Anaphylaxis to streptomycin

Romano, Antonino; Viola, Marinella; Fonso, M. Di; Perrone, M. R.; Gaeta, Francesco; Andriolo, Mario

doi:10.1034/j.1398-9995.2002.23836_9.x

Cited by 21 publications

(5 citation statements)

References 4 publications

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“…Other cutaneous manifestations like urticaria, maculopapular rash, fixed drug eruption and TEN have been reported [103,104]. Anaphylaxis to aminoglycosides is very uncommon [105,106,107]. Desensitization is possible for IV (Supplementary Materials Table S7 in the Supplementary) and inhaled tobramycin, as well as those with urticaria or angioedema due to streptomycin [108,109,110].…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial Desensitization: A Review of Published Protocols

et al. 2019

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Antimicrobial desensitization represents a last-line option for patients with no alternative therapies, where the benefits of this intensive process must outweigh the potential harm from drug exposure. The goal of antimicrobial desensitization procedures is to establish a temporary state of tolerance to drugs that may otherwise cause hypersensitivity reactions. While no universal antimicrobial desensitization protocols exist, this review critically analyzes previously published desensitization protocols. The purpose of this review is to provide a greater insight for clinicians and institutions to ensure desensitization procedures are efficacious while minimizing potential for patient harm. With an increasing rate of antimicrobial resistance and the critical need to preserve antimicrobial agents, desensitization may represent another option in our antimicrobial stewardship toolkit.

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Section: Resultsmentioning

confidence: 99%

Antimicrobial Desensitization: A Review of Published Protocols

et al. 2019

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“…Two cases of anaphylaxis to SPT with 1 mg/ml streptomycin concentration have been described. Thus, it has been suggested to start with concentrations of 0.1–1 ng/ml and gradually increase the concentration up to 20 mg/ml .However, the irritant properties of the highest concentrations have not been evaluated, and it is not known whether a densitization would occur with such a protocol. For delayed HSRs to aminoglycosides, patch tests have been performed (Table S3).…”

Section: Aminoglycosidesmentioning

confidence: 99%

Hypersensitivity reactions to non‐betalactam antibiotics in children: An extensive review

Kuyucu

Mori

Atanasković-Marković

et al. 2014

Pediatric Allergy Immunology

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In contrast to hypersensitivity reactions (HSRs) to β-lactam antibiotics in children, studies about HSR to non-β-lactam antibiotics (NBLAs) such as sulfonamides, macrolides, quinolones, and antituberculosis agents are scarce, and information is generally limited to case reports. The aim of this extensive review was to summarize our present knowledge on clinical characteristics, evaluation, and management of HSR to NBLAs in children based on the literature published between 1980 and 2013. NBLAs have been reported to induce a wide spectrum of HSRs from mild eruptions to severe, and sometimes fatal, systemic drug reactions, especially in some high-risk groups. The diagnosis relied upon history and remained unconfirmed by allergological tests in most of the cases. Obtaining a detailed history is valuable in the diagnosis of suspected reactions to NBLAs. Diagnostic in vivo and in vitro tests for NBLAs lack validation, which makes the diagnosis challenging. The definitive diagnosis of NBLA hypersensitivity frequently depends upon drug provocation tests. Studies including children showed that only 7.8 to 36% of suspected immediate and delayed HSRs to NBLAs could be confirmed by skin and/or provocation tests. Therefore, a standardized diagnostic approach and management strategy should be developed and employed for pediatric patients in the evaluation of suspected HSRs to NBLAs, some of which may be critical and unreplaceable in certain clinical situations.

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“…As reported recently, a patient developed a drug reaction with eosinophilia and systemic syndrome (DiHS, DRESS) induced by amikacin used for the treatment of septic arthritis of the knee, which was confirmed by patch tests and immunobiologic tests. Cross-reactivity with other aminoglycosides was not observed in this patient [ 25 ].…”

Section: Aminoglycosidesmentioning

confidence: 99%

“…Few anaphylactic reactions to streptomycin have been reported in which the drug was present in contaminated food, or added to cell culture media and administered during in vitro fertilization, or during immunotherapy with phytohemagglutinin-lymphokine-activated killer cells, or absorbed through skin lesions of a subject affected by hand allergic contact dermatitis. In most of these reactions an IgE-mediated mechanism was suspected on the basis of skin-test positivity [ 25 ]. Gentamicin-induced anaphylaxis is rarely reported.…”

Section: Aminoglycosidesmentioning

confidence: 99%

Hypersensitivity reactions to non beta-lactam antimicrobial agents, a statement of the WAO special committee on drug allergy

Sánchez‐Borges

Thong

Blanca

et al. 2013

World Allergy Organization Journal

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Antibiotics are used extensively in the treatment of various infections. Consequently, they can be considered among the most important agents involved in adverse reactions to drugs, including both allergic and non-allergic drug hypersensitivity [J Allergy Clin Immunol 113:832–836, 2004]. Most studies published to date deal mainly with reactions to the beta-lactam group, and information on hypersensitivity to each of the other antimicrobial agents is scarce. The present document has been produced by the Special Committee on Drug Allergy of the World Allergy Organization to present the most relevant information on the incidence, clinical manifestations, diagnosis, possible mechanisms, and management of hypersensitivity reactions to non beta-lactam antimicrobials for use by practitioners worldwide.

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Anaphylaxis to streptomycin

Cited by 21 publications

References 4 publications

Antimicrobial Desensitization: A Review of Published Protocols

Antimicrobial Desensitization: A Review of Published Protocols

Hypersensitivity reactions to non‐betalactam antibiotics in children: An extensive review

Hypersensitivity reactions to non beta-lactam antimicrobial agents, a statement of the WAO special committee on drug allergy

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