Anatomic and metabolic risk factors for nephrolithiasis in patients with autosomal dominant polycystic kidney disease

Grampsas, Samuel A.; Chandhoke, Paramjit S.; Fan, Jie; Glass, Michael A.; Townsend, Ronald R.; Johnson, Ann; Gabow, Patricia A.

doi:10.1053/ajkd.2000.8266

Cited by 102 publications

(68 citation statements)

References 19 publications

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“…The reasons for a higher percentage of hyperoxaluria and the lack of hypercalciuria in this sample, as in other series (2) as well, are not clear. The high percentage of hypocitraturia in ADPKD here depicted was described by other authors (2,20) and also remains unexplained. It was not related to dRTA, because only 9.5% of all patients with ADPKD in this series had incomplete or complete forms of dRTA.…”

Section: Discussionsupporting

confidence: 73%

“…Although such a finding could predispose to the formation of uric acid stones, as suggested in other series (4), only three patients from this sample had voided calculi in the past, but such stones were no longer available for analysis. Anyway, because the occurrence of hypocitraturia is undeniable in the ADPKD setting (2,20), alkalinization with potassium citrate might be useful in the prevention of uric acid stones and to reduce calcium oxalate supersaturation.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Nephrolithiasis in Autosomal Dominant Polycystic Kidney Disease Patients

Nishiura¹,

Neves²,

Eloi³

et al. 2009

Clinical Journal of the American Society of Nephrology

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Background and objectives: Nephrolithiasis (LIT) is more prevalent in patients with autosomal dominant polycystic kidney disease (ADPKD) than in the general population. Renal ultrasonography may underdetect renal stones because of difficulties imposed by parenchymal and/or cyst wall calcifications.Design, setting, participants, & measurements: A total of 125 patients with ADPKD underwent ultrasonography and unenhanced computed tomography (CT) scan, routine blood chemistry, and spot and 24-h urine collections.Results: CT scan detected calculi in 32 patients, including 20 whose previous ultrasonography revealed no calculi. The percentage of hypocitraturia was high but not statistically different between patients with ADPKD؉LIT or ADPKD. Hyperuricosuria and distal renal tubular acidosis were less prevalent but also did not differ between groups, whereas hyperoxaluria was significantly higher in the former. Hypercalciuria was not detected. Renal volume was significantly higher in patients with ADPKD؉LIT versus ADPKD, and a stepwise multivariate logistic regression analysis showed that a renal volume >500 ml was a significant predictor of LIT in patients with ADPKD and normal renal function, after adjustments for age and hypertension.Conclusions: CT scan was better than ultrasonography to detect LIT in patients with ADPKD. Larger kidneys from patients with ADPKD were more prone to develop stones, irrespective of the presence of metabolic disturbances.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Evaluation of Nephrolithiasis in Autosomal Dominant Polycystic Kidney Disease Patients

Nishiura¹,

Neves²,

Eloi³

et al. 2009

Clinical Journal of the American Society of Nephrology

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“…Chemical analyses demonstrated that calcium oxalate is the most common component found in kidney stones 39 . Calcium oxalate calculi were also found in 85.7% of the cases in this study.…”

Section: Discussionmentioning

confidence: 99%

Investigação de nefrolitíase no Oeste do Paraná

Peres¹,

Almeida²,

Bolson³

et al. 2011

J. Bras. Nefrol.

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ResumoIntrodução: Nefrolitíase é comum e tem alta taxa de recorrência. Objetivos: Avaliar a prevalência das principais alterações metabólicas e anatômicas e a análise química do cálculo encontrado em pacientes com nefrolitíase na região Oeste do Paraná. Métodos: Foi realizado um estudo retrospectivo em 681 pacientes adultos com nefrolitíase. A investigação laboratorial incluiu pelo menos duas amostras de urina de 24 horas, com dosagens de cálcio, ácido úrico, citrato, oxalato, sódio e creatinina; cistinúria qualitativa, pH urinário após 12 horas de jejum e restrição hídrica, urocultura e análise química do cálculo, quando disponível. Técnicas de imagem renal incluíram pelo menos ultrassonografia e urografia excretora. Resultados: As alterações metabólicas mais frequentemente encontradas foram: hipercalciúria (51,8%), hiperuricosúria (27,6%) e hipocitratúria (23,5%). A análise química dos cálculos mostrou oxalato de cálcio em 85,7% dos casos. As alterações anatô-micas mais frequentes foram: cisto renal, duplicação pieloureteral e obstrução da junção pieloureteral. Conclusões: Este trabalho serviu de base para o conhecimento das características de pacientes com nefrolitíase na região Oeste do Paraná. Palavras-chave: nefrolitíase, hipercalciúria, oxalato de cálcio. AbstRActIntroduction: Nephrolithiasis is common and has a high rate of recurrence. Objectives: To assess the prevalence of the main metabolic and anatomical changes and the chemical analysis of stone found in patients with nephrolithiasis in the West region of Paraná. Methods: Retrospective study with 681 adult patients with nephrolithiasis. The laboratory investigation included at least two samples of 24-hour urine test with doses of calcium, uric acid, citrate, oxalate, sodium and creatinine; qualitative cystinuria, urinary pH following 12-hour fast and water restriction, urine culture and chemical analysis, when the stones were available. Renal imaging techniques included at least renal ultrasound and excretory urogram. Results: The metabolic changes most frequently found were: hypercalciuria (51.8%), hyperuricosuria (27.6%), and hypocitraturia (23.5%). Chemical analysis of stones showed calcium oxa late in 85.7% of the cases. The most frequently anatomical changes were renal cyst, duplicated ureter, and ureteropelvic junction obstruction. Conclusions: This paper served as a base for knowing the characteristics of patients with nephrolithiasis in the West area of Paraná.

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“…Anatomical factors such as increased renal volume and several metabolic impairments including low urine Ph and volume, hypocitraturia, hyperoxaluria, hyperuricosuria, hypomagnesemia, and possible distal acidification defects contribute to the development of renal stones (3,(5)(6)(7) . Furthermore, other risk factors including body mass index (BMI), hypertension (HT), education level, hepatic cysts and age, were mentioned as risk factors for stone formation in previous studies (8) .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Nephrolithiasis Risk Factors in Autosomal Dominant Polycystic Kidney Disease (ADPKD): A Single Center Experience

Kaygısız¹,

Çoşkun²,

Oruç³

et al. 2017

Okmeydani Medical Journal

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Anatomic and metabolic risk factors for nephrolithiasis in patients with autosomal dominant polycystic kidney disease

Cited by 102 publications

References 19 publications

Evaluation of Nephrolithiasis in Autosomal Dominant Polycystic Kidney Disease Patients

Evaluation of Nephrolithiasis in Autosomal Dominant Polycystic Kidney Disease Patients

Investigação de nefrolitíase no Oeste do Paraná

Evaluation of Nephrolithiasis Risk Factors in Autosomal Dominant Polycystic Kidney Disease (ADPKD): A Single Center Experience

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