Angiotensin converting enzyme inhibitor captopril modifies conditioned place preference induced by morphine and morphine withdrawal signs in rats

Alaei, Hojjatallah; Hosseini, M

doi:10.1016/j.pathophys.2007.01.002

Cited by 12 publications

(8 citation statements)

References 40 publications

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“…In the first step of the experiments, we confirmed the results of other authors (Alaei and Hosseini 2007 ; Sahraei et al 2007 ; Shippenberg et al 2009 ). showing that morphine, given at a dose of 5.0 mg/kg and in a 3-day schedule, produced its rewarding effect, as expected.…”

Section: Discussionsupporting

confidence: 91%

Effects of the adenosinergic system on the expression and acquisition of sensitization to conditioned place preference in morphine-conditioned rats

Listos

Talarek

Listos³

et al. 2015

Naunyn-Schmiedeberg's Arch Pharmacol

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In the presented study, we attempt to investigate if the sensitization to conditioned place preference (CPP) induced by low doses of morphine was developed in rats which have been previously conditioned with morphine. The experiments were performed in the CPP test. Firstly, it has been demonstrated that administration of ineffective dose of morphine on the 9th day induces the increase in time spent of rats at a morphine-paired compartment, confirming that sensitization to CPP has been developed in these animals. Secondly, it has been shown that stimulation of A1 receptor significantly inhibits the expression of morphine-induced of sensitization, and blockade of these receptors produces the opposite effect. Finally, it has been indicated that both stimulation and blockade of A1 and/or A2A receptors inhibit the acquisition of sensitization to CPP. The obtained results have strongly supported the significance of adenosinergic system in both expression and acquisition of studied sensitization. These results seem to be important for the identification of connections in the central nervous system which can help finding new strategies to attenuate rewarding action of morphine.

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Section: Discussionsupporting

confidence: 91%

Effects of the adenosinergic system on the expression and acquisition of sensitization to conditioned place preference in morphine-conditioned rats

Listos

Talarek

Listos³

et al. 2015

Naunyn-Schmiedeberg's Arch Pharmacol

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show abstract

“…The result of present study may be due to each of these neurotransmitters. However, the dopaminergic mesolimbic system that consist of ventral tegmental area (VTA), nucleus accumbens and medial prefrontal cortex is considered to be crucial in the rewarding actions of opiates and involved in drug dependence [30]. Chen et al [18] have shown that 12 weeks of exercise intervention abolishes acute MDMA-stimulated dopamine release in nucleus accumbens and also rewarding efficacy of this drug.…”

Section: Discussionmentioning

confidence: 99%

Treadmill exercise reduces self-administration of morphine in male rats

et al. 2009

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“…Sterotaxic coordinates were selected according to the rat brain atlas of Paxinos and Watson (0.9 mm posterior to the bregma, lateral + 1.6 mm lateral to the sagittal suture, and 3 mm from the top of skull). [ 36 37 ] The cannulas were fixed with dental acrylic cement and anchored by two screws placed in the skull. A stylet (26-gauge stainless steel) was placed into the guide cannula to allow the guide cannula to maintain patency.…”

Section: Methodsmentioning

confidence: 99%

“…A stylet (26-gauge stainless steel) was placed into the guide cannula to allow the guide cannula to maintain patency. [ 36 37 ]…”

Section: Methodsmentioning

confidence: 99%

Interaction of central Angiotensin II and estrogen on systolic blood pressure in female DOCA-salt treated rats

et al. 2016

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Background:There is a probable interaction of central angiotensin II (Ang II) and estrogen (Est) on blood pressure in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Therefore, in the present study, the interaction between Ang II and Est in ovariectomized (Ovx) and Sham rats that were treated with DOCA- salt was evaluated.Materials and Methods:The female rats were divided into 10 groups as follows: Sham, Ovx, Sham-DOCA, Ovx-DOCA, Sham-DOCA-estrogen (E), Ovx DOCA-E, Sham-DOCA-losartan (L), Ovx-DOCA-L, Sham–DOCA-L-E, and Ovx-DOCA-L-E. The Est groups received estradiol valerate (2 mg/kg; daily; subcutaneously (s.c)) for four weeks. Following that, several doses of Ang II (0.5, 5, 50, 500, 5000 ng/5 μl) were injected via the intracerebroventricular (i.c.v) route and the changes in systolic blood pressure (SBP) were evaluated. In the losartan groups, 200 μg losartan was injected (i.c.v) 15 minutes after the Ang II injection and the blood pressure was recorded. Treatment by DOCA was performed by removal of one kidney, injection of DOCA (45 mg/kg i.p), and adding of sodium chloride (NaCl) (1%) and potassium chloride (KCl) (0.1%) in the drinking water.Results:The SBP was increased by Ang II and this effect in DOCA-salt treated rat was higher than in the untreated groups. The effect of Ang II on SBP in groups that were treated with Est and L was lower than that in the DOCA-salt groups. Increase in SBP was strongly attenuated by Ang II in groups that were co-treated with both Est and L compared to the DOCA-treated rats. These results showed that Est significantly attenuated the effect of central Ang II on SBP in the DOCA-salt treated rats.Conclusion:We suggest that there are interactions between E and Ang II in the control of blood pressure in DOCA-salt treated rats.

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Angiotensin converting enzyme inhibitor captopril modifies conditioned place preference induced by morphine and morphine withdrawal signs in rats

Cited by 12 publications

References 40 publications

Effects of the adenosinergic system on the expression and acquisition of sensitization to conditioned place preference in morphine-conditioned rats

Effects of the adenosinergic system on the expression and acquisition of sensitization to conditioned place preference in morphine-conditioned rats

Treadmill exercise reduces self-administration of morphine in male rats

Interaction of central Angiotensin II and estrogen on systolic blood pressure in female DOCA-salt treated rats

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