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A 25-year-old man died after an intravenous injection of 100 mg of methedrine. Postmortem studies showed visceral congestion, lung edema, pericardial petechiae, centrolobular necrosis of the liver, and diffuse subarachnoid blood, intracranial vasculitis and cerebritis in the absence of aneurysms, arteriovenous malformations or chronic hypertension. A review of the English-language literature produced 3 other cases of fatal amphetamine-induced intracranial hemorrhage and seven nonfatal cases. Some were the result of overdose, others of hypersensitivity. Angiographic evidence suggests that such hemorrhages result from the development of fibrinoid necrosis and the formation of microaneurysms in the small intracerebral vessels.

An osteolytic lesion of the frontal skull that bled profusely at biopsy proved to be a highly anaplastic angiosarcoma. Follow-up roentgenograms showed invasion of the tumor into adjacent diploic spaces. Over a period of 6 weeks, 6,000 rads were delivered to the lesion in 34 treatments. When the lesion and From the Division

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