Sarcomatoid Carcinoma of the Descending Colon: A Histological, Immunohistochemical and Ultrastructural Analysis

Shoji, Mitsuhiko; Dobashi, Yoh; Iwabuchi, Kazuya; Kuwao, Sadahito; Mikami, Taisei; Kameya, Toru

doi:10.1080/028418698430179

Cited by 24 publications

(12 citation statements)

References 14 publications

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“…To date, our search by computer (MED-LINE search) revealed only six cases of the colonic sarcomatoid carcinomas reported (1)(2)(3)(4)(5)(6). As a result, the natural history of these unusual tumors and the best methods of treatment thereof are uncertain.…”

Section: Introductionmentioning

confidence: 99%

Sarcomatoid Carcinoma of the Colon: A Case Report

et al. 2001

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Sarcomatoid carcinoma is a rare biphasic tumor characterized by a combination of malignant epithelial and mesenchymal cells. We report a rare case of sarcomatoid carcinoma of the colon. A 41-yr-old woman was hospitalized with a history of melena. Total colectomy was performed under the impression of colonic carcinoma. Histologically, the tumor was composed of differentiated adenocarcinoma in superficial portion and sarcomatoid spindle cells in deeper portion with a transitional area between the two portions. The sarcomatous areas revealed polygonal and spindle-shaped anaplastic malignant cells arranged in sheet, short fascicular or haphazard pattern. Immunohistochemically, tumor cells showed a positive immunoreaction for cytokeratin, epithelial membrane antigen, and vimentin. The histopathological and immunohistochemical transitions between the adenocarcinoma area and the spindle cell area suggested that the sarcomatous elements originated from the adenocarcinoma during tumor progression.

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Section: Introductionmentioning

confidence: 99%

Sarcomatoid Carcinoma of the Colon: A Case Report

et al. 2001

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“…In this patient, heterologous differentiation of osteo- and chondrosarcomatous areas was observed in the mesenchymal component. With regard to chemotherapy, 5-FU FL therapy (UFT+leucovorin), and capecitabine, or MMC, cisplatin have been administered to patients with metastasis in lymph nodes in accordance with colon cancer therapy, but a satisfactory treatment effect has not been obtained as yet [1, 6, 8, 12, 13, 18]. This patient had been orally administered capecitabine as postoperative adjuvant chemotherapy, but multiple lung metastases were observed by PET examination conducted 6 months after surgery.…”

Section: Discussionmentioning

confidence: 99%

Carcinosarcoma of the Sigmoid Colon: Report of a Case

Mori

Katsumata

Suzuki

et al. 2010

Case Rep Gastroenterol

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Our case was a 65-year-old male, with the chief complaints of diarrhea and abdominal distention. Three years earlier, the patient had undergone transcatheter arterial embolization and radiofrequency treatment based on a diagnosis of hepatocellular carcinoma due to hepatitis B by another doctor. In October 2007, the patient developed diarrhea and increased abdominal distention. In December, CT examination conducted by the previous doctor revealed a 20-cm tumor within the pelvis. The patient was diagnosed with sigmoid colon cancer based on barium enema examination using gastrografin, and was introduced to our hospital for treatment. He was diagnosed with low-differentiated carcinoma by biopsy of the colon during endoscopy and underwent sigmoidectomy based on a diagnosis of sigmoid colon cancer. The tumor had infiltrated the bladder, and a tumorectomy was conducted through partially combined resection. The tumor was a huge lesion occupying the inside of the lumen, and histopathological findings revealed that the tumor, the main part of which lay beneath the mucous membrane, had a transitional image composed of both spindle-shaped atypical cells and sarcomatoid shape. The result of immunostaining was CK7(+), CK20(–), AFP(–), and the patient was diagnosed as having carcinosarcoma of the colon. Carcinosarcoma of the colon is a malignant tumor with poor prognosis, and the mean survival period in past reports was approximately 6 months. The patient was treated with FOLFIRI+Bevacizumab therapy according to chemotherapy for colon cancer, but he was refractory to the therapy.

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“…Other authors used terms like Sarcomatoid carcinoma, Carcinosarcoma, metaplastic [3] carcinoma and spindle cell carcinoma. [6] except for cytokeratin immunoreactivity. The neoplasm primarily affects middle aged to older patients with a mean [3] age of 57 years at presentation.…”

Section: Introductionmentioning

confidence: 98%

Aggressive Monophasic Sarcomatoid Carcinoma of Small Intestine - A Rare Case Report With Review of Literature

Padma¹,

Permi²,

Patil³

et al. 2012

Journal of Health and Allied Sciences NU

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Sarcomatoid carcinoma occurring in the small intestine is very rare. They can be monophasic or biphasic. We report a rare case of monophasic Sarcomatoid carcinoma of the small intestine in a 60 year old male patient. The tumor was an ulceronodular mass involving the ileum circumferentially. The tumor infiltrated the full thickness of the intestinal wall and the serosa of an adjacent loop of ileum. Microscopically, the tumor was composed of sheets of malignant spindle cells. The carcinomatous nature of the tumor was evident only after Immunohistochemistry. The diagnosis of sarcomatoid carcinoma should be considered in the differential diagnosis of malignant spindle cell tumor of small intestine and immunohistochemical stains are required for the correct diagnosis.

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Sarcomatoid Carcinoma of the Descending Colon: A Histological, Immunohistochemical and Ultrastructural Analysis

Cited by 24 publications

References 14 publications

Sarcomatoid Carcinoma of the Colon: A Case Report

Sarcomatoid Carcinoma of the Colon: A Case Report

Carcinosarcoma of the Sigmoid Colon: Report of a Case

Aggressive Monophasic Sarcomatoid Carcinoma of Small Intestine - A Rare Case Report With Review of Literature

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