Anesthetic Uptake—Of Mice and Men (and Whales)

Wahrenbrock, Eric A.; Eger, Edmond I.; Laravuso, Raymond B.; Maruschak, Gary F.

doi:10.1097/00000542-197401000-00007

Cited by 45 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Large differences in body mass (e.g. 350 g rats vs a 6300 kg whale) correlate with rate of anaesthetic uptake, 7 and obesity modestly increases uptake of isoflurane-but does not appear to concurrently slow rate of recovery. 8 The faster awakening from sevoflurane than isoflurane, and from desflurane than sevoflurane, reflects progressively smaller blood and tissue solubilities.…”

mentioning

confidence: 99%

Effect of increased body mass index and anaesthetic duration on recovery of protective airway reflexes after sevoflurane vs desflurane

McKay

Malhotra

Çakmakkaya

et al. 2010

British Journal of Anaesthesia

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

Effect of increased body mass index and anaesthetic duration on recovery of protective airway reflexes after sevoflurane vs desflurane

McKay

Malhotra

Çakmakkaya

et al. 2010

British Journal of Anaesthesia

View full text Add to dashboard Cite

show abstract

“…3) with the uptake of these agents in adult humans not given aminophylline (11,12), one sees that both enflurane and halothane were taken up significantly more rapidly in our dogs than in adult humans. However, the uptake of halothane in children aged 1-5 years (13) is very similar In summary, the redistribution ( a ) phase of theophylline is slightly faster when subjects are awake than when anesthesia is induced with enflurane or halothane after aminophylline administration, although the difference would appear to have little clinical import.…”

Section: Discussionmentioning

confidence: 84%

Enflurane, Halothane, and Aminophylline-Uptake and Pharmacokinetics

Berger

Stirt

Sullivan

1983

Anesthesia & Analgesia

View full text Add to dashboard Cite

halothane, and aminophylline-uptake and pharmacokinetics. Anesth Analg 1983;62:733-7. This study was designed to evaluate the effects of induction of enflurane or halothane anesthesia on the distribution and elimination of previously administered intravenous aminoplzylline, and to evaluate the effect of previously administered intravenous aminophylline on the uptake of enflurane or halothane. Fifty-four dogs were studied: 6 received no anesthetic, 24 received enflurane, and 24 haIothane. The six animals receiving no anesthetic were given 10 mglkg of aminophylline. In each of the two groups of 24 animals, six animals served as controls and received no aminophylline. Of the other 18 animals in each group, six received 10 mgl kg of aminophylline, six received 25 mglkg of aminophylline, and six received 50 mglkg of aminophylline intravenously before induction of enfiurnne or ~znlof~znne nizestl~esin. The redistriliufion (4 phase of theuphylline zuas similar when anesthesia was induced with either ei$urane or lialotlinne and slightly more rapid when no anesthetic was given following aminophylline administration. The elirninaticin (p) phase of fheophylline iii the presence of either anesthetic was not significantly different than zohen no ailesthetic zvas administered. The uptake of enflurane or halothatie zons unafected by prior administration of aminophylline. Differences in arrliythmogenicity between eriflurme and hnlothane after arninophylline adiniizistration are riot relatcd to alterations in tkeophylline pharmncokinetics or anesthetic uptake.

show abstract

“…Our absolute MAC values may be low, since 100% equilibration during cyclopropane anaesthesia in normal rats may not be complete within 10 min (Wahrenbrock et al, 1974). As the gas concentration was altered as a stepwise reduction, the brain concentrations may have been higher than the inspired concentrations.…”

Section: Discussionmentioning

confidence: 88%