Analytical and Preparative Chiral Separation of β-Carboline Derivatives, LDL Oxidation Inhibitors, Using HPLC and CE Methodologies: Determination of Enantiomeric Purity

Lipka, Emmanuelle; Yous, Saı̈d; Furman, Christophe; Carato, Pascal; Deghaye, Carole; Bonte, Jean‐Paul; Vaccher, Claude

doi:10.1007/s10337-012-2194-8

Cited by 12 publications

(11 citation statements)

References 24 publications

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“…In another study, Lipka et al. used HS‐γ‐CD for the separation of 16 new synthesized chiral β‐carboline derivatives. These are compounds that are structurally related to melatonin, and they are proposed as possible antioxidants inhibiting the low‐density lipoprotein.…”

Section: Chiral Selectorsmentioning

confidence: 99%

Chiral selectors in CE: Recent developments and applications (2012‐mid 2014)

Stavrou

Mavroudi

Kapnissi‐Christodoulou

2014

Electrophoresis

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There is a large number of chiral selectors (CSs) that have, over the years, been synthesized and used in electrophoretic enantioseparations. This report highlights the most important CSs applied in CE during the period 2012 to mid-2014. It is mainly focused on method developments and validations, along with pharmaceutical and biomedical applications. Even though numerous publications have, through the years, reported the utilization of CSs in enantioseparations, only the ones applied in electrophoretic techniques the last approximately three years are demonstrated in this review article. In particular, cyclodextrins, cyclofructants, linear and branched oligo- and polysaccharides, antibiotics, and polymeric surfactants are presented, and their advantages, their chiral recognition mechanisms, and their performance are discussed.

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Section: Chiral Selectorsmentioning

confidence: 99%

Chiral selectors in CE: Recent developments and applications (2012‐mid 2014)

Stavrou

Mavroudi

Kapnissi‐Christodoulou

2014

Electrophoresis

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“…The technique with a major limitation on the volume injected hydrodynamically is NSS, because only a small amount of sample can be injected into the capillary without loss of resolution (typically <10% capillary length). Lipka et al evaluated the possibility of using NSS as preconcentration technique to study β‐carboline derivatives. In this case, NSS was performed by an injection of 50 mbar during 20 s for the chiral analysis of 16 β‐carboline derivatives.…”

Section: Approaches To Improve the Detection Sensitivitymentioning

confidence: 99%

New approaches in sensitive chiral CE

et al. 2013

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CE has shown to have a big potential for chiral separations, with advantages such as high efficiency, high resolution, and low sample and reagents consumption. Nevertheless, when UV detection is employed, CE has some drawbacks, especially the low sensitivity obtained due to the short optical path length. Notwithstanding, sensitivity improvements can be achieved when different approaches are employed, such as sample treatment strategies (off-line or on-line), in-capillary sample preconcentration techniques, and/or alternative detection systems to UV-Vis (such as fluorescence, conductimetry, electrochemiluminiscence, MS, etc.). This article reviews the most recent methodological and instrumental advances reported from June 2011 to May 2013 for enhancing the sensitivity in chiral analysis by CE. The sensitivity achieved for the enantioseparated analytes and the applications carried out using the developed methodologies are also summarized.

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“…Other reports focused on the enantioseparation of various classes of compounds such as β‐carboline derivatives , helquats , iodiconazol and other triadimenol analogs , antimalarics , and cathinone derivatives with different CDs. The main goal was the screening of different CD derivatives for the chiral separations in these studies.…”

Section: Recent Applications Of Ce Enantioseparationsmentioning

confidence: 99%

Recent advances in electrodriven enantioseparations

Jáč

Scriba

2012

J of Separation Science

109

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Capillary electromigration techniques have developed into significant analytical separation tools especially for enantioseparations. While CE can be considered a mature technique as documented by its wide applications, CEC is still in a developmental state despite many research efforts. The success of stereospecific CE separation methods is due to the high specificity and flexibility of the technique as well as the availability of many types of chiral selectors. Thus, numerous methods have been developed for the analysis of chiral compounds in chemical, biochemical, pharmaceutical, environmental, and forensic sciences. However, most reported applications deal with pharmaceuticals. The search for new chiral selectors also continued despite the fact that most applications were performed using cyclodextrins. Furthermore, CE has been combined with spectroscopic and molecular modeling studies in attempts to understand the interactions between chiral selectors and analytes. The present review focuses on recent examples of mechanistic aspects of capillary enantioseparations with regard to mathematical modeling of enantioseparations, investigations of the analyte-complex structures as well as new chiral selectors and applications of chiral analyses by CE and CEC. It covers the literature published between January 2011 and August 2012.

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Analytical and Preparative Chiral Separation of β-Carboline Derivatives, LDL Oxidation Inhibitors, Using HPLC and CE Methodologies: Determination of Enantiomeric Purity

Cited by 12 publications

References 24 publications

Chiral selectors in CE: Recent developments and applications (2012‐mid 2014)

Chiral selectors in CE: Recent developments and applications (2012‐mid 2014)

New approaches in sensitive chiral CE

Recent advances in electrodriven enantioseparations

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