Angiomyolipoma of the liver: Case report and collective review of cases diagnosed from fine needle aspiration biopsy specimens

Sawai, Hirozumi; Manabe, Tadao; Yamanaka, Yuji; Kurahashi, Shingo; Kamiya, Atsushi

doi:10.1007/s005340050055

Cited by 28 publications

(11 citation statements)

References 8 publications

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“…8 MHLs of adulthood with a prominent stromal component may require differential diagnosis from mesenchymal tumors, including leiomyoma, sclerosing hemangioma, angiomyxoma, and angiomyolipoma. 30 We did not have a differential diagnosis problem in our first patient, but we need to be sure of the topographical location of MHL as such large vessels and ductal structures may be observed in the porta hepatis. In the second patient, the stromal component was not prominent, and the lesion consisted of cystic dilated structures lined by flattened epithelium; we had a problem with differential diagnosis from a vascular tumor such as lymphangioma.…”

Section: Discussionmentioning

confidence: 94%

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Mesenchymal hamartoma of the liver in adulthood: immunohistochemical profiles, clinical and histopathological features in two patients

Gürbüz

Turan

Zafer

et al. 2005

J Hepatobiliary Pancreat Surg

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Mesenchymal hamartoma is an uncommon cystic mass of the liver which occurs primarily in children. There are a few reports of its occurrence in adulthood. Here, we present two cases in female patients, 54 and 51 years old. Radiological examinations in both patients showed multiple cystic lesions in the liver. Surgically, total cystectomy was performed in the first patient, while an unroofing procedure was done in the second patient (due to misdiagnosis of the lesion as a simple cyst of the liver). On microscopic examinations of the lesion in each patient, a multilocular cyst was observed, lined by flattened epithelium and surrounded by a mesenchymal component composed of mature connective tissue, arterial and venous vascular structures, peripheral nerve bundles, and ductal structures. An immunohistochemical panel consisting of desmin, smooth-muscle actin, S-100, vimentin, CD34, carcinoembryonic antigen, pancytokeratin, cytokeratin 7, cytokeratin 8, cytokeratin 17, cytokeratin 18, cytokeratin 19, and cytokeratin 20 was applied to paraffin sections. Immunoreactivity for cytokeratin 7 and cytokeratin 19 was observed in cystic epithelium and ductal structures. Focal and patchy desmin immunoreactivity was observed in connective tissue. S-100 was positive only in peripheral nerve bundles. In conclusion, mesenchymal hamartoma of the liver in adulthood is a localized tumoral abnormality that precedes birth, and which has delayed clinical presentation. These lesions seems to be related to a maturation process. During this period of maturation, immature edematous stroma rich in mucopolysaccharides may convert to mature paucicellular hyalinized connective tissue. This maturation process may be also related to loss of premalignant potential of these tumors.

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Section: Discussionmentioning

confidence: 94%

“…BMCAWOS is observed in fertile women, with the epithelial component being composed of goblet cells, and with ovarian stroma 8. MHLs of adulthood with a prominent stromal component may require differential diagnosis from mesenchymal tumors, including leiomyoma, sclerosing hemangioma, angiomyxoma, and angiomyolipoma 30…”

Section: Discussionmentioning

confidence: 99%

Mesenchymal hamartoma of the liver in adulthood: immunohistochemical profiles, clinical and histopathological features in two patients

Gürbüz

Turan

Zafer

et al. 2005

J Hepatobiliary Pancreat Surg

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“…In the series reported by Sawai et al, ®ve cases of hepatic angiomyolipoma were diagnosed by FNAB [11]. Histologically, the hepatic angiomyolipoma consists of varying proportions of three elements, mature fat cells, blood vessels, and smooth muscle cells [10].…”

Section: Discussionmentioning

confidence: 97%

Angiomyolipoma of the liver

Yeh

Chen

Hung

et al. 2001

Journal of Surgical Oncology

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Hepatic angiomyolipoma is a rare and benign entity. It has a wide variation and poses a diagnostic challenge clinically, radiologically, and pathologically. Its prognosis is good regardless of management, including hepatic resection or conservative treatment after tissue biopsy by echo-guided needle. To alleviate the mass effect, surgical resection may be needed for hepatic angiomyolipoma in selected cases.

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“…Angiomyolipoma is a mesenchymal neoplasm comprised of varying proportions of adipose, blood vessels, and smooth muscle 1–3 . Primary AMLs occur most frequently in the kidneys; the liver is the second most common location 1,2 .…”

Section: Discussionmentioning

confidence: 99%

Fine needle aspiration of hepatic angiomyolipoma with extramedullary hematopoiesis: A case report

et al. 2022

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Angiomyolipoma (AML), a perivascular epithelioid cell tumour, is a benign tumour, typically involving the kidney. In this location, the cytological and histological characteristics of this lesion allow for a straightforward diagnosis in most cases. When AML occurs in extrarenal sites such as the liver, AML can mimic a malignant tumour clinically and radiologically. 1 A definitive diagnosis of hepatic angiomyolipoma (HAML) usually relies on histopathological evaluation of biopsy or resection material. A diagnosis of HAML is less often made, or at least suspected, on cytology specimens obtained using techniques such as fine needle aspiration (FNA). 1 In this setting, the interpretation can be challenging. We report a case of HAML with extramedullary hematopoiesis (EMH) presenting as a large hepatic mass, diagnosed by cytology through endoscopic ultrasound guided fine-needle aspiration. | C A S E REP ORTAn 81-year-old man with a history of chronic kidney disease stage III and diabetes was found to have an incidental 6 cm well-circumscribed mass in the left lobe of the liver mass on computed tomography (CT).The mass showed central low density suggestive of a scar, and focal nodular hyperplasia was suggested as an initial diagnosis. FNA of the lesion showed a mixture of spindled and epithelioid cells in a background of mixed histiocytes, plasma cells, and eosinophils (Figure 1).The epithelioid cells displayed abundant cytoplasm, round nuclei with prominent a nucleolus, and rare binucleated forms. In addition, the cellblock demonstrated mature adipose tissue and rare megakaryocytes suggestive of extramedullary hematopoiesis (Figure 2). Immunohistochemical staining of the cellblock showed positivity for HMB-45 and Mart-1 (weak), as well as absence of CD45,

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Angiomyolipoma of the liver: Case report and collective review of cases diagnosed from fine needle aspiration biopsy specimens

Cited by 28 publications

References 8 publications

Mesenchymal hamartoma of the liver in adulthood: immunohistochemical profiles, clinical and histopathological features in two patients

Mesenchymal hamartoma of the liver in adulthood: immunohistochemical profiles, clinical and histopathological features in two patients

Angiomyolipoma of the liver

Fine needle aspiration of hepatic angiomyolipoma with extramedullary hematopoiesis: A case report

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