Angiolymphoid Hyperplasia With Eosinophilia: A Clinicopathologic Study of 9 Cases

Angiolymphoid hyperplasia with eosinophilia: report of nine cases

“…Published reports of ALHE are conflicting about sex ratio. A female predominance is reported in a Spanish series of nine cases with a sex ratio of 0.8 and in a Tunisian series of seven cases with a sex ratio of 0.75, which is similar to our results. However, a male predominance is noted by the US Armed Forces Institute of Pathology in a series of 116 patients .…”

“…7 Other locations such as trunk, lower extremities, hands, penis, oral mucosa, and colon are rare and often associated with cephalic lesions. 4,[8][9][10] Regional lymphadenopathy is very rare, seen in 11% of our patients and 5-10% of reported cases. Peripheral blood eosinophilia is noted in 10-20%.…”

“…The most common locations are periauricular area (36.3%), face (28.2%), and scalp (17.3%) . Other locations such as trunk, lower extremities, hands, penis, oral mucosa, and colon are rare and often associated with cephalic lesions …”

Hiperplasia Angiolinfoide: Reporte De Un Caso Inusual en Cavidad Oral

“…2 Its pathogenesis is unknown, but it is considered to be a reactive disorder induced by various stimuli, including vascular malformations, trauma, and pregnancy. 3 The presence of high serum estrogen levels (also the case in the use of oral contraceptives) is one of the hypotheses; however, currently the most accepted theory is that of a reactional vascular hyperplasia caused by different stimuli. 4 A case of dermal ALHE was found to harbor a mutation in the TEK gene, which encodes the Tie-2 endothelial cell tyrosine kinase receptor, showing that certain molecular alterations may contribute to the pathogenesis of this condition.…”

“…Other diseases that should be considered in differential diagnosis include Kaposi sarcoma, angiosarcoma, and hemangioendothelioma. 3 ALHE is a pathology of low prevalence and it rarely occurs in the oral cavity; when it happens, differential diagnosis includes benign neoplasms of salivary glands (mainly pleomorphic adenoma) and of other tissues such as leiomyoma, neurofibromas, and lipomas.…”