Activity of soluble aminopeptidase A and dipeptidyl peptidase IV and membrane-bound aminopeptidase B and pyroglutamyl peptidase I in adenoid hyperplasia, tonsillar hyperplasia and chronic tonsillitis

Larrinaga, Gorka; Perez, Itxaro; Sanz, Begoña; Irazusta, Amaia; Zarrazquin, Idoia; Sanchez, Carmen Elena; Rey, Ana Sánchez del; Zabala, Aitor; Santaolalla, Francisco

doi:10.1016/j.ijporl.2011.07.037

Cited by 5 publications

(3 citation statements)

References 36 publications

(50 reference statements)

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“…3C – E ). Aminopeptidase B and endopeptidase-24.11 (metalloendopeptidase/neprilysin) are membrane bound enzymes ( Larrinaga et al, 2011 ; Mumford et al, 1981 ). The localization of these peptidases to specific neural and cellular compartments is not broadly established.…”

Section: Peptide Release and Volume Of Influencementioning

confidence: 99%

The life and times of endogenous opioid peptides: Updated understanding of synthesis, spatiotemporal dynamics, and the clinical impact in alcohol use disorder

et al. 2023

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Section: Peptide Release and Volume Of Influencementioning

confidence: 99%

The life and times of endogenous opioid peptides: Updated understanding of synthesis, spatiotemporal dynamics, and the clinical impact in alcohol use disorder

et al. 2023

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“…Abnormal peptidase levels have been observed in a range of conditions, from renal cancer (ACE and NAP) 23 to chronic tonsillitis (APA and dipeptidyl-peptidase IV). 24 In OA, proteomic studies have shown inflammatory cytokines and proteases in synovial fluid, 25 , 26 and evidence suggests the renin-angiotensin system may play a role in the pathophysiology of arthritis. 13 , 27 Specifically, dipeptidyl-peptidase IV could be involved in OA inflammation.…”

Section: Introductionmentioning

confidence: 99%

Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression

Calvo

Sánchez-Herraéz

Casis

et al. 2020

Bone & Joint Research

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Aims To analyze the potential role of synovial fluid peptidase activity as a measure of disease burden and predictive biomarker of progression in knee osteoarthritis (KOA). Methods A cross-sectional study of 39 patients (women 71.8%, men 28.2%; mean age of 72.03 years (SD 1.15) with advanced KOA (Ahlbäck grade ≥ 3 and clinical indications for arthrocentesis) recruited through the (Orthopaedic Department at the Complejo Asistencial Universitario de León, Spain (CAULE)), measuring synovial fluid levels of puromycin-sensitive aminopeptidase (PSA), neutral aminopeptidase (NAP), aminopeptidase B (APB), prolyl endopeptidase (PEP), aspartate aminopeptidase (ASP), glutamyl aminopeptidase (GLU) and pyroglutamyl aminopeptidase (PGAP). Results Synovial fluid peptidase activity varied significantly as a function of clinical signs, with differences in levels of PEP (p = 0.020), ASP (p < 0.001), and PGAP (p = 0. 003) associated with knee locking, PEP (p = 0.006), ASP (p = 0.001), GLU (p = 0.037), and PGAP (p = 0.000) with knee failure, and PEP (p = 0.006), ASP (p = 0.001), GLU (p = 0.037), and PGAP (p < 0.001) with knee effusion. Further, patients with the greatest functional impairment had significantly higher levels of APB (p = 0.005), PEP (p = 0.005), ASP (p = 0.006), GLU (p = 0.020), and PGAP (p < 0.001) activity, though not of NAP or PSA, indicating local alterations in the renin-angiotensin system. A binary logistic regression model showed that PSA was protective (p = 0.005; Exp (B) 0.949), whereas PEP (p = 0.005) and GLU were risk factors (p = 0.012). Conclusion These results suggest synovial fluid peptidase activity could play a role as a measure of disease burden and predictive biomarker of progression in KOA. Cite this article: Bone Joint Res 2020;9(11):789–797.

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“…1,[4][5][6] In fact, the use of certain peptidases as tumor markers is widely described. [7][8][9][10][11][12][13] On the other hand, some peptidases inhibitors are currently used in pharmacological therapy. For example, captopril, enalapril, and lisinopril, are inhibitors of angiotensin converting enzyme (ACE), and are used in the treatment of cardiovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

The role of peptidases in (in) fertility

Romeu

Irazusta

Casis

2018

MOJAP

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Activity of soluble aminopeptidase A and dipeptidyl peptidase IV and membrane-bound aminopeptidase B and pyroglutamyl peptidase I in adenoid hyperplasia, tonsillar hyperplasia and chronic tonsillitis

Cited by 5 publications

References 36 publications

The life and times of endogenous opioid peptides: Updated understanding of synthesis, spatiotemporal dynamics, and the clinical impact in alcohol use disorder

The life and times of endogenous opioid peptides: Updated understanding of synthesis, spatiotemporal dynamics, and the clinical impact in alcohol use disorder

Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression

The role of peptidases in (in) fertility

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