Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers for adults with early (stage 1 to 3) non-diabetic chronic kidney disease

Sharma, Pawana; Blackburn, Rachel C; Parke, Claire L; McCullough, Keith; Marks, Angharad; Black, Corri

doi:10.1002/14651858.cd007751.pub2

Cited by 67 publications

(59 citation statements)

References 101 publications

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“…One systemic review. [20] showed that ACE inhibitors or ARBS are very fruitful in CKD grade 1-3 patients, which reduces the ESRD risk. Though most of the patients in our study are CKD stage 5, so prescribing ACE inhibitors and ARBs seems illogical.…”

Section: : Analysis Of Prescriptionsmentioning

confidence: 99%

Antihypertensive Drug Utilisation Pattern Among Chronic Kidney Disease Patients Undergoing Maintenance Dialysis in a Tertiary Care Teaching Hospital

P¹,

Panda²,

Mohapatra³

et al. 2016

jemds

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BACKGROUNDThe world is facing a global epidemic of Chronic Kidney Disease (CKD), a major threat to health in general because of an increasing incidence, high cost of treatment and poor outcome associated with various adverse events and comorbidities. Although improved control of hypertension is known to attenuate progression of Chronic Kidney Disease (CKD), a little is known about the adequacy of treatment of hypertension in patients with CKD in India.

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Section: : Analysis Of Prescriptionsmentioning

confidence: 99%

Antihypertensive Drug Utilisation Pattern Among Chronic Kidney Disease Patients Undergoing Maintenance Dialysis in a Tertiary Care Teaching Hospital

P¹,

Panda²,

Mohapatra³

et al. 2016

jemds

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show abstract

“…Lisinopril is a commonly prescribed ACE inhibitor and this type of medication is commonly used to decrease blood pressure by the renin-angiotensin-aldosteron system [9,10] . These inhibitors block the conversion of angiotensin I to angiotensin II, which ultimately leads to the reduction of blood pressure [11] . Other enzymes besides that which converts angiotensin I to II may also be inhibited.…”

Section: Introductionmentioning

confidence: 99%

Research on garlic capsule and selenium-vitamin A, vitamin B, vitamin C applied in therapy of acute hepatocellular damage in a rat model

Akintunde

Bolarin

2015

Journal of Acute Disease

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A B S T R A C TObjectives: To evaluate the toxicity of lisinopril in liver of male rats and its reversal effect of garlic capsule (GAR) and selenium-vitamin A, vitamin B, vitamin C (SACE). Methods: Thirty five adult male wistar rats were randomly assigned into 5 groups of 7 animals per group. Group I serves as the control, animals in Groups II, III, IV and V received 28 mg/kg body weight of lisinopril via oral route. Group III was co-treated with GAR at therapeutic dose of 250 mg/kg body weight per day. Group IV was co-treated with SACE at dose of 500 mg/kg body weight. Lastly, group V was co-treated with GAR and SACE at doses of 250 and 500 mg/kg body weight respectively, and the experiment last for 8 days.Results: Administration of lisinopril caused systemic toxicity in liver as well as adverse histopathologic changes in the tested tissue. While GAR and SACE significantly (P < 0.05) reversed the toxic effects induced by lisinopril. Conclusions: Collectively, the results suggest that therapeutic dose of lisinopril elicits toxicity in male rats through induction of oxidative damage and depletion of cellular adenosine triphosphate. The reversal effects of GAR and SACE during lisinopril treatment suggest that these antioxidants may find clinical application in cellular damage involving ROS and adenosine triphosphate.

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“…Even the most efficacious class of drugs like ACE-Is/ARBs have failed to show significant nephroprotective effect in nondiabetic chronic kidney disease patients. 15 Hence the insignificant difference between carvedilol and ACEIs/ARBs with placebo observed in our study perhaps can be attributed to the cause of renal failure.…”

Section: Discussionmentioning

confidence: 50%

“…15 One of the outstanding features seen only with ACE-Is/ARBs as nephroprotective agent is their ability to prevent onset of nephropathy. 15 However these drugs need to be used at low doses in patients with chronic kidney disease with raised serum creatinine level and have risk of hyperkelemia. 16 Hence the need for an add-on drug with no added risk of hyperkelemia is needed under such circumstances.…”

Section: Discussionmentioning

confidence: 99%

Carvedilol as nephroprotective agent: a meta-analysis of randomized controlled trials

Hiremath

Lokikere

2016

Int J Basic Clin Pharmacol

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Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers for adults with early (stage 1 to 3) non-diabetic chronic kidney disease

Cited by 67 publications

References 101 publications

Antihypertensive Drug Utilisation Pattern Among Chronic Kidney Disease Patients Undergoing Maintenance Dialysis in a Tertiary Care Teaching Hospital

Antihypertensive Drug Utilisation Pattern Among Chronic Kidney Disease Patients Undergoing Maintenance Dialysis in a Tertiary Care Teaching Hospital

Research on garlic capsule and selenium-vitamin A, vitamin B, vitamin C applied in therapy of acute hepatocellular damage in a rat model

Carvedilol as nephroprotective agent: a meta-analysis of randomized controlled trials

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