Analyzing the adhesion mechanism of FnBPA, a surface adhesin from Staphylococcus aureus on its interaction with nanoparticle

Ponnuvel, Shobana; Sankar, Sreejanani; Ponnuraj, Karthe

doi:10.1016/j.micpath.2020.104239

Cited by 5 publications

(6 citation statements)

References 39 publications

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“…In the structure of their walls, staphylococci possess proteins (FnBPA -fibronectin-bindin protein A) that have a role in the adhesion process, but Fn-BPA also has a variable affinity for fibrinogen [2]. In addition to proteins such as FnBPA, coagulase also acts to bind fibrinogen.…”

Section: Discussion Of the Problemmentioning

confidence: 99%

Properties of coagulase-positive staphylococcal cells that make it difficult to diagnose and treat mastitis in cows

Grzeczka

Niewitecki

2021

Medical Journal of Cell Biology

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Coagulase-positive staphylococci are a group of bacteria that, among other things, cause inflammation of the udder in cows (mastitis). The identification of the species of staphylococcus causing the inflammation is crucial for the success of the treatment process due to the individual characteristics of the strains and even the characteristics of the bacterial population in the herd. However, through evolution, staphylococci have developed a number of processes that make species identification difficult. Knowledge of the actual cause of inflammation enables the selection of appropriate therapy, but despite advanced diagnostic techniques, erroneous results still occur. In this review, we present the current knowledge of mainly resistance mechanisms and how they affect the drug resistance of microorganisms. We also highlight the difficulties in the diagnosis and treatment of bovine mastitis.

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Section: Discussion Of the Problemmentioning

confidence: 99%

Properties of coagulase-positive staphylococcal cells that make it difficult to diagnose and treat mastitis in cows

Grzeczka

Niewitecki

2021

Medical Journal of Cell Biology

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“…These devices generally present a 5% failure rate, with most cases attributed to the bacterial colonization of biomaterial surfaces, formation of biofilms and spread into adjacent tissues [85,86,[90][91][92][93]. S. aureus, for example, recognizes host extracellular matrix (ECM) molecules and initiates colonization of the epithelium through microbial surface recognizing adhesive matrix molecules (MSCRAMMs), such as fibronectin binding protein A (FnBPA) [92]. In contrast, NPs interfere with the function and binding property of FnBPA, enabling their use in a wide variety of biomedical applications [92].…”

Section: Application Of Nanotechnology In Biofilms In Biomaterials Implantsmentioning

confidence: 99%

“…S. aureus, for example, recognizes host extracellular matrix (ECM) molecules and initiates colonization of the epithelium through microbial surface recognizing adhesive matrix molecules (MSCRAMMs), such as fibronectin binding protein A (FnBPA) [92]. In contrast, NPs interfere with the function and binding property of FnBPA, enabling their use in a wide variety of biomedical applications [92]. Similarly, 316L stainless steel coated with a polyelectrolyte multilayer and a mesoporous bioactive glass exhibited controlled antibiotic (tetracycline) release and biocompatibility, showing great potential in endowing orthopedic implants with antibacterial and osteoconductive properties [93].…”

Section: Application Of Nanotechnology In Biofilms In Biomaterials Implantsmentioning

confidence: 99%

Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases

et al. 2021

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Bacteria-targeting nanomaterials have been widely used in the diagnosis and treatment of bacterial infectious diseases. These nanomaterials show great potential as antimicrobial agents due to their broad-spectrum antibacterial capacity and relatively low toxicity. Recently, nanomaterials have improved the accurate detection of pathogens, provided therapeutic strategies against nosocomial infections and facilitated the delivery of antigenic protein vaccines that induce humoral and cellular immunity. Biomaterial implants, which have traditionally been hindered by bacterial colonization, benefit from their ability to prevent bacteria from forming biofilms and spreading into adjacent tissues. Wound repair is improving in terms of both the function and prevention of bacterial infection, as we tailor nanomaterials to their needs, select encapsulation methods and materials, incorporate activation systems and add immune-activating adjuvants. Recent years have produced numerous advances in their antibacterial applications, but even further expansion in the diagnosis and treatment of infectious diseases is expected in the future.

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“…Among various pathogenicity factors, surface adhesions, typically known as MSCRAMMs (microbial surface components recognizing adhesive matrix molecules) are of vital importance due to their role in appropriate colonization and bio lm formation [4,5]. The family of MSCRAMMs consisting of fnbA and fnbB ( bronectin-binding protein A and B), clfA, clfB (clumping factor A and B), cna (collagen adhesin), bbp (sialoprotein-binding protein), ebpS (elastin-binding protein of S. aureus), spa (Staphylococcal protein A), map/eap (extra-cellular adhesion protein), sdrC, sdrD, and sdrE (serine aspartate repeat proteins C, D, and E) genes [4,6,7].…”

Section: Introductionmentioning

confidence: 99%

The prevalence and comparative analysis of adhesion and biofilm-related genes in Staphylococcus aureus isolates: A network meta-analysis

Sharifi,

Mahmoudi,

Sobhani

2023

Preprint

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Background: Staphylococcus aureus is a versatile pathogen capable of causing a wide range of infections, from minor skin infections to life-threatening invasive diseases. The pathogenicity of S. aureus is attributed to its ability to produce various virulence factors, including adhesion and biofilm-related proteins. Methods: In this study, we conducted a comprehensive network meta-analysis to assess the prevalence of adhesion and biofilm-related genes in S. aureus isolates and investigate the impact of the isolate source on their occurrence. Results: A total of 53 relevant studies were included. The highest prevalence were observed for clfB (p-estimate = 85.4), followed by eno (p-estimate = 81.1) and icaD (p-estimate = 77). Conversely, bap and bbp exhibited the lowest prevalence (p-estimate = 6.7 and 18.7, respectively). The most frequently co-studied gene pairs were icaA-icaD(30 times) and fnbA-fnbB (25 times). Based on subgroup analysis the occurrence of icaC and icaB was significantly lower in animal isolates compared to human and food. Conclusion: The study revealed varying prevalence rates of adhesion and biofilm-related genes in S. aureus isolates. Our results contribute to a better understanding of S. aureus pathogenesis and can facilitate the development of effective strategies for the prevention and treatment of S. aureus infections.

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Analyzing the adhesion mechanism of FnBPA, a surface adhesin from Staphylococcus aureus on its interaction with nanoparticle

Cited by 5 publications

References 39 publications

Properties of coagulase-positive staphylococcal cells that make it difficult to diagnose and treat mastitis in cows

Properties of coagulase-positive staphylococcal cells that make it difficult to diagnose and treat mastitis in cows

Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases

The prevalence and comparative analysis of adhesion and biofilm-related genes in Staphylococcus aureus isolates: A network meta-analysis

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