Paraneoplastic vasculitis associated with esophageal carcinoma

Vasculitis is defined as inflammation of blood vessels and can affect multiple organs. Several classification systems exist to categorize vasculitis such as vessel size, presence of anti-neutrophil cytoplasmic antibody, pathogenesis of the inflammation, and type of inflammatory cell infiltrate. Cutaneous vasculitis occurs as a manifestation of many diseases including rheumatologic diseases, hypersensitivity syndromes, infections, and malignancies. The diagnosis of the cutaneous vasculitis and the underlying cause requires a complete history and physical exam and usually a biopsy or angiogram. The treatment depends on the etiology of the inflammation and includes immunosuppression, withdrawal of the offending agent, antibacterial/antiviral agents, and chemotherapies. A clear understanding and approach to this condition will improve the physician's ability to provide optimal patient care.

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“…Their clinical and histopathologic manifestations, however, are very similar to the most common types, already described [26,27,28].…”

Section: Miscellaneoussupporting

confidence: 57%

Cutaneous vasculitis

Hayat¹,

Berney

2005

Curr Rheumatol Rep

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“…After esophagectomy, the fever and numbness disappeared, which suggested a paraneoplastic origin. The histopathologic result confirmed the diagnosis of vasculitis [22].…”

Section: Esophageal Cancersupporting

confidence: 56%

“…The most common sites of metastasis of the gastric cancer are the liver and the peritoneum, but also kidney, bladder, brain, bone, heart, thyroid, adrenal glands and skin [22]. The presence of Virchow's node suggests gastric cancer's spread to the left supraclavicular lymph node, while Sister Mary Joseph's nodule (a periumbilical nodule) indicates metastasis in the periumbilical area.…”

Section: Gastric Cancermentioning

confidence: 99%

Paraneoplastic syndromes in digestive tumors: a review

Draghici¹,

Negreanu²,

Bratu³

et al. 2019

Rom Biotechnol Lett.

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Paraneoplastic syndromes are disorders induced by the altered immune response to a malignant tumor, which secretes hormones, peptides, or cytokines. The clinical manifestations of the paraneoplastic syndromes are the consequence of the substances produced by the tumor and may affect various organs and systems, being classified in endocrine, neurologic, dermatologic, rheumatologic and hematologic syndromes. These syndromes are most commonly associated with malignancies like small cell lung cancer, breast cancer, gynecologic tumors and hematologic malignancies. Paraneoplastic syndromes may be the first or most obvious manifestation of a neoplasia; if they occur in a patient without a known cancer, they should be carefully investigated. In this regard, they may reveal early a clinically ocult tumor, in a highly treatable stage. The incidence and prevalence of digestive tumors is increasing. Therefore, in order to ensure proper treatment and longer survival, an early diagnosis is necessary. Gastrointestinal cancers are often accompanied by paraneoplastic syndromes, which sometimes may be the "clue" for the diagnosis of cancer. In digestive malignant neoplasms, paraneoplastic dermatologic syndromes are the most common. The evolution of patients with paraneoplastic syndromes depends on patient's comorbidities and complications. If the malignancy is successfully treated, the paraneoplastic syndromes will evolve favorably.

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“…The combination of the above-described symptomsis referred to collectively as paraneoplastic syndrome (2). The majority of patients with neoplasm-associated vasculitis had a hematologic malignancy (3). Weherein report a rare case of polyarteritis associated with a solid tumor.…”

Section: Introductionmentioning

confidence: 95%

Polyarteritis Associated with Hypopharyngeal Carcinoma.

et al. 2002

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A rare case of polyarteritis associated with a solid tumoris presented. A 66-year-old manwas referred to our hospital, because of gangrene in the bilateral fingers and toes, right pleural effusion, and an abnormal sensation in the throat. Adiagnosis of polyarteritis was madebased on pleuritis, digital gangrene and the arteriography findings. He also had a hypopharyngeal carcinoma. After being treated with intermittent intravenous cyclophosphamide, oral corticosteroid, alprostadil and aspirin, the pleural effusion rapidly disappeared, while the digital gangrene gradually improved. For the treatment of hypopharyngeal carcinoma, radiation therapy was initiated and resulted in complete disappearance. (Internal Medicine 41: 892-895, 2002)

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Paraneoplastic vasculitis associated with esophageal carcinoma

Cited by 16 publications

References 10 publications

Cutaneous vasculitis

Cutaneous vasculitis

Paraneoplastic syndromes in digestive tumors: a review

Polyarteritis Associated with Hypopharyngeal Carcinoma.

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