Enflurane, Halothane, and Aminophylline-Uptake and Pharmacokinetics

Abstract

halothane, and aminophylline-uptake and pharmacokinetics. Anesth Analg 1983;62:733-7. This study was designed to evaluate the effects of induction of enflurane or halothane anesthesia on the distribution and elimination of previously administered intravenous aminoplzylline, and to evaluate the effect of previously administered intravenous aminophylline on the uptake of enflurane or halothane. Fifty-four dogs were studied: 6 received no anesthetic, 24 received enflurane, and 24 haIothane. The six animals receiving no anesthetic were given 10 mglkg of aminophylline. In each of the two groups of 24 animals, six animals served as controls and received no aminophylline. Of the other 18 animals in each group, six received 10 mgl kg of aminophylline, six received 25 mglkg of aminophylline, and six received 50 mglkg of aminophylline intravenously before induction of enfiurnne or ~znlof~znne nizestl~esin. The redistriliufion (4 phase of theuphylline zuas similar when anesthesia was induced with either ei$urane or lialotlinne and slightly more rapid when no anesthetic was given following aminophylline administration. The elirninaticin (p) phase of fheophylline iii the presence of either anesthetic was not significantly different than zohen no ailesthetic zvas administered. The uptake of enflurane or halothatie zons unafected by prior administration of aminophylline. Differences in arrliythmogenicity between eriflurme and hnlothane after arninophylline adiniizistration are riot relatcd to alterations in tkeophylline pharmncokinetics or anesthetic uptake.