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Of 370 well‐differentiated chondrosarcomas, 33 had dedifferentiated zones of fibrosarcoma or osteogenic sarcoma. The clinical characteristics, including long preoperative duration of symptoms, age distribution of patients, and skeletal localization, and certain roentgenographic features correlated well with the chondrosarcomatous component of these tumors. The rapid deterioration of most of the patients after operation was determined by, and characteristic of, the anaplastic portion of the tumor and indicated the need for radical treatment at the earliest practicable date.

This retrospective review is the largest series on benign giant-cell tumor of bone with histologically benign pulmonary metastases. The paradox of a metastasizing "benign" tumor is well documented, and numerous cases have been reported [1 -7]. The lungs are the principal site of metastases, and the pulmonary lesions are pathologically indistinguishable from the primary tumor. Although many cases of giant-cell tumor with pulmonary metastases have been reported from an orthopedic perspective, this topic has received little consideration in radiologic literature. We reviewed both the dinical findings and the radiologic appearance of benign giant-cell tumor of bone with pulmonary metastases and herein report our experience. Materials and MethodsApproximately 9000 patients with primary bone tumors were seen at our institution before 1990. Of these, 475 patients had benign giant-cell tumors of bone. We reviewed the medical records of all patients in whom benign giant-cell tumor of bone was diagnosed, and we selected only those patients who also had histologically proved benign pulmonary metastases.Benign giant-cell tumor was characterized by the absence of atypical nuclei and a high mitotic rate. Thirteen (3%) of the 475 patients fulfilled our criteria. Clinical and pathologic information was obtained from the medical records, and radiologic examinations were evaluated. Patients were followed up for a mean of 1 1 years (range, 1-24 years).