Anaplastic Colon Carcinoma Associated with Necrotizing Vasculitis

Paajanen, Hannu; Heikkinen, Markku; Tarvainen, Riitta; Vornanen, Marline; Pääkkönen, Matti

doi:10.1097/00004836-199509000-00021

Cited by 7 publications

(3 citation statements)

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“…Among them, four cases have been reported to have vasculitis in the adjacent tissue of the solid tumor. 11–14 Cutaneous leukocytoclastic vasculitis and nerve and muscle microvasculitis were the most frequently observed vasculitic subtypes. 15 The unique distribution of vasculitis in this case is uncommon.…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic vasculitis associated with esophageal carcinoma

Mita¹,

Nakanishi²,

Ochiai³

et al. 1999

Pathology International

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We report a case of esophageal carcinoma associated with paraneoplastic vasculitis. A 69-year-old man suffered from low-grade fever and numbness of the lower limbs for 3 months before esophageal and gastric carcinomas were detected. Concurrent infection or collagen disease was ruled out following clinical and laboratory examinations. In April 1996, the gastric carcinoma was completely removed by endoscopic mucosal resection, but the symptoms remained. Three weeks later esophagectomy was performed for esophageal carcinoma after which time the fever and numbness disappeared. The esophageal carcinoma was a well-differentiated squamous cell carcinoma invading into the submucosal layer. Twenty-two lymph node metastases were found in 68 resected lymph nodes. Latent thyroid cancer was found. Histologically, vasculitis was detected in the esophagus, stomach and serratus anterior muscle. The distribution and degree of vasculitis were most pronounced in the esophagus. The concurrent onset and spontaneous resolution of fever and numbness after the removal of the esophageal carcinoma suggested a paraneoplastic origin. The majority of patients with malignant neoplasm-associated vasculitis had hematologic neoplasms. Cases of esophageal carcinoma associated with paraneoplastic vasculitis are extremely rare.

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Section: Discussionmentioning

confidence: 99%

Paraneoplastic vasculitis associated with esophageal carcinoma

Mita¹,

Nakanishi²,

Ochiai³

et al. 1999

Pathology International

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“…During the past 25 years, several distinct morphologic variants of colorectal carcinoma (CRC) have been identified, including such patterns as mucinous (colloid) carcinoma, 1 signet-ring cell adenocarcinoma, 2 "anaplastic" large-cell carcinoma, 3,4 neuroendocrine carcinoma, 5 "amphicrine" carcinoma, 6 sarcomatoid carcinoma ("carcinosarcoma"), 7 squamous cell carcinoma, 8 lymphoepithelioma-like carcinoma, 9 and "medullary" (undifferentiated) carcinoma. 10,11 Aside from having clinical evolutions that are potentially different from those of conventional forms of CRC, these other morphotypes also evoke dissimilar differential diagnoses and raise various questions about correlations between their histologic images and basic cellular properties.…”

Section: Introductionmentioning

confidence: 99%

Sporadic Medullary Carcinoma of the Colon

et al. 2005

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We studied 68 sporadic colorectal carcinomas (CRCs) with medullary features (MCRCs) and compared them with 35 poorly differentiated purely "enteric" CRCs (ECRCs) and 15 purely neuroendocrine carcinomas (NECs) of grades II and III, all in patients lacking a family history of CRC. Potential clinicopathologic differences between the study groups were assessed. MCRCs were significantly more common in the ascending colon than were ECRCs, but there was no significant dissimilarity to NECs. ECRCs occurred more often in the rectosigmoid than MCRCs or NECs. MCRCs arose in older patients, and a marked sex difference also was noted. Despite an infiltrative growth pattern, MCRC was less likely than ECRC to manifest with stage III or IV disease, but there was no stage-related difference from NECs. Although the histologic images of MCRCs were evocative of neuroendocrine differentiation, chromogranin positivity and synaptophysin reactivity in that group did not differ meaningfully from that of ECRCs but was dissimilar to the 100% labeling of NECs. p53 immunolabeling was similar in the 3 tumor groups. Follow-up data in the study cases showed that 5-year mortality was 40% (27/68) for MCRC, 59% (19/32) for ECRC, and 93% (14/15) for NEC. Medullary CRC seems to be a distinct clinicopathologic variant of CRC, which does not have a neuroendocrine lineage. The biologic behavior of MCRC was better than that of ECRC or NEC.

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“…Sarcomatoid/anaplastic carcinomas of the intestine (8, 9) have rarely been described in the literature. In particular, those of the colonic primary are extremely rare (10,11). Anaplastic carcinoma of the colon and rectum, first reported as 'small-cell carcinoma', comprises approximately 0.2 to 0.4% of all malignancies in these regions and those anaplastic carcinomas had a neuroendocrine cell component based on the positive Grimelius and anti-NSE stainings, and specific dense-cored neurosecretory granules revealed by electron microscopy (EM) (12).…”

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confidence: 99%