers. Significantly higher ACE immunoreactivity occurred in normal skin, as compared with BCC and SCC (p < 0.01, p < 0.0001, respectively). Additionally, ACE immunoreactivity was also significantly higher in BCC, compared with SCC (p < 0.05). ACE2 immunoreactivity was noted in basal epidermal layers and in sebaceous gland cells in normal skin, though not in NMSC. These novel observations suggest that ACE and skin RAS may be involved in the pathogenesis of malignant skin lesions.

show abstract

Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 72%

ACE and ACE2 expression in normal and malignant skin lesions

Grzegrzółka

Swiatko

Puła

et al. 2013

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

show abstract

“…Our previous studies (4, 5, 27-29, 58, 59) have demonstrated that the activity, protein expression, and mRNA levels of these three and other peptidases are selectively altered in several subtypes of renal cell neoplasms (CCRCC, papillary renal cell carcinoma, chromophobe renal cell carcinoma, and renal oncocytoma). What is more, we have found that several peptidase activities are significantly increased in high-stage and high-grade CCRCC, suggesting the involvement of these enzymes in the biological aggressiveness of these neoplasms (4,27,29,59).…”

mentioning

confidence: 77%

The impact of peptidase activity on clear cell renal cell carcinoma survival

Larrinaga

Blanco

Sanz

et al. 2012

American Journal of Physiology-Renal Physiology

Self Cite

View full text Add to dashboard Cite

Several studies have proposed that protease expression and activity may have a predictive value in the survival of clear cell renal cell carcinoma (CCRCC). Most efforts on this issue have been focused on the analysis of matrix metalloproteinases (MMP) and very little on the role of other proteases, such as peptidases. The catalytic activity of 9 peptidases (APN, APB, ASP, CAP, DPP-IV, NEP/CD10, PEP, PGI, and PSA) was quantified by fluorometric methods in a series of 79 CCRCC patients, and the results obtained were analyzed for survival (Kaplan-Meier curves, log-rank test, and Cox multivariate analysis). CCRCC patients with higher activity levels of membrane-bound APN and soluble APN, DPP-IV, and CAP had significantly shorter 5-yr survival rates than those with lower levels. By contrast, higher soluble APB activity significantly correlated with longer survival. Our data suggest the involvement of peptidases in the biological aggressiveness of CCRCC and support the usefulness of measuring these proteases to assess the prognosis of patients with CCRCC.

show abstract

“…Therefore, these divergent results imply that the enzyme may be differently regulated in the two conditions and as a function of gender. In addition, it has also been demonstrated gender related differences in angiotensin-converting peptidase activities and proposed this phenomenon as one of the factors which could influence cardiovascular disorders [30]. Indeed, several studies have identified gender differences in diseases of the tonsils [31,32].…”

Section: Discussionmentioning

confidence: 99%