Anestesia intravenosa total utilizando propofol ou propofol/cetamina em cadelas submetidas à ovariossalpingohisterectomia

Gasparini, Silvia; Luna, Stélio Pacca Loureiro; Cassu, Renata Navarro; Biasi, F. De

doi:10.1590/s0103-84782009005000102

Cited by 9 publications

(15 citation statements)

References 19 publications

(22 reference statements)

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“…According to the same author, this is an effect directly related to the infusion rate. However, in our study the CRI did not exceed 0.7mg kg -1 minute -1 , which is considered a regular rate for dogs undergoing surgery (Gasparini et al, 2009). …”

Section: Discussioncontrasting

confidence: 41%

“…Induction of anesthesia was accomplished with a 4 mg kg -1 bolus of propofol followed by maintenance at initially 0.4 mg kg -1 minute -1 CRI given by a syringe pump. Animals were intubated and kept under 100% inspired oxygen fraction (FiO 2 = 1.0) breathing spontaneously (Ferro et al, 2005;Gasparini et al, 2009).…”

Section: Methodsmentioning

confidence: 99%

“…In case there were any signs of pain during surgery (HR, f R and arterial pressures up to 10% above previous measures or movement after noxious stimulus), the propofol CRI would be increased in 0.1mg kg -1 minute -1 each time, in order to maintain an adequate depth of anesthesia for surgery (Gasparini et al, 2009).…”

Section: Methodsmentioning

confidence: 99%

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Epidural levobupivacaine alone or combined with different morphine doses in bitches under continuous propofol infusion

Albuquerque¹,

Araújo²,

Ferreira³

et al. 2015

Arq. Bras. Med. Vet. Zootec.

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The aim of this study was to assess the cardiopulmonary, analgesic, adverse effects, serum concentration of cortisol and plasma levels of levobupivacaine and morphine in bitches undergoing propofol anesthesia and epidural analgesia with levobupivacaine alone or combined with morphine. This was a randomized 'blinded' prospective clinical study using 32 adult bitches weighing 9.8±4.1kg that were admitted for elective ovariohysterectomy. Twenty minutes after administration of acepromazine and midazolam, anesthesia was induced with propofol (4mg kg -1 ) and maintained by a continuous rate infusion (CRI). Each animal was randomly assigned to one of four epidural groups: GL = levobupivacaine alone (0.33mg kg -1 ); GLM0.1 = levobupivacaine and morphine (0.1mg kg -1 ); GLM0.15 = levobupivacaine and morphine (0.15mg kg -1 ); and GLM0.2 = levobupivacaine and morphine (0.2mg kg -1 ). Variables obtained during anesthesia were heart rate, respiratory rate, systolic, mean and diastolic arterial blood pressures, oxyhemoglobin saturation, inspired oxygen fraction, end-tidal carbon dioxide tension, blood gases, serum cortisol, and plasma levels of levobupivacaine and morphine. The onset and duration times of the blockade were recorded. Arterial pressures were significantly increased in all groups at the times of ovarian pedicle clamping. There was a decrease in pH, together with an increase in both PaO 2 and PaCO 2 over time. Serum cortisol levels were increased in TESu compared to TB, T30 and TR. Limb spasticity, muscle tremors, opisthotonos and diarrhea were observed in some animals during propofol infusion and ceased with the end of CRI. Reactions happened at different moments and lasted for different periods of time in each individual. Epidural with levobupivacaine alone or combined with morphine allowed for ovariohysterectomy to be performed under low propofol infusion rates, with minimal changes in cardiovascular variables and in serum cortisol levels. Adverse effects were observed in very few animals in each group. Keywords: dog, opioid, ovariohysterectomy, blood gas, regional anaesthesia (0,33mg/kg); GLM0,1 = levobupivacaína + morfina (0,1mg/kg); GLM0,15 = levobupivacaína + morfina (0,15mg/kg) e GLM0,2 = levobupivacaína + morfina (0,2mg/kg RESUMO Objetivou-se avaliar os efeitos cardiovasculares, analgésico, adversos, a concentração sérica de cortisol e os níveis plasmáticos de levobupivacaína e morfina em cadelas submetidas à infusão contínua de propofol e analgesia peridural com levobupivacaína isolada ou associada à morfina. Para tanto, realizou-se um estudo clínico prospectivo randomizado com 32 cadelas adultas pesando 9,8 ± 4,1kg, que foram submetidas à ovário-histerectomia eletiva. Vinte minutos após a administração de acepromazina e midazolam, os animais foram induzidos com propofol (4mg/kg) e mantidos por uma infusão contínua (CRI) do mesmo fármaco. Cada animal foi alocado aleatoriamente em um dos quatro grupos: GL = levobupivacaína isolada

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Section: Discussioncontrasting

confidence: 41%

Section: Methodsmentioning

confidence: 99%

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Epidural levobupivacaine alone or combined with different morphine doses in bitches under continuous propofol infusion

Albuquerque¹,

Araújo²,

Ferreira³

et al. 2015

Arq. Bras. Med. Vet. Zootec.

