Angiotensin-converting enzyme I/D polymorphism in chronic obstructive pulmonary disease

Pabst, Stefan; Theis, Bernhard; Gillissen, Adrian; Lennarz, Martina; Tuleta, Izabela; Nickenig, Georg; Skowasch, Dirk; Grohé, Christian

doi:10.1186/2047-783x-14-s4-177

Cited by 17 publications

(12 citation statements)

References 30 publications

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“…Unless no correlation was found between COPD incidence and ACE variants, the I/D polymorphism was shown to be involved into muscular work efficiency in COPD patients. 4 Another study 5 has shown that presence of ACE I-allele may predispose for a stable course of COPD (<3 exacerbations per year). A well-studied 287-bp insertion/deletion (ACE I/D) polymorphism in intron 12 is a known predictive marker for hypertension and cardiovascular diseases, with D allele being associated with higher ACE-1 production.…”

Section: Introductionmentioning

confidence: 99%

Common intronic D variant of ACE gene is associated with endothelial dysfunction in COPD

Кузубова

Чухловин

Morozova

et al. 2013

Respiratory Medicine

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Section: Introductionmentioning

confidence: 99%

Common intronic D variant of ACE gene is associated with endothelial dysfunction in COPD

Кузубова

Чухловин

Morozova

et al. 2013

Respiratory Medicine

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“…Angiotensin II is a powerful vasopressor, which regulates blood pressure and fluid and electrolyte balance, chiefly through biosynthesis of aldosterone [53][54] . Association between I/D polymorphism of the ACE gene and the risk for COPD is a very timely and widely studied issue; however, existing data need to be clarified and appended [55][56][57] . The low activity of ACE was recognized to play a positive role in the development of COPD 58 .…”

Section: Discussionmentioning

confidence: 99%

The role of insertion-deletion polymorphism of the ACE gene in development of arterial hypertension in patients with chronic obstructive pulmonary disease

Maksiv

Krynytska

Koval

2020

Bangladesh J Med Sci

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Objective. This study aims to establish the role of insertion-deletion polymorphism of the angiotensin-converting enzyme gene in development of arterial hypertension in patients with chronic obstructive pulmonary disease. Materials and Methods: The study group consisted of 96 patients: Group 1 (25 individuals with COPD), Group 2 (23 individuals with AH), Group 3 (28 individuals with COPD and AH). The control group consisted of the 20 healthy subjects. I/D genotypes of ACE were determined by polymerase chain reaction (PCR) amplification. Plasma ACE activity was determined photometrically by a commercially available kit. Results and Discussion: The distribution of polymorphic variants of the ACE gene among COPD-only patients genotype spreading was close to the data obtained in controls. In hypertensive patients, there were fewer ID heterozygotes and more ІІ homozygotes compared to controls. In the COPD+AH category of patients, II genotype was predominant in 7.1% subjects, DD genotype was predominant in 10.0% subjects and the proportion of ID heterozygotes was 17.1% lower compared to controls. The II genotype had a positive relationship with patient age and a negative relationship with body weights and respiratory rates of COPD+AH patients. The ID genotype was associated with increased respiratory rates; however, its correlation with the duration of the disease was negative. Conclusion: The data obtained in the study allow suggesting that polymorphism of the ACE gene doesn’t relate to development of AH in patients with COPD. The highest activity of ACE was found in patients with combination of COPD and AH; maximum findings of ACE activity were seen in patients with DD genotype. Bangladesh Journal of Medical Science Vol.19(3) 2020 p.543-551

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“…Association between I/D polymorphism of the ACE gene and the risk for COPD is a very timely and widely studied issue; however, existing data need to be clarified and appended (15,26,27). The low activity of ACE was recognized to play a positive role in the development of COPD (28). It is worth noting that the DD genotype of ACE is generally associated with increased circulating and cellular levels of ACE and increased cardiovascular risk (29).…”

Section: Discussionmentioning

confidence: 99%

Comorbidities and medical course in a young patient diagnosed with severe obstructive sleep apnea

et al. 2019

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Background Cardiovascular diseases (CVDs) are common in people with chronic obstructive pulmonary disease (COPD), and their presence is associated with an increased risk for hospitalization, longer length of stay and all-cause and CVD-related mortality. We assessed the role of angiotensin-converting enzyme (ACE) gene polymorphism in the occurrence of arterial hypertension (AH) in patients with COPD. Methods The study group consisted of 96 patients. Group 1 had 25 individuals with COPD, Group 2 had 23 individuals with AH and Group 3 had 28 individuals with COPD and AH. The control group consisted of 20 healthy subjects. I/D genotypes of ACE were determined by polymerase chain reaction amplification. Results The frequency distribution of polymorphic genotypes of the gene encoding ACE and assessment of compliance with the Hardy-Weinberg population equilibrium were carried out in groups of patients with COPD, AH and COPD + AH combination. The frequencies of the genotype responsible for I/D polymorphism of the ACE gene in the control and experimental groups were not found to deviate significantly from the Hardy–Weinberg equilibrium. The results of the study have not demonstrated any significant impact of alleles of ACE genes or ACE genes on occurrence of diseases such as COPD, AH and combinations thereof. However, analysis of odds ratio has demonstrated that the presence of the D allele of the ACE gene may increase the risk for occurrence of the COPD + AH (OR = 1.26). Conclusion The data obtained in the study allow suggesting that the presence of D allele of the ACE gene may increase the risk for AH in patients with COPD.

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Angiotensin-converting enzyme I/D polymorphism in chronic obstructive pulmonary disease

Cited by 17 publications

References 30 publications

Common intronic D variant of ACE gene is associated with endothelial dysfunction in COPD

Common intronic D variant of ACE gene is associated with endothelial dysfunction in COPD

The role of insertion-deletion polymorphism of the ACE gene in development of arterial hypertension in patients with chronic obstructive pulmonary disease

Comorbidities and medical course in a young patient diagnosed with severe obstructive sleep apnea

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