Analytical detection techniques for droplet microfluidics—A review

Zhu, Ying; Fang, Qun

doi:10.1016/j.aca.2013.04.064

Cited by 314 publications

(217 citation statements)

References 118 publications

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“…Droplet microfluidic systems have already been practiced in analytical detection by applying various techniques for high quality content analysis in droplets. These analytical detection methods involve image-based analysis, electrochemistry, laser-based molecular spectroscopy, mass spectrometry, capillary electrophoresis, nuclear magnetic oscillation spectroscopy, chemiluminescence detection [5]. A couple of most used droplet detection techniques can include surface-enhanced Raman scattering (SERS), fluorescence, capacitive, electrochemistry, and mass spectrometry.…”

Section: Introductionmentioning

confidence: 99%

A Pump Based Microfluidic Image Processing System for Droplet Detection and Counting

Mehmood

Haider²,

Yin

2018

IOP Conf. Ser.: Mater. Sci. Eng.

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Section: Introductionmentioning

confidence: 99%

A Pump Based Microfluidic Image Processing System for Droplet Detection and Counting

Mehmood

Haider²,

Yin

2018

IOP Conf. Ser.: Mater. Sci. Eng.

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“…In such devices, droplets are used in analytic detection, reagent mixing, drug delivery and cell encapsulation process to name a few (Teh et al 2008;Huebner et al 2008;Di Carlo et al 2007;Baroud et al 2010;Zhu & Fang 2013). Surfactants (or surface-active agents) are common in these droplet-based devices.…”

Section: Introductionmentioning

confidence: 99%

Effect of temperature gradient on the cross-stream migration of a surfactant-laden droplet in Poiseuille flow

2017

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The motion of a viscous droplet in unbounded Poiseuille flow under the combined influence of bulk-insoluble surfactant and linearly varying temperature field aligned in the direction of imposed flow is studied analytically. Neglecting fluid inertia, thermal convection and shape deformation, asymptotic analysis is performed to obtain the velocity of a force-free surfactantladen droplet. The droplet speed and direction of motion are strongly influenced by the interfacial transport of surfactant which is governed by surface Péclet number. The present study is focused on the following two limiting situations of surfactant transport: (i) surface diffusion dominated surfactant transport considering small surface Péclet number, and (ii) surface convection governed surfactant transport considering high surface Péclet number. Thermocapillary-induced Marangoni stress, strength of which relative to viscous stress is represented by thermal Marangoni number, has strong influence on the distribution of surfactant on the droplet surface. Temperature field not only affects the axial velocity of the droplet but also has significant effect on the cross-stream velocity of the droplet in spite of the fact that the temperature gradient is aligned with the Poiseuille flow direction. When the imposed temperature increases in the direction of Poiseuille flow, the droplet migrates towards the flow centerline. The magnitude of both axial and crossstream velocity components increases with the thermal Marangoni number. However, when the imposed temperature decreases in the direction of Poiseuille flow, the magnitude of both axial and cross-stream velocity components may increase or decrease with the thermal Marangoni number. Most interestingly, the droplet moves either towards the flow centerline or away from it. Present study shows a critical value of the thermal Marangoni number beyond which the droplet moves away from the flow centerline which is in sharp contrast to the motion of a surfactant-laden droplet in isothermal flow for which droplet always moves towards the flow centerline.

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“…Quantitative and qualitative analysis of the droplet content is crucial in the development and application of droplet microfluidics. Various analytical detection techniques have been used to analyze droplet content, including imagingbased methods, laser-based molecular spectroscopy, electrochemical detection, capillary electrophoresis, mass spectrometry, NMR, absorption and chemiluminescence detection [66].…”

Section: Droplet-based Chemical Synthesismentioning

confidence: 99%

Droplet microfluidics: A tool for biology, chemistry and nanotechnology

Mashaghi

Abbaspourrad

Weitz

et al. 2016

TrAC Trends in Analytical Chemistry

311

188

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The ability to perform laboratory operations on small scales using miniaturized devices provides numerous benefits, including reduced quantities of reagents and waste as well as increased portability and controllability of assays. These operations can involve reaction components in the solution phase and as a result, their miniaturization can be accomplished through microfluidic approaches. One such approach, droplet microfluidics, provides a high-throughput platform for a wide range of assays and approaches in chemistry, biology and nanotechnology. We highlight recent advances in the application of droplet microfluidics in chipbased technologies, such as single-cell analysis tools, small-scale cell cultures, in-droplet chemical synthesis, high-throughput drug screening, and nanodevice fabrication.

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Analytical detection techniques for droplet microfluidics—A review

Cited by 314 publications

References 118 publications

A Pump Based Microfluidic Image Processing System for Droplet Detection and Counting

A Pump Based Microfluidic Image Processing System for Droplet Detection and Counting

Effect of temperature gradient on the cross-stream migration of a surfactant-laden droplet in Poiseuille flow

Droplet microfluidics: A tool for biology, chemistry and nanotechnology

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