Effects of the adenosinergic system on the expression and acquisition of sensitization to conditioned place preference in morphine-conditioned rats

Listos, Joanna; Talarek, Sylwia; Listos, Piotr; Orzelska, Jolanta; Łupina, Małgorzata; Fidecka, Sylwia

doi:10.1007/s00210-015-1190-6

Cited by 11 publications

(8 citation statements)

References 51 publications

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“…On the other hand, the same ligands inhibited the acquisition of sensitization to morphine-evoked CPP [ 100 ]. Supporting the last pharmacological study, the rewarding effects of morphine (5 or 10 mg/kg) in CPP were not completely observed in mice lacking A 2A Rs as opposed to wild-type animals [ 81 ].…”

Section: A 2a R and Behavioral Actions To Cocaimentioning

confidence: 99%

Adenosine A2AReceptors in Substance Use Disorders: A Focus on Cocaine

Wydra

Gawliński

Gawlińska

et al. 2020

Cells

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Several psychoactive drugs can evoke substance use disorders (SUD) in humans and animals, and these include psychostimulants, opioids, cannabinoids (CB), nicotine, and alcohol. The etiology, mechanistic processes, and the therapeutic options to deal with SUD are not well understood. The common feature of all abused drugs is that they increase dopamine (DA) neurotransmission within the mesocorticolimbic circuitry of the brain followed by the activation of DA receptors. D2 receptors were proposed as important molecular targets for SUD. The findings showed that D2 receptors formed heteromeric complexes with other GPCRs, which forced the addiction research area in new directions. In this review, we updated the view on the brain D2 receptor complexes with adenosine (A)2A receptors (A2AR) and discussed the role of A2AR in different aspects of addiction phenotypes in laboratory animal procedures that permit the highly complex syndrome of human drug addiction. We presented the current knowledge on the neurochemical in vivo and ex vivo mechanisms related to cocaine use disorder (CUD) and discussed future research directions for A2AR heteromeric complexes in SUD.

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Section: A 2a R and Behavioral Actions To Cocaimentioning

confidence: 99%

Adenosine A2AReceptors in Substance Use Disorders: A Focus on Cocaine

Wydra

Gawliński

Gawlińska

et al. 2020

Cells

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“…Sensitization to the effects of morphine is mediated through the different brain regions and neurotransmitter systems ( Aguilar, Manzanedo, Do Couto, Rodríguez-Arias, & Miñarro, 2009 ; Chefer & Shippenberg, 2009 ; Farahrmandfar, Zarrindast, Kadivar, Karimian, & Naghdi, 2011 ; Fu et al, 2012 ; Listos et al, 2016 ; Manzanedo, Aguilar, Do Couto, Rodríguez-Arias, & Miñarro, 2009 ; Sahraei et al, 2006 ; Vigano et al, 2003 ). the GABAergic system is among the neurotransmitter systems with an important role in the sensitization.…”

Section: Discussionmentioning

confidence: 99%

Effects of Isoniazid on Tolerance and Sensitization to the Rewarding Properties of Morphine: A Conditioned Place Preference Procedure Investigation in Mice

Barzegari

Shahabi

2020

Basic Clin. Neurosci. J.

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Introduction: The GABAergic system of the brain plays a key role in morphine tolerance and sensitization. As isoniazid is a modulator of the GABAergic system, the present study aims to understand whether isoniazid can influence the induction of tolerance and sensitization to the rewarding effects of morphine. Methods: The rewarding effects of morphine and isoniazid were assessed using a Conditioned Place Preference (CPP) procedure in female mice. Tolerance to the rewarding effects of morphine was induced with high-dose morphine (25 mg/kg, SC), twice a day, for four days. Also, the sensitization was induced with an effective dose of morphine (5 mg/kg, SC), once a day, for three days. During the induction of tolerance or sensitization, the different groups of mice received saline or isoniazid (25, 50, and 75 mg/kg, IP) one hour before each morphine injection. Results: Morphine (0.5–10 mg/kg, SC) produced a significant CPP, but isoniazid (25, 50, and 75 mg/kg, IP) did not induce place preference or place aversion in mice. Although an effective dose of morphine (5 mg/kg, SC) did not induce CPP in morphine tolerated mice, an ineffective dose (0.5 mg/kg, SC) could produce a significant CPP in morphine-sensitized animals. The administration of isoniazid before morphine (on the days of tolerance or sensitization induction) inhibited the development of tolerance or sensitization to the rewarding effect of morphine in the CPP paradigm. Conclusion: Isoniazid can be a useful drug for the prevention of tolerance and sensitization to the rewarding effects of morphine.

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“…In all experiments, the CPP procedure was used to examine the effects of risperidone on morphine‐induced place preference. All place conditioning procedures used a biased, counterbalanced conditioning protocol as described previously (Ahmadian et al., 2019; Listos et al., 2016).…”

Section: Methodsmentioning

confidence: 99%

Effect of risperidone on morphine‐induced conditioned place preference and dopamine receptor D2 gene expression in male rat hippocampus

et al. 2023

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Background: Previous studies suggest the possible effect of risperidone on brain reward system and D1 and D2 dopamine receptors' involvement in morphine-induced conditioned place preference (CPP). Aims:The present study was designed to investigate the effect of risperidone as an atypical antipsychotic drug on morphine-induced CPP and D2-like dopamine receptor gene expression in rat. Materials and Methods:An unbiased CPP paradigm was used to study the effect of risperidone. Intraperitoneal (i.p.) injection of risperidone (1, 2, and 4 mg/kg) was performed 30 min before the morphine (10 mg/kg, i.p.) injection and just after the rat was placed in the CPP box. The open field test was used to assay the locomotor activity of animal. The gene expression of D2 dopamine receptor in hippocampus was measured by real-time PCR technique. The hippocampi of rats were also used for histology evaluation.Results: Morphine-produced (10 mg/kg) CPP and morphine-induced CPP were reversed only by the administration of a low dose of risperidone (1 mg/kg). Low dose of risperidone (1 mg/kg) showed no effect on locomotor activity but a higher dose of risperidone (2 and 4 mg/kg) decreased locomotor activity. Real-time PCR data analysis revealed that the gene expression of D2 dopamine receptor had significant difference between morphine and a 1 mg/kg dose of risperidone. Moreover, in histological evaluation, apoptosis was observed in the morphine group, whereas there was no evidence of apoptosis in the risperidone-treated groups. Conclusion:Our results suggest that risperidone (1 mg/kg) reverses the morphineinduced CPP and may reduce the rewarding properties of morphine. It is also demonstrated that risperidone decreases the expression of D2 receptor in rat hippocampus. Therefore, risperidone can be considered potential adjunct therapy in morphine dependence.

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Effects of the adenosinergic system on the expression and acquisition of sensitization to conditioned place preference in morphine-conditioned rats

Cited by 11 publications

References 51 publications

Adenosine A2AReceptors in Substance Use Disorders: A Focus on Cocaine

Adenosine A2AReceptors in Substance Use Disorders: A Focus on Cocaine

Effects of Isoniazid on Tolerance and Sensitization to the Rewarding Properties of Morphine: A Conditioned Place Preference Procedure Investigation in Mice

Effect of risperidone on morphine‐induced conditioned place preference and dopamine receptor D2 gene expression in male rat hippocampus

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