Angioma serpiginosum with extensive cutaneous involvement

Katta, Rajani; Wagner, Annette

doi:10.1016/s0190-9622(00)90119-1

Cited by 47 publications

(40 citation statements)

References 8 publications

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“…However, it is difficult to categorize this disorder according to the foregoing classification of mosaic patterns. A similar asymmetric arrangement of AS lesions has been noted by some previous authors [5,6,7]. On the other hand, it remains conceivable that in some other previous case reports, the AS lesions followed the lines of Blaschko [8, 9].…”

Section: Discussionsupporting

confidence: 84%

“…As initially noted by Hutchinson [1], it appears most frequently in adolescent females, with the legs being the areas of predilection. The disorder is often arranged in an asymmetric or otherwise segmental pattern [3,4,5,6] that may also involve the trunk [5, 7]. Sometimes, the distribution of lesions may even be reminiscent of the lines of Blaschko [8, 9].…”

Section: Introductionmentioning

confidence: 99%

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Angioma Serpiginosum Arranged in a Systematized Segmental Pattern Suggesting Mosaicism

Chen

Liu²,

Yang³

et al. 2006

Dermatology

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In a 15-year-old Taiwanese girl, multiple purple punctate lesions arranged in a systematized, segmental pattern had developed since childhood, beginning from the right thigh and gradually progressing upwards to the right buttock, the left side of the abdomen, circumventing to the left side of the back, and extending to the right arm as well as to the posterolateral aspect of the left leg. Histopathological examination showed dilated capillaries in the uppermost part of the dermal papillae characteristic of angioma serpiginosum. The systematized, segmental and asymmetric arrangement of lesions as noted in the present case suggest that angioma serpiginosum reflects genetic mosaicism.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Angioma Serpiginosum Arranged in a Systematized Segmental Pattern Suggesting Mosaicism

Chen

Liu²,

Yang³

et al. 2006

Dermatology

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“…Extensive affection of the skin is rare. 4,12,16 The palms and soles are not affected, nor is the oral mucosa.…”

Section: Introductionmentioning

confidence: 99%

Angioma serpiginosum with oesophageal papillomatosis is an X-linked dominant condition that maps to Xp11.3–Xq12

et al. 2007

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We report on a four-generation family with localized subepidermal telangiectasias following Blaschko's lines (angioma serpiginosum). The vascular streaks are present at birth and progress slowly thereafter. In several family members papillomatosis of the entire oesophagus was found to be part of the condition. Mild nail and hair dystrophy added to the resemblance of Goltz -Gorlin syndrome (focal dermal hypoplasia), suggesting that the present condition could be a mild variant. All affected family members are females, there is no increased miscarriage rate, and X-inactivation in affected females is highly skewed, compatible with X-linked dominant inheritance with very early in utero lethality in males. In the family, 11 informative meioses were available to study the segregation of X-chromosome markers. Significant linkage (LOD score 3.31) was found to a region flanked by markers DXS8026 and DXS106 (44 -67 Mb from Xpter) that includes the centromere.

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“…Involvement in a Blaschkoid pattern may be seen [5]. Bilateral involvement is usually seen in those cases where there is extensive body surface area involvement [6,7]. We could not find any report with limited cutaneous involvement presenting bilaterally.…”

mentioning

confidence: 70%

“…Zmiany mogą mieć układ zgodny z liniami Blaschko [5]. W przypadku zajęcia dużych obszarów skóry zazwyczaj stwierdza się obustronne występowanie choroby [6,7]. W piśmiennictwie nie odnaleziono żadnego przypadku obustronnego ograniczonego zajęcia skóry.…”

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Late onset bilateral angioma serpiginosum involving upper limbs in a male: a rare presentation

Arif¹,

Adil²,

Amin³

et al. 2017

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Late onset bilateral angioma serpiginosum involving upper limbs in a male: a rare presentation Rzadki przypadek naczyniaka pełzakowatego o późnym początku z obustronnym zajęciem kończyn górnych u pacjenta płci męskiej Tasleem Angioma serpiginosum (AS) is a rare vascular disorder characterized by punctate red macules in a nevoid distribution arranged in groups to form a serpiginous pattern [1]. The disease is usually seen in late childhood in females and mostly occurs unilaterally over the lower extremity.We report a case of bilateral AS on the upper extremities and chest in a 22-year-old male patient. Late onset (over 20 years of age), bilaterality, male sex and involvement of upper extremity add rarity to our case presentation and warrant its reporting.A 22-year-old male presented with asymptomatic, red coloured lesions over the right side of chest and both arms. The lesions initially began on the chest one year back and gradually spread to involve the right and left arms. The patient was otherwise apparently healthy, and no family history of a similar disease was present. On physical examination, he was found to have multiple, punctate, grouped, red macules over the anterolateral chest on the right side, extending from just above the nipple to the anterior axillary fold and both upper arms up to the mid-forearms in a serpiginous pattern (Figs. 1 A-C). The lesions were not blanchable on diascopy. However, Darier's sign was negative. The rest of the cutaneous and systemic examination was unremarkable. Laboratory tests including blood counts and serum biochemistry were within the normal range. Serum testosterone and oestrogen levels were normal. Skin biopsy from the chest showed normal epidermis and dilated tortuous vessels in the upper dermis and dermal papillae, without inflammation or pigment deposition (Fig. 2). Toluidine blue stain for mast cells did not reveal any infiltrating mast cells. Based on the clinical Naczyniak pełzakowaty (angioma serpiginosum -AS) jest rzadkim schorzeniem naczyniowym, charakteryzuje się obecnością punkcikowatych czerwonych plamek o rozmieszczeniu newoidalnym, występujących w skupiskach, szerzących się obwodowo [1]. Choroba pojawia się zwykle w okresie późnego dzieciństwa u dziewczynek i przebiega zazwyczaj z zajęciem koń-czyny dolnej po jednej stronie ciała.W pracy opisano przypadek 22-letniego pacjenta płci męskiej, u którego rozpoznano AS zlokalizowanego obustronnie w obrębie kończyn górnych i klatki piersiowej. Przypadek zasługuje na uwagę ze względu na późny początek choroby (po 20. roku życia), obustronne zajęcie skóry kończyn górnych oraz płeć męską pacjenta.U 22-letniego mężczyzny wystąpiły bezobjawowe, czerwone zmiany skórne umiejscowione po prawej stronie klatki piersiowej oraz na obu ramionach. Zmiany pojawiły się po raz pierwszy rok wcześniej, początkowo na skórze klatki piersiowej, skąd rozprzestrzeniły się stopniowo na prawe i lewe ramię. Poza objawami skórnymi pacjent był zdrowy. W wywiadzie rodzinnym nie było przypadków podobnego schorzenia. Badanie fizykalne wyka...

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Angioma serpiginosum with extensive cutaneous involvement

Cited by 47 publications

References 8 publications

Angioma Serpiginosum Arranged in a Systematized Segmental Pattern Suggesting Mosaicism

Angioma Serpiginosum Arranged in a Systematized Segmental Pattern Suggesting Mosaicism

Angioma serpiginosum with oesophageal papillomatosis is an X-linked dominant condition that maps to Xp11.3–Xq12

Late onset bilateral angioma serpiginosum involving upper limbs in a male: a rare presentation

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