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“…A dose de IC inicial de 0,34 mg/kg/min de propofol associada a infusão de fentanil, lidocaína ou cetamina nas doses supra citadas não foi suficiente para a manutenção do plano anestésico, por isso foi elevada categoricamente em todos os grupos após transcorridos cinco minutos da indução, ou seja durante este tempo ainda se tinha o efeito do bolus do tratamento analgésico e da indução [2,7]. A avaliação da quantidade utilizada de um anestésico é um método clínico e indireto de quantificação da potencia de um analgésico [5].…”

Section: Discussionunclassified

“…A IC de propofol foi realizada na veia cefálica esquerda através de bomba de infusão tipo seringa (Insight: EFF311) 6 e, a infusão do tratamento analgésico foi realizada através de bomba de infusão peristáltica (Pump:600I) 7 pela veia cefálica direita. Depois de realizada intubação orotraqueal, o animal foi conectado ao circuito anestésico re-inalatório, para o fornecimento de oxigênio a 100% na taxa de 40 mL/kg/min, o mesmo foi posicionado em decúbito dorsal, sob colchão térmico, e mantido em ventilação espontânea.…”

Section: Delineamento Experimentalunclassified

Total Intravenous Anesthesia with Propofol Associated with Fentanyl, Lidocaine or Ketamine in Bitches Submitted to Elective Ovariohysterectomy

Monzem

Spiller

Dower

et al. 2017

Acta Scientiae. Vet.

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Background: Total intravenous anesthesia with propofol is an alternative to inhalation anesthesia because it offers smoother anesthetic recovery, however, since propofol does not have adequate analgesic action, it is necessary to associate it with some drug to avoid the pain process. In addition, the combination may minimize cardiovascular depression resulting from continuous infusion of propofol by reducing infusion rate. The aim of this study was to evaluate cardiorespiratory parameters and anesthetic recovery in bitches submitted to continuous infusion of fentanyl, lidocaine and ketamine associated with total intravenous anesthesia with propofol and submitted to elective ovariohisterectomy.Materials, Methods & Results: Twenty-four bitches were medicated intramuscularly with 0.03 mg/kg of acepromazine. After 30 min, they were divided into three groups with different analgesic treatments: group F (GF) received a loading dose (LD) of 0.0036 mg/kg fentanyl, followed by continuous infusion of 0.0036 mg/kg/h; group L (GL), LD of 3 mg/kg lidocaine, followed by 3 mg/kg/h and group K (GK), LD of 0.6 mg/kg ketamine, followed by 0.6 mg/kg/h. First a LD of analgesic treatment was administered, followed by induction (to the effect) and beginning of continuous infusion of the analgesic treatment and propofol. The animals were intubated with endotracheal tube of adequate size, and connected to 100% oxygen, being kept under spontaneous ventilation during the entire period of anesthetic maintenance. The infusion of propofol started at 0.34 mg/kg/min and was adjusted so as to maintain the surgical anesthesia plane of Guedel and the cardiovascular parameters within the physiological limits for the species. The cardiorespiratory parameters were measured at different moments: basal (before application of any drug) and 5, 15, 20, 30, 40, 50, 60, 70 and 80 min after induction. The surgery started 20 min after anesthetic induction and lasted 60 min. At the end of the surgery, infusions were terminated and anesthesia recovery was evaluated by measuring the extubation time, sternal decubitus, and quadrupedal position in min. A variance analysis was performed to compare means of cardiorespiratory parameters for the moments and groups followed by the Scott-knott test. Differences were considered significant when P < 0.05. The baseline parameters, age, weight and dose of propofol IC were not statistically different between groups. The infusion rate of propofol increased in all groups from M5 to M15. GF and GL presented lower values for heart rate and GK presented higher values for the same variable. Blood pressure decreased after induction and increased in M40, M50 and M60. The variables EtCo2, PaCo2 and HCO3 increased and pH decreased showing respiratory depression in all groups. The mean time, in min, for orotracheal extubation, sternal decubitus and quadrupedal position were respectively 5 ± 3, 20 ± 6 and 39 ± 13 for GF; 6 ± 2, 23 ± 7 and 51 ± 15 for GL; 4 ± 2, 18 ± 6 and 42 ± 22 for GK and did not present statistical difference between the groups.Discussion: The combination of continuous infusion of fentanyl, lidocaine or ketamine to total intravenous anesthesia with propofol provides cardiovascular stability, but does not prevent respiratory function depression. The dose of propofol IC was the same in all groups, thus demonstrating that analgesics have the same potency in the transoperative period and justifies similar anesthetic recovery times. Thus, it can be concluded that these associations are feasible for total intravenous anesthesia provided proper monitorins for respiratory function.

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Total Intravenous Anesthesia With Propofol Associated or Not With Remifentanil, Ketamine, or S-Ketamine for Laparoscopic Ovariectomy in Female Dogs

Sarturi

Teixeira

Coradini

et al. 2021

Topics in Companion Animal Medicine

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Anestesia intravenosa total utilizando propofol ou propofol/cetamina em cadelas submetidas à ovariossalpingohisterectomia

Cited by 9 publications

References 19 publications

Epidural levobupivacaine alone or combined with different morphine doses in bitches under continuous propofol infusion

Epidural levobupivacaine alone or combined with different morphine doses in bitches under continuous propofol infusion

Total Intravenous Anesthesia with Propofol Associated with Fentanyl, Lidocaine or Ketamine in Bitches Submitted to Elective Ovariohysterectomy

Total Intravenous Anesthesia With Propofol Associated or Not With Remifentanil, Ketamine, or S-Ketamine for Laparoscopic Ovariectomy in Female Dogs

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