Analytical Properties of 2-, and 10-Disubstituted Phenothiazine Derivatives

Karpińska, Joanna; Starczewska, Barbara; Puzanowska-Tarasiewicz, Helena

doi:10.2116/analsci.12.161

Cited by 92 publications

(66 citation statements)

References 39 publications

(4 reference statements)

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“…14 Phenothiazines were also used as spectrophotometric reagents 2,8 and indicators in various redox titrations with K2Cr2O7, Ce(SO4)2, NH4VO3, KBrO3. 1,3,15 In the presented paper the applications of some oxidizing agents for the spectrophotometric and flow-injection determination of 2,10-disubstituted phenothiazines have been described. with the formation of colored oxidation products.…”

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confidence: 99%

Efficient Oxidizing Agents for Determination of 2,10-Disubstituted Phenothiazines

Puzanowska-Tarasiewicz

Kuźmicka

Karpińska

et al. 2005

ANAL. SCI.

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confidence: 99%

Efficient Oxidizing Agents for Determination of 2,10-Disubstituted Phenothiazines

Puzanowska-Tarasiewicz

Kuźmicka

Karpińska

et al. 2005

ANAL. SCI.

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“…39 Perphenazine was oxidized in acidic media to form a red free radical, which was further oxidized to a colorless product instantly. 40,41 As discussed above, surfactants would 302 ANALYTICAL SCIENCES FEBRUARY 2006, VOL. 22 a.…”

Section: Influence Of Surfactants On the Systemmentioning

confidence: 98%

A Kinetic Spectrophotometric Method for the Determination of Nitrite by Stopped-Flow Technique

Wang

Gao

2006

ANAL. SCI.

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A novel and highly sensitive stopped-flow kinetic spectrophotometric method for the determination of nitrite, based on monitoring the variation in the absorbance of the intermediate within a very short period, has been developed. The optimum conditions for various parameters on which the reaction of nitrite with perphenazine depends, were investigated. It was found that the initial reaction rate increased linearly with increasing nitrite concentration in the range from 1.0 × 10 -8 to 6.0 × 10 -6 M. The detection limit was calculated to be 4.8 × 10 -9 M. This method was used for the determination of nitrite in natural and drinking-water with satisfactory results. The influence of cationic, non-ionic and anion surfactants was also studied in this work.

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“…It is also used for the relief of nausea and vomiting, pre-operative anxiety, and intractable hiccups. Chlorpromazine is very sensitive to light and easily darkens when exposed to light [1,2].…”

Section: Introductionmentioning

confidence: 99%

Method Development and Validation of Assay of Chlorpromazine Hydrochloride Tablet Formulation Using Ultra Violet Visible Spectrophotometry

Shatti¹

2014

J Anal Bioanal Tech

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The International Conference on Harmonisation [Q2 (R1)] guidelines was applied for this one-step spectrophotometric estimation of chlorpromazine hydrochloride in neurazine tablet formulation. The method was found to be simple, safe, sensitive, and validated for the assay of chlorpromazine hydrochloride using bromophenol blue, citrate buffer pH 3, and water as diluents. It was also found to be an accurate, reproducible, and cost-effective quality-control tool for the routine analysis of chlorpromazine hydrochloride in standard and pharmaceutical forms. Method Development and Validation of Assay of Chlorpromazine Hydrochloride Tablet Formulation Using Ultra Violet Visible SpectrophotometryLaila A Al Shatti* Diluent preparationDistilled water was used as a diluent. Standard preparationA bromophenol blue (1×10 -3 M) and Cpn-HCl (1×10 -3 M) stock solution was prepared to be used for the preparation of standard solutions. In 100 mL volumetric flasks, 15 mL BrPB, 3 mL citrate buffer (pH 3), and different aliquots of Cpn-HCl (1×10 -3 M) were added to prepare five standard solutions of Cpn-HCl ranging in concentration from 2.553-16 ppm. The five standard solutions were scanned for the maximum wavelength (nm) previously assigned, and a calibration curve was set to perform the linearity test. Pharmaceutical test preparationTen tablets of neurazine formulation were ground and weighed (4.4870 g). Each tablet contained 100 mg active ingredient of Cpn-HCl. To prepare the stock solution (1×10 -3 ) of the formulation, 0.1594 g of the ground tablets were weighed and dissolved with distilled water in a 100 mL volumetric flask. The stock solution was diluted to prepare (1×10 -4 M). A test solution was made by adding 15 mL bromophenol blue, 3 mL citrate buffer (pH 3), and 10 mL neurazine (1×10 -4 M) (ppm). The solution was tested by the extrapolation method to determine the concentration of the neurazine test sample. InstrumentationA UV-visible double beam spectrophotometer with matched quartz cell (1 cm) (model no. Evolution 201) by Thermo Scientific, 81 Wyman Street Waltham, Massachusetts, US was used. Results and Discussion Development and optimization of the spectrophotometric methodThe selection of the proper wavelength in this method depends on the sample, diluent, and test solution. Spectrophotometric quantitative determination of chlorpromazine needs the development of rugged and suitable conditions after testing different parameters, such as diluents, buffer, buffer concentration, and other chromatographic conditions. Different trials with varied compositions of diluents and buffer should be conducted to choose the optimum conditions. Selection of wavelengthThe standard solution and the pharmaceutical test forms were scanned by UV-visible spectrophotometer between 200 and 700 nm on spectrum mode before and after using BrPB (Figures 1 and 2). Both spectra showed that Cpn-HCl has a maximum wavelength λ max at 314. Bromophenol blue was scanned to avoid the interferences of wavelengths (Figure 3). The spectrum pf BrPB ...

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Analytical Properties of 2-, and 10-Disubstituted Phenothiazine Derivatives

Abstract: Phenothiazine derivatives substituted in the 2 and 10 positions belong to a big group of tricyclic aromatic compounds.

Cited by 92 publications

References 39 publications

Efficient Oxidizing Agents for Determination of 2,10-Disubstituted Phenothiazines

Efficient Oxidizing Agents for Determination of 2,10-Disubstituted Phenothiazines

A Kinetic Spectrophotometric Method for the Determination of Nitrite by Stopped-Flow Technique

Method Development and Validation of Assay of Chlorpromazine Hydrochloride Tablet Formulation Using Ultra Violet Visible Spectrophotometry

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