Angiosarcoma of the skull.Report of a case and review of the literature

Chow, Robert W.; Wilson, Charles B.; Olsen, Earl R.

doi:10.1002/1097-0142(197004)25:4<902::aid-cncr2820250424>3.0.co;2-1

Cited by 26 publications

(2 citation statements)

References 3 publications

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“…I shall return to the epidemiological aspects of this group of angiosarcomas when discussing their aetiology. Angiosarcomas taking their origin in the oral cavity, or in the deep soft tissue and bones of the face and head, such as are reported by Wesley et al (i975)j Fu & Perzin (1971) and Chow et al (1970) are beyond the scope of this presentation. Patients were included in this analysis on the basis of reasonably adequate information concerning clinical presentation and subsequent course, with availability of biopsies or surgical specimens showing undoubted angiosarcoma as previously defined (Wilson Jones, 1964).…”

mentioning

confidence: 72%

Malignant vascular tumours*

Jones

1976

Clin Exp Dermatol

183

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mentioning

confidence: 72%

Malignant vascular tumours*

Jones

1976

Clin Exp Dermatol

183

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“…[3] Metastasis usually occurs to the bone and lungs. [6] According to Mark et al ., in a report of 67 patients with angiosarcoma, 52 patients developed recurrences after primary treatment. Of these 52, 42 patients had a component of local failure and 28 patients had developed distant metastases at last follow-up.…”

Section: Discussionmentioning

confidence: 99%

Primary angiosarcoma of the skull: A rare case report

Chugh¹,

Gandhoke²,

Mohite³

et al. 2014

Surg Neurol Int

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Background:Angiosarcomas are rare high grade endothelial tumors characterized by rapidly proliferating anaplastic cells derived from blood vessels and lining irregular blood filled spaces. Primary neoplasms of the skull are rare, representing 2.6% of primary neoplasms of bone. Primary malignant neoplasms of the skull are even rarer, accounting for only 0.8% of primary malignant neoplasms of bone.Case Description:We report a 32-year-old female who presented with right parieto-occipital swelling, which gradually increased in size. Radiology was suggestive of a calvarial soft tissue lesion in the right parieto-occipital region with destruction of the adjacent parieto-occipital bone with intracranial extra-axial extension. Complete surgical excision of the calvarial lesion was done under general anesthesia. Postoperative computed tomography (CT) scan of brain (plain and with contrast) showed complete excision of the tumor mass. Histopathological diagnosis was consistent with ‘an angiosarcoma of the skull’. On immunohistochemistry, the atypical endothelial cells were highlighted by CD34, CD31, and factor VIII-related antigen. The patient received adjuvant radiotherapy to the tumor bed.Conclusion:Primary angiosarcoma of the skull is a rare tumor with less than 20 cases reported worldwide till date. The treatment should include complete surgical excision with a wide bony margin followed by adjuvant radiotherapy, which in our case has given a good locoregional control even at the end of 2 years. However, these patients should be followed up with repeated scans yearly to rule out locoregional as well as distant recurrence.

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Hemangioma, hemangiopericytoma, and hemangioendothelioma (angiosarcoma) of bone

Unni

Ivins

Beabout³

et al. 1971

Cancer

209

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Sixty‐nine cases of bone tumors of vascular origin, excluding cases of lymphangiomas and massive osteolysis, were found in a complete review of the surgical files of the Mayo Clinic. There were 56 hemangiomas, and these often produced roentgenologic diagnostic problems. Most were easily managed surgically, although some vertebral hemangiomas required radiation therapy. There were known multicentric lesions in only 2 of the 56 cases. Hemangiopericytomas accounted for 4 of the 69 cases. In these 4, the clinical courses were characteristically unpredictable. There were 9 hemangioendotheliomas. These 9 were added to 13 cases in which specimens were submitted for review. In 6 of the 22 cases, there was multifocal involvement. In this group of 22 cases, it was impractical to differentiate a separate group and designate it as angiosarcoma. Half of the 22 patients died, 1 of known unrelated disease. Surgical extirpation, when possible, and irradiation of lesions incompletely excised or surgically inaccessible seem logical principles in treatment. In these cases of hemangioendotheliomas, the most important indicator of prognosis was the grade of anaplasia.

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Angiosarcoma of the skull.Report of a case and review of the literature

Cited by 26 publications

References 3 publications

Malignant vascular tumours*

Malignant vascular tumours*

Primary angiosarcoma of the skull: A rare case report

Hemangioma, hemangiopericytoma, and hemangioendothelioma (angiosarcoma) of bone

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