Analytical methods for quantifying creatinine within biological media

Randviir, Edward P.; Banks, Craig E.

doi:10.1016/j.snb.2013.03.103

Cited by 78 publications

(56 citation statements)

References 103 publications

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“…1 Creatinine is extracted from the body by renal excretion at a relatively constant rate. 2 The variation in creatinine level in blood and urine is an important parameter in clinical diagnostics. Kidney problems, thyroid malfunction, and muscular disorders increase the creatinine concentration in blood serum, and therefore measuring the creatinine concentration in blood, serum, and urine allows diagnosis of these disorders.…”

Section: Introductionmentioning

confidence: 99%

“…3 Recently, there has been a leap forward towards manufacturing simple, accurate, and reliable biosensors to measure the amount of creatinine. [1][2][3] Normal creatinine levels in urine are in the range of 0.407 to 3.054 g L -1 in men and 0.373 to 2.545 g L -1 in women; however, they can vary according to age and gender. 2,4 In kidney malfunction, creatinine concentration can exceed 113.118 g L - 1 .…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] Normal creatinine levels in urine are in the range of 0.407 to 3.054 g L -1 in men and 0.373 to 2.545 g L -1 in women; however, they can vary according to age and gender. 2,4 In kidney malfunction, creatinine concentration can exceed 113.118 g L - 1 . Values above 15.836 g L -1 require more clinical assays and values above 59.952 g L -1 are related to kidney disease.…”

Section: Introductionmentioning

confidence: 99%

“…Values above 15.836 g L -1 require more clinical assays and values above 59.952 g L -1 are related to kidney disease. 2 Patients suffering from kidney disease need to control the creatinine concentration in their blood daily. 5 Methods to detect concentrations of creatinine have been known since at least as early as 1886, when Max Jaffe developed a colorimetric methodology to quantify creatinine within urine.…”

Section: Introductionmentioning

confidence: 99%

“…5 Methods to detect concentrations of creatinine have been known since at least as early as 1886, when Max Jaffe developed a colorimetric methodology to quantify creatinine within urine. 2 This is achieved by using potassium bichromate as an indicator, which acts as a colorimeter to elucidate the creatinine concentrations against a set of known standards. 2 The major limitation of the Jaffe reaction could be attributed to their non-specificity, and as a result, the data are largely inaccurate; biological compounds such as glucose and ascorbic acid can readily interfere with the results.…”

Section: Introductionmentioning

confidence: 99%

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A New Method for the Determination of Creatinine in Urine Samples Based on Disposable Pipette Extraction

Fernandes¹,

Souza²,

Oliveira³

et al. 2017

J. Braz. Chem. Soc.

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A method based on disposable pipette extraction (DPX) was successfully applied to creatinine determination in urine samples analysis using liquid chromatography with ultraviolet spectrophotometric detection (DPX/LC-UV). DPX variables, number of draw/eject cycles, sample pH, and type of the desorption solvent, were employed in a factorial experimental design to optimize the sorption equilibrium and time analysis. Among the evaluated DPX variables, the highest extraction efficiency was obtained with 500 µL of urine sample mixed with 1 mL of borate solution (pH 9) with one draw/eject cycle followed by liquid desorption of 1 mL of methanol in seven draw/eject cycles. The developed DPX/LC-UV method showed a linear response from the limit of quantification of 0.317 to 3.390 g L -1 with r 2 = 0.996 and inter-day precision with a coefficient of variation below 8.8%. Based on these results, the proposed method can be a useful tool for determining the creatinine levels in urine samples.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A New Method for the Determination of Creatinine in Urine Samples Based on Disposable Pipette Extraction

Fernandes¹,

Souza²,

Oliveira³

et al. 2017

J. Braz. Chem. Soc.

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Trend in creatinine determining methods: Conventional methods to molecular‐based methods

Narimani

Esmaeili

Rasta

et al. 2020

Analytical Science Advances

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Renal failure (RF) disease is ranked as one of the most prevalent diseases with severe morbidity and mortality. Early diagnosis of RF leads to subsequent control of disease to reduce the poor prognosis. The level of sera creatinine is considered as a significant biomarker for kidney biofunction, which is routinely detected by the Jaffe reaction. The normal range for creatinine in the blood may be 0.84‐1.21 mg/dL. Low accuracy, insufficient sensitivity, explosive and toxicity of picric acid, and pseudo‐interaction with nonspecific elements such as ammonium ions in the Jaffe method lead to the development of various techniques for precise detection of creatinine such as spectroscopic, electrochemical, and chromatography approaches and sensors based on enzymes, molecular imprinted polymer and nanoparticles, etc. Based on previously established results, they are trying to construct sensors with high accuracy, optimum sensitivity, acceptable linear/calibration range, and limit of detection, which are small in size and applicable by the patient him/herself (point‐of‐care testing). By comparing the results of research, a molecularly imprinted electrochemiluminescence‐based sensor with linear/calibration range of 5‐1 mM0.33emconcentration of creatinine and the detection limit of 0.5 nM has the best detectable resolution with 2 million measurable points. In this paper, we will review the recently developed methods for measuring creatinine concentration and renal biofunction.

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Determination of Creatinine in Urine by Voltammetry and Glassy Carbon Electrode Modified with Functionalized Multi‐walled Carbon Nanotubes and Copper

et al. 2022

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A square‐wave voltammetric method was developed for the determination of creatinine using glassy carbon electrode functionalized multi‐walled carbon nanotubes and doped with copper. Since the creatine‐creatinine balance is dependent on pH, the linear responses at either pH 4.0 or 7.0 were evaluated allowing versatility in application, covering analyte concentration from limit of quantification (0.3 μmol L−1) up to 1.200 μmol L−1 (pH 4) or 660 μmol L−1 (pH 7). Electrode is simple to prepare and robust for routine analysis and it was used for the determination of creatinine in urine after simple thin‐layer separation procedure to avoid interference from creatine.

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Analytical methods for quantifying creatinine within biological media

Cited by 78 publications

References 103 publications

A New Method for the Determination of Creatinine in Urine Samples Based on Disposable Pipette Extraction

A New Method for the Determination of Creatinine in Urine Samples Based on Disposable Pipette Extraction

Trend in creatinine determining methods: Conventional methods to molecular‐based methods

Determination of Creatinine in Urine by Voltammetry and Glassy Carbon Electrode Modified with Functionalized Multi‐walled Carbon Nanotubes and Copper

